The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation Therapy

Yu, Jeong Il; Park, Hee Chul; Lim, Do Hoon; Choi, Young Bae; Jung, Sang Hoon; Paik, Seung Woon; Kim, Seong Hyun; Jeong, Woo Kyoung; Kim, Young Kon

doi:10.1016/j.ijrobp.2014.03.020

Cited by 24 publications

(22 citation statements)

References 26 publications

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“…Inclusion of DWI in the imaging protocol has been shown to significantly enhance the diagnostic accuracy (91%-97% vs 72%) for detection of viable tumors after radiation treatment with improved sensitivity, specificity, and negative predictive value as compared to routine MR sequences (90%-97%, 91%-97% and 91%-97% vs 41%-55%, 86%-97% and 67%-70%, respectively)[ 75 ]. ADC values have also been shown to correlate with local progression-free survival[ 76 ]. Another group demonstrated that ADC values correlate with local progression-free survival and proposed that ADC and RECIST criteria could be substituted for mRECIST in post-radiation evaluation of patients not amenable to receiving contrast agents[ 76 ].…”

Section: Clinical Applications In Livermentioning

confidence: 99%

“…ADC values have also been shown to correlate with local progression-free survival[ 76 ]. Another group demonstrated that ADC values correlate with local progression-free survival and proposed that ADC and RECIST criteria could be substituted for mRECIST in post-radiation evaluation of patients not amenable to receiving contrast agents[ 76 ].…”

Section: Clinical Applications In Livermentioning

confidence: 99%

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Diffusion weighted magnetic resonance imaging of liver: Principles, clinical applications and recent updates

Shenoy-Bhangle

Baliyan

Kordbacheh

et al. 2017

WJH

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Diffusion-weighted imaging (DWI), a functional imaging technique exploiting the Brownian motion of water molecules, is increasingly shown to have value in various oncological and non-oncological applications. Factors such as the ease of acquisition and ability to obtain functional information in the absence of intravenous contrast, especially in patients with abnormal renal function, have contributed to the growing interest in exploring clinical applications of DWI. In the liver, DWI demonstrates a gamut of clinical applications ranging from detecting focal liver lesions to monitoring response in patients undergoing serial follow-up after loco-regional and systemic therapies. DWI is also being applied in the evaluation of diffuse liver diseases such as non-alcoholic fatty liver disease, hepatic fibrosis and cirrhosis. In this review, we intend to review the basic principles, technique, current clinical applications and future trends of DW-MRI in the liver.

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Section: Clinical Applications In Livermentioning

confidence: 99%

Section: Clinical Applications In Livermentioning

confidence: 99%

Diffusion weighted magnetic resonance imaging of liver: Principles, clinical applications and recent updates

Shenoy-Bhangle

Baliyan

Kordbacheh

et al. 2017

WJH

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“…A systemic review demonstrated that as apparent diffusion coefficient (ADC) of pretherapy and posttherapy in uterine cervical cancer was compared, complete responders had higher increase than partial responders or nonresponders [12]. Moreover, ADC changes between pretherapy and posttherapy were related to clinical outcomes in hepatocellular carcinoma [13] and head and neck cancer [14]. However, few studies have demonstrated the utility of DWI for the prediction of clinical outcomes regarding tumor recurrence after CCRT in uterine cervical cancer [15].…”

mentioning

confidence: 99%

Can diffusion-weighted magnetic resonance imaging predict tumor recurrence of uterine cervical cancer after concurrent chemoradiotherapy?

et al. 2016

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“…Diffusion MRI sequences have been shown to predict response to RT [86,87] earlier than gross tumor size changes or metabolic changes based on FDG PET-CT [88]. Both the baseline apparent diffusion coefficient (ADC) and changes in ADC, specifically increase in ADC after RT, correlate with tumor control and patient outcome after radiotherapy [89][90][91][92][93][94]. The UCLA group recently published the results of a pilot study utilizing a spin echo-based diffusion sequence on the tri- 60 Co system to track changes in diffusion over the course of RT for six patients [95].…”

Section: Adaptive Radiotherapymentioning

confidence: 99%

MRI-guided radiotherapy: Opening our eyes to the future

Kishan¹,

Lee²

2016

Integr Cancer Sci Therap

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When discussing local treatment modalities, physicians often quip that there can be no blind surgeons, suggesting that an inherent advantage to surgery is the ability to precisely visualize the target. Advances in radiation therapy (RT) technology over the years have significantly improved the radiation oncologists' abilities to precisely sculpt high-dose radiation to a variety of targets, simultaneously improving local control and toxicity profiles. However, even the most sophisticated methods of CT-based image-guided radiotherapy (IGRT) are hampered by limitations that can compromise target localization and motion management. Additionally, realtime adaptive radiotherapy (ART) programs, wherein radiation plans can be molded to fit the often malleable anatomy of tumors and organs-at-risk, have not yet been developed. For these reasons, MRI-guided RT is considered the next frontier of radiation oncology. However, the development of integrated MRI/RT-delivery platforms is complicated by several technical challenges that have precluded development of MRI-guided linear accelerators. By virtue of employing a low-field (0.35 T) MRI and three 60 Co sources, a newly available tri-60 Co teletherapy system (MRIdian System™, ViewRay™, Cleveland, OH, USA) has tackled these technical concerns and has thus become the first MRI-guided RT platform with FDA approval for medical use. In this Review, we describe the abilities of this device to accomplish the goals of MRI-guided RT-improved target localization, sophisticated motion management, and on-line ART-by exploring published feasibility, proof-of-principle, and proof-of-practice studies.

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The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation Therapy

Cited by 24 publications

References 26 publications

Diffusion weighted magnetic resonance imaging of liver: Principles, clinical applications and recent updates

Diffusion weighted magnetic resonance imaging of liver: Principles, clinical applications and recent updates

Can diffusion-weighted magnetic resonance imaging predict tumor recurrence of uterine cervical cancer after concurrent chemoradiotherapy?

MRI-guided radiotherapy: Opening our eyes to the future

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