The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review

Grazzini, Irene; Venezia, Duccio; Cuneo, Gian Luca

doi:10.1177/1971400920975153

Cited by 14 publications

(20 citation statements)

References 100 publications

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“…In addition, the volume of the white matter of the brain was negatively correlated with the total score of the iNPHGS, suggesting that the more obvious the deformation of the white matter caused by pressure, the more severe the clinical symptoms. A study on iNPH using diffusion tensor imaging (DTI) found changes in the microstructure of the white matter of the brain, damage to the white matter axons around the ventricle, and gliosis ( 18 ). A DTI study also found corticospinal tract injury in patients with iNPH ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis

Yang

Zhou

et al. 2022

Front. Neurol.

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The cause of idiopathic normal pressure hydrocephalus's (iNPH) clinical symptoms remains unclear. The cerebral cortex is the center of the brain and provides a structural basis for complex perception and motor function. This study aimed to explore the relationship between changes in cerebral cortex volume and clinical symptoms in patients with iNPH. This study included 21 iNPH patients and 20 normal aging (NA) controls. Voxel-based morphometry statistical results showed that, compared with NA, the gray matter volumes of patients with iNPH in the bilateral temporal lobe, bilateral hippocampus, bilateral thalamus, bilateral insula, left amygdala, right lenticular nucleus, right putamen, and cerebellum decreased, while the volumes of gray matter in the bilateral paracentral lobules, precuneus, bilateral supplementary motor area, medial side of the left cerebral hemisphere, and median cingulate and paracingulate gyri increased. Correlation analysis among the volumes of white matter and gray matter in the cerebrum and cerebellum and the iNPH grading scale (iNPHGS) revealed that the volume of white matter was negatively correlated with the iNPHGS (P < 0.05), while the gray matter volumes of cerebellar area 6 and area 8 were negatively correlated with the clinical symptoms of iNPH (P < 0.05). The volume of gray matter in the cerebellar vermis was negatively correlated with gait, and the gray matter volume of cerebellar area 6 was negatively correlated with cognition. Our findings suggest that the cerebellum also plays an important role in the pathogenesis of iNPH, potentially highlighting new research avenues for iNPH.

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Section: Discussionmentioning

confidence: 99%

Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis

Yang

Zhou

et al. 2022

Front. Neurol.

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“…Cranial brain injury is a common neurosurgery traumatic disease, of which 70%~90% are mild to the brain injury, most of which are reversible forgetting, transient loss of consciousness, and other symptoms, which seriously affect the life, study, and work of patients [ 1 ]. However, due to the low positive rate of mild craniocerebral injury in skull, CT and conventional magnetic resonance imaging (MRI) examination and the lack of attention to neurosurgery, it is easy to cause the development of the disease and even lifelong disability.…”

Section: Introductionmentioning

confidence: 99%

To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury

Xin

Qin

Zhu

2022

BioMed Research International

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In order to assess the value of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in microscopic brain scans. Diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRI) changes over time in patients with traumatic brain injury (TBI) show a relationship between recovery from coma and overall Glasgow prognostic parameters. The value of DTI combined with MRI in evaluating TBI has been investigated. 10 patients with TBI received 10 evaluations of magnetic resonance imaging, DTI and MRI scans. Thalamic plate nucleus, reticular nucleus, and retinal developmental activity were measured in normal controls and TBI coma (2-3 weeks) and mild (>4 weeks) patients. Anisotropy, mean diffusion coefficient, axial diffusion coefficient, and radial diffusion coefficient were measured using MRI together with acetylaspartic acid, choline, creatinine, and lactic acid. Independent control t-tests were conducted between controls and TBI patients, and 1-test paired between moderate and severe injuries, and regression and correlation were evaluated. Evaluated for all measures and treatments. DTI and MRI scores in TBI patients differed from normal controls. DTI and MRI can predict the prognosis of TBI patients better. The limitations of the thalamus-retinal activation system are gradually restored. axial diffusion coefficient and radial diffusion coefficient can be used to evaluate the reliability of comatose patients with TBI. DTI and MRI scans of the patient’s brain can predict recovery and guide treatment in TBI coma patients.

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“…Increased FA signal is reported as a prominent characteristic in NPH compared to other neurodegenerative diseases like AD or Parkinson's disease where FA is decreased. However, recent research reports decreased FA of the corticospinal tracts in NPH [60].…”

Section: Imagingmentioning

confidence: 89%

Normal Pressure Hydrocephalus: Revisiting the Hydrodynamics of the Brain

Hakim¹,

Jaramillo-Velásquez²,

Gonzalez³

et al. 2022

Cerebrospinal Fluid

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Normal pressure hydrocephalus syndrome is the most common form of hydrocephalus in the elderly and produces a dementia which can be reversible surgically. It is characterized by ventriculomegaly and the classic triad of symmetric gait disturbance, cognitive decline and urinary incontinence, also known as Hakim’s triad. To date, the exact etiology of the disease has not been elucidated and the only effective treatment is a cerebrospinal fluid shunting procedure which can be a ventriculoatrial, ventriculoperitoneal or lumboperitoneal shunt. The most important problem is the high rate of underdiagnosis or misdiagnosis due to similarities in symptoms with other neurodegenerative disorders, and in some cases, coexistence. Hence, increasing awareness amongst the community and medical professionals in order to increase clinical suspicion, timely diagnosis and treatment are paramount. The best way to achieve this is by having a structured protocol with patient-centered tests that evaluates the entire myriad of alterations a clinician might encounter whenever treating patients with this disorder. Recent advances in imaging technology as well as cerebrospinal fluid biomarkers have given interesting insight into the pathophysiology of the disease and will certainly contribute greatly in diagnostic advancements. We finally present an institutional protocol which has been accredited by international peers with promising results in diagnostic and outcome rates.

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The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review

Cited by 14 publications

References 100 publications

Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis

Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis

To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury

Normal Pressure Hydrocephalus: Revisiting the Hydrodynamics of the Brain

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