The role of dietary selenium in bovine mammary gland health and immune function

Salman, Saad; Khol-Parisini, A.; Schafft, Helmut; Lahrssen‐Wiederholt, Monika; Hulan, H. W.; Dinse, Daniela; Zentek, Jürgen

doi:10.1017/s1466252308001588

Cited by 54 publications

(41 citation statements)

References 87 publications

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“…The importance of mastitis is emphasised by the fact that it produces huge losses in cattle industry (Salman, 2009;Maćešić et al, 2016). Also, its importance is significant from the aspect of public health, milk processing and animal welfare (Bačić, 2009).…”

Section: Mastitismentioning

confidence: 99%

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Turk

2017

Mljekarstvo

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Mastitis is one of the most frequent diseases of dairy cows throughout the world, therefore it causes the greatest economic losses in dairy cattle industry. These losses are reflected through: reduced milk production, increased costs of medication and the other animal health services, reduced fertility, early culling of animals and the value of discarded milk. Mastitis is also important from the aspects of public health, milk processing and animal welfare. In the pathogenesis of mastitis the key role plays the innate immune response which is the first line of defence against the pathogen invasion of the udder. The innate immune response generates an inflammatory reaction which is the elementary response of an organism to the tissue trauma induced by any physical, chemical or biological causative agent, but primarily it is the protective mechanism of a vital significance which includes increased phagocytic activity, secretion of antimicrobial substances, fibrosis as well as the alterations in tissue structure of affected organ or body cavity. The release of a number of inflammatory mediators as well as reactive oxygen species (ROS) is an important part of inflammatory response. In dairy cows, the metabolic challenge that occurred during the transition from dry period to early lactation may additionally increase the release of ROS which may contribute to development of oxidative stress and inflammatory response. Oxidative stress is defined as a shift in the balance from cellular oxidation-reduction reactions towards oxidation, i.e. to the state of excessive release of oxidants when their removal by antioxidants is impaired and even insufficient. During peripartum period antioxidantive status of dairy cows is seriously impaired and consequently both the oxidative stress and inflammatory response may present the predisposing factors to their higher susceptibility to intramammary infections (IMI) and mastitis. This association between oxidative stress and inflammation during IMI and mastitis indicates their role in the pathogenesis of mastitis. Thus, a better understanding of such a synergism could contribute to development of new approaches to prevention and therapy of IMI and mastitis.

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Section: Mastitismentioning

confidence: 99%

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Turk

2017

Mljekarstvo

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“…The literature shows that the increase in the metabolic processes associated with the deficiency of substances with antioxidant activity are able to increase the oxidative stress in the body (3), impairing normal physiological functions of the mother and contributing to the appearance of diseases in children (4,5).…”

Section: Introductionmentioning

confidence: 99%

Effect of grape juice consumption on antioxidant activity and interleukin-6 concentration in lactating rats

Faria

Rosse

Dias³

et al. 2016

Nutr Hosp

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ResumenIntroducción: este estudio evaluó el efecto del consumo de zumo de uva sobre la capacidad antioxidante y el nivel de interleucina-6 en sangre de ratas lactantes. Material y método: dieciocho ratas Wistar lactantes adultas se dividieron en dos grupos: grupo control (CG) y grupo de zumo de uva (GJU). La actividad antioxidante se determinó mediante el método de secuestro de radicales libres (DPPH) y la Capacidad de Absorción Radical de Oxígeno (ORAC) por 2,2-difenil-1-picrilhidrazil (DPPH), y la interleucina-6 se determinó mediante Inmunosorbent Enzyme-linked Método de ensayo (ELISA). Los datos se presentaron como media y desviación estándar. Resultados: la capacidad antioxidante fue mayor (p < 0,05) en el GJU (25,00 ± 3,08 μmol ecuación Trolox/g) que en el CG (10,00 ± 3,11 μmol ecuación Trolox/g), según el método ORAC. El nivel de interleucina-6 (pg/ml) fue menor en el grupo de zumo de uva que en CG. Conclusión: el consumo de zumo de uva durante la lactancia mejora la capacidad antioxidante de las ratas lactantes y parece ser capaz de disminuir la actividad infl amatoria. AbstractObjective: This study evaluated the effect of grape juice consumption on the antioxidant capacity and the interleukin-6 blood level of lactating rats. Material and method: Eighteen Wistar rats, lactating females adult, were divided into two groups: control group (CG) and grape juice group (GJG). The antioxidant activity was determined by the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH)-kidnapping of free radicals (DPPH) and oxygen radical absorbance capacity (ORAC), and the interleukin-6 was determined by Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were presented as mean and standard deviation. Results: The antioxidant capacity was higher (p < 0.05) in the GJG (25.00 ± 3.08 µmol eq. Trolox/g) than in the CG (10.00 ± 3.11 µmol eq. Trolox/g), by the ORAC method. The interleukin-6 (pg/ml) level was lower in the grape juice group than in CG. Conclusion: The consumption of grape juice during lactation improves the antioxidant capacity in lactating rats and seems capable to decrease the infl ammatory activity.

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“…In the last few years, in an attempt to reduce the impact of mastitis and decrease the use of antimicrobials on dairy farms, there have been numerous efforts to try to exploit the immune capacity of the bovine mammary gland to stimulate the animal's natural defense mechanisms (Salman et al 2009). In addition, many studies point to a reduction in the incidence of mastitis with selenium (Se) supplementation, an idea reinforced by the negative correlation between somatic cell count (SCC) and the Se status of the animals (Hogan et al 1993, Paschoal et al 2003, Kruze et al 2007, Sánchez et al 2007, Salman et al 2009, Cortinas et al 2010.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, many studies point to a reduction in the incidence of mastitis with selenium (Se) supplementation, an idea reinforced by the negative correlation between somatic cell count (SCC) and the Se status of the animals (Hogan et al 1993, Paschoal et al 2003, Kruze et al 2007, Sánchez et al 2007, Salman et al 2009, Cortinas et al 2010. Most of the studies that investigated the effect of Se on immune function only compared animals with a low Se status to those with an adequate Se status.…”

Section: Introductionmentioning

confidence: 99%

“…Only a few studies have tried to investigate the mechanisms by which Se acts. There are still many gaps in our understanding of the interactions of Se with the immune response of the bovine mammary gland (Salman et al 2009). Additionally, some recent reports have demonstrated that levels of Se higher than those regarded as adequate can lead to an increase of the natural defense mechanisms of the bovine mammary gland (Salman et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Efeito da suplementação in vitro de selênio sobre neutrόfilos do leite e sanguíneos em vacas leiteras

Souza¹,

Blagitz²,

Latorre³

et al. 2012

Pesq. Vet. Bras.

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The study was designed to assess the effects of in vitro selenium addition on intracellular hydrogen peroxide production by neutrophils from the milk and blood of dairy cows. Blood from 10 dairy cows and 20 milk samples from ϐive dairy cows were incubated with 0 mg (control) or 10μM of sodium selenite. Then, milk and blood neutrophils were submitted for evaluation of intracellular hydrogen peroxide production by ϐlow cytometry using 2',7'-dichloroϐluorescein diacetate as a probe. The selenium status of the animals was evaluated by determination of the blood glutathione peroxidase activity. The results of the present work showed that in vitro selenium supplementation leads to an enhancement in intracellular hydrogen peroxide production, which indicates an improvement in the bactericidal effects of blood and milk neutrophils even in cows with a selenium-adequate status. Thus, the present study showed that in vitro Se supplementation leads to an enhancement in intracellular hydrogen peroxide production, indicating an improvement in the bactericidal effects of blood and milk neutrophils in cows with Se-adequate status. A determinação da produção intracelular de peróxido de hidrogênio se deu por citometria de ϐluxo através da utilização do 2´,7´ diclorodihidroϐluoresceína diacetato como sonda. A mensuração do conteúdo de selênio foi avaliada pela atividade da glutationa peroxidase eritrocitária. Os leucócitos polimorfonucleares tanto sanguíneos quanto do leite apresentaram signiϐicativo aumento na produção intracelular de H 2 O 2 com a suplementação in vitro de selênio. Desta forma, o presente estudo apontou para aumento da produção intracelular de H 2 O 2 , indicando aumento da capacidade microbicida dos leucócitos polimorfonucleares sanguíneos e lácteos mesmo em animais com níveis adequados de selênio.

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The role of dietary selenium in bovine mammary gland health and immune function

Cited by 54 publications

References 87 publications

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Effect of grape juice consumption on antioxidant activity and interleukin-6 concentration in lactating rats

Efeito da suplementação in vitro de selênio sobre neutrόfilos do leite e sanguíneos em vacas leiteras

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