The role of dietary protein in hepatic lipogenesis in the young rat

Herzberg, Gene R.; Rogerson, Minda

doi:10.1079/bjn19810131

Cited by 19 publications

(9 citation statements)

References 34 publications

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“…In the present study, the lowprotein diet resulted in decreased activity of G6PDH and increased activity of ME. These results are consistent with those reported by Herzberg and Rogerson (37). They suggest that the low-protein group primarily uses the ME-derived NADPH required for fatty acid synthesis.…”

Section: Discussionsupporting

confidence: 83%

“…It is interesting to note that Marten et al reported that the DNAbinding activity of hepatocyte nuclear factor-4 (HNF-4), which is known to control MTP mRNA expression (34,35), decreases in rats fed a protein-restricted diet (36). Recently microRNA-30c (miR-30c) was also reported as a regulator of MTP mRNA expression (37). In Soh's study with mice (38), miR-30c did not increase hepatic TG content despite a suppression of hepatic MTP mRNA expression at the same levels as in this study (approximately 50% decrease).…”

Section: Discussionmentioning

confidence: 99%

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Dietary Egg Yolk Supplementation Improves Low-Protein-Diet-Induced Fatty Liver in Rats

Erami

Tanaka

Kawamura

et al. 2016

J Nutr Sci Vitaminol

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Summary Egg yolk is an important source of nutrients and contains different bioactive substances. In the present study, we studied the benefits of egg yolk in preventing low-protein-diet-induced fatty liver in rats. Rats were fed the following diets, which were based on the AIN-76 formula, for 2 wk: an adequate-protein diet containing 20% casein (C), a lowprotein diet containing 5% casein (LP-C), a low-protein diet supplemented with 12.5% egg yolk (LP-EY), and a low-protein diet supplemented with 4.1% egg yolk oil (LP-EYO). The lowprotein diets were adjusted to contain 4.13% protein and 4.7% lipids. The LP-C diet resulted in a greater increase in the liver trigriceride (TG) and the vacuolation and a greater decrease in the serum TG and free fatty acid (FFA) than did the C diet. These deviations in the serum and liver TG, serum FFA levels and the liver histopathology were corrected in rats fed the LP-EY diet but not in those fed the LP-EYO diet. Compared to rats fed the LP-C diet, although the activities of lipogenesis-related enzymes (fatty acid synthase, glucose-6-phosphate dehydrogenase, and malic enzyme) decreased in rats fed both of the LP-EY and LP-EYO diets, the level of the microsomal TG transfer protein (MTP) increased only in rats fed the LP-EY diet. Collectively, these results suggest that dietary egg yolk supplementation decreases the LP diet-induced accumulation of TG in the liver by increasing transport of TG in the liver, and egg yolk oil alone is not sufficient enough to bring about these benefits.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Dietary Egg Yolk Supplementation Improves Low-Protein-Diet-Induced Fatty Liver in Rats

Erami

Tanaka

Kawamura

et al. 2016

J Nutr Sci Vitaminol

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“…In contrast, the content of hepatic traps-fatty acids was influenced by the type, but not the level of dietary fat (Table 3). The significantly greater retention of trans octadecenoates in rats fed safflower oil than in those fed olive oil is in line with the observation that a dietary fat-dependent increase in fatty acid oxidation activity is more prominent in rats fed dietary fat rich in oleic acid than in those fed fat rich in linoleic acid (24).…”

Section: Discussionsupporting

confidence: 71%

Dietary manipulation of the disappearance of trans-octadecenoates in rat tissues.

Cho

Ishii

Sugano

1986

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of dietary manipulations on the fate of trans octadecenoates deposited in the tissues of rats were examined . Male rats were fed on a 15% fat diet containing trans-octadecenoic acids (46 .6% of total fatty acids) for 35 days followed by various diets free of trans-fatty acids. After removal of traps-fatty acids from the diet, there were phased disappearances of trans-octadecenoates from the circulation; a rapid and broad reduction in one day and a slow and gradual reduction thereafter . The rate of the initial reduction in serum trans-octadecenoates was highest on a high fat (20%) diet in relation to low fat (1 or 5%) diets . However, the disappearance rate at the later stage was apparently the same among the various groups and traps-fatty acid contents in the serum declined to about 10% of the initial value in 2 weeks and thereafter . After 35 days, the concentration of traps-octadecenoates remaining in the adipose tissue was markedly lower in rats fed on a high protein (40%) diet . The effects of dietary fat type and cholesterol on the fate of serum trans-octadecenoates were virtually the same, but livers from rats fed on the cholesterol-free safflower oil diet contained more trans-fatty acids than those from rats fed on the corresponding olive oil diet. Thus, the amounts of traps-fatty acids stored in the tissues cannot be merely predicted from serum levels . It seems that both dietary fat and protein affect the metabolic rate of trans octadecenoates in rats.

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“…The lipogenic rate per g liver as well as the specific activities of the enzymes measured, except ME and GK, also increased with the increased growth rate. This was observed in the present study and in our previous work (Herzberg & Rogerson, 1981). Thus as the growth rate increases, there is an increase in the specific activities of the enzymes involved in hepatic lipogenesis.…”

Section: G R Herzberg a N D Minda Rogersonsupporting

confidence: 77%

Hepatic lipogenesis in young rats given proteins of different quality

Herzberg

Rogerson

1984

Br J Nutr

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1. The effect of feeding casein, lactalbumin, soya-bean protein, gluten or gelatin on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1. 1. 1.49; G6PD), malic enzyme (EC 1. 1. 1.40; ME) ATP-citrate lyase (EC 4. 1. 3. 8; CL), acetyl CoA carboxylase (EC 6.4.1.2; ACCx) and glucokinase (EC 2. 7. 1. 2; GK) was examined in young growing rats.2. The total activities of ACCx, FAS, CL, GK, G6PD, GK, ME and fatty acid synthesis in vivo were positively correlated with protein quality.3. The specific activities of ACCx, FAS, CL, G6PD and fatty acid synthesis in vivo were positively correlated with protein quality.4. The specific activities of GK and ME were unrelated to protein quality.5. The results demonstrate a dissociation between ME and hepatic lipogenesis and suggest a role for the NADPH generated by ME which is not related to the needs of fatty acid synthesis.

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The role of dietary protein in hepatic lipogenesis in the young rat

Cited by 19 publications

References 34 publications

Dietary Egg Yolk Supplementation Improves Low-Protein-Diet-Induced Fatty Liver in Rats

Dietary Egg Yolk Supplementation Improves Low-Protein-Diet-Induced Fatty Liver in Rats

Dietary manipulation of the disappearance of trans-octadecenoates in rat tissues.

Hepatic lipogenesis in young rats given proteins of different quality

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