2012
DOI: 10.1155/2012/541971
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The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety

Abstract: Although it has been long believed that new neurons were only generated during development, there is now growing evidence indicating that at least two regions in the brain are capable of continuously generating functional neurons: the subventricular zone and the dentate gyrus of the hippocampus. Adult hippocampal neurogenesis (AHN) is a widely observed phenomenon verified in different adult mammalian species including humans. Factors such as environmental enrichment, voluntary exercise, and diet have been link… Show more

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Cited by 122 publications
(96 citation statements)
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References 123 publications
(161 reference statements)
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“…NSC proliferation in the DG region was increased by curcumin treatment in BPA-treated rats. This temporal profile of the neuroprotective actions of curcumin on NSC proliferation is consistent with the findings of other classes of polyphenolic neurogenic compounds [69,70]. A similar finding suggests that polyphenol-and polyunsaturated fatty acid-enriched diet also increases the number of newborn cells in the adult mouse hippocampus and SVZ [70].…”
Section: Discussionsupporting
confidence: 87%
“…NSC proliferation in the DG region was increased by curcumin treatment in BPA-treated rats. This temporal profile of the neuroprotective actions of curcumin on NSC proliferation is consistent with the findings of other classes of polyphenolic neurogenic compounds [69,70]. A similar finding suggests that polyphenol-and polyunsaturated fatty acid-enriched diet also increases the number of newborn cells in the adult mouse hippocampus and SVZ [70].…”
Section: Discussionsupporting
confidence: 87%
“…Several studies reported that dietary phytochemicals affect adult hippocampal neurogenesis, suggesting a potential role in treating depression and anxiety disorders Dias et al, 2012). A diet enriched in polyphenols and polyunsaturated fatty acids induces neurogenesis in the hippocampus of adult mice (Valente et al, 2009).…”
Section: Psychologic Stressmentioning
confidence: 99%
“…Therefore, many questions regarding postischemic hippocampal neurogenesis remain open, among them the aspect of timing after ischemia. Neurogenesis in the hippocampus is regulated by numerous elements, including neuropathological conditions such as ischemic episodes and diet [11,30]. Given that dietary factors have been proved to change the time course after ischemic neurodegeneration [66,77], and the same factors have been shown to modulate neurogenesis in the hippocampus [59], it is possible that the effects of diet on postischemic neurodegeneration are mediated by modulation of hippocampal neurogenesis.…”
Section: The Importance Of Hippocampal Neurogenesis In Postischemic Bmentioning
confidence: 99%