The role of dietary factors in inflammatory bowel diseases: New perspectives

Zhou, Yi; Xu, Renying; Yan, Wei

doi:10.1111/1751-2980.12686

Cited by 11 publications

(5 citation statements)

References 99 publications

(159 reference statements)

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“…In addition, higher meat or meat products consumption were positively associated with the risk of CD for both Western and Eastern populations, but not with the risk of UC. Previous studies have proposed that SFAs are pro‐inflammatory dietary components, while MUFAs and PUFAs can act as anti‐inflammatories 69 . A balanced ratio of n‐3 to n‐6 PUFA is essential for maintaining homeostasis 67 .…”

Section: Discussionmentioning

confidence: 99%

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Zhao

Feng

Ben‐Horin

et al. 2021

Aliment Pharmacol Ther

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Summary Background While the incidence of inflammatory bowel disease (IBD) has stabilised in the West, it is still increasing in several newly industrialised countries. Aims To investigate whether the environmental and dietary risk factors for IBD differ between Eastern and Western populations Methods We systematically searched PubMed, Embase, and Web of Science for studies published from inception through June 30, 2020. Data were pooled using a random effects model. Results Overall, 255 studies were assessed. We identified 25 risk factors for IBD, seven of which were noted in both Eastern and Western populations: family history of Crohn's disease [CD] or ulcerative colitis [UC], former smoking (CD/UC), smoking (CD), appendicectomy (CD), tonsillectomy (CD), meat and meat products (CD), and vitamin D deficiency (UC). The remaining factors, including urban living, current smoking, antibiotics, oral contraceptives, caesarean section, isotretinoin, total energy, fat, cholesterol, fatty acids and their sub‐classifications, eggs, and soft drinks, were associated with an increased risk of IBD in Western or Eastern populations only. We identified 21 protective factors for IBD, among which eight were common in the East and West: farm animals (CD/UC), Helicobacter pylori infection (CD/UC), multiple births (CD), physical activity (CD), history of breastfeeding (CD), pets (UC), current smoking (UC), and coffee intake (UC). Ten factors conferred protection against IBD in Western populations only, whereas eight factors conferred protection against IBD in Eastern populations only. Conclusions Numerous environmental and dietary factors influenced the development of IBD in both Western and Eastern populations, whereas certain factors influenced IBD risk differently in these populations.

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Section: Discussionmentioning

confidence: 99%

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Zhao

Feng

Ben‐Horin

et al. 2021

Aliment Pharmacol Ther

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“…Overall physical activity was measured using a wrist-worn accelerometer device in a subsample of 91,000 individuals 16 . Finally, we analyzed vitamins and fatty acids levels as metabolites affected by the type of dietary intake 17,18 . Genetic instruments were identified for circulating levels of vitamin D 19 , vitamin B9 and B12 20 , polyunsaturated omega-3 and omega-6, monounsaturated (mainly omega-7 and omega-9) fatty acids, and total fatty acids 21 .…”

Section: Identification Of Genetic Determinants For Potential Risk Famentioning

confidence: 99%

Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study

Carreras‐Torres

Ibáñez‐Sanz

Obón-Santacana

et al. 2020

Sci Rep

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Several studies have examined environmental factors and inflammatory bowel diseases (IBD) using traditional approaches; however, provided results are still conflicting. Our aim was to determine whether lifestyle and nutrient exposures, related to IBD in observational meta-analyses, influence IBD risk using a Mendelian randomization (MR) approach. A two-sample MR approach was applied on summary-level genome-wide association results. Genetic variants strongly associated with measures of tobacco smoking, obesity and fat distribution, physical activity, and blood levels of vitamins and fatty acids were evaluated on genetic data from international IBD consortia including a total of 25,042 IBD cases (12,194 cases of Crohn’s disease (CD) and 12,366 cases of ulcerative colitis (UC)) and 34,915 controls. Our results indicated that, among lifestyle exposures, being a smoker was positively associated with CD (OR 1.13, P = 0.02), but it was not associated with UC risk (OR 0.99, P = 0.88). Body-mass index (BMI) and body fat percentage were positively associated with CD (OR 1.11, P = 0.02, per standard deviation (SD) of 4.6 kg/m2; and OR 1.50, P = 3 × 10–10, per SD of 6.6%; respectively); while for UC, BMI was inversely associated (OR 0.85, P = 5 × 10–5; per SD) and body fat percentage showed a OR of 1.11 (P = 0.11; per SD). Additionally, among nutrient exposures, omega-3 fatty acids levels were inversely associated with CD (OR 0.67, P = 2 × 10–6). Our MR results did not support a protective effect for being a smoker on UC risk; however, they are compatible with a risk effect for higher body fat proportion and a protective role for higher levels of omega-3 fatty acids on CD etiology.

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“…The diseases themselves could increase the concentration of hs-CRP and its drugs used in these diseases might also increase the concentration of blood glucose as well. However, the incidence of these diseases in general population is low in China [31][32][33][34][35] and the dosage of corticosteroid during the quiescent phage of the diseases is low. We thus assumed the possible impacts of the diseases and its related treatment is minimal in the current study.…”

Section: Discussionmentioning

confidence: 99%

The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

Jiang

Fan

et al. 2020

Nutr Metab (Lond)

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Background: We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults. Methods: Included were 6439 adults (4111 men and 2249 women; aged 46.6 ± 11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (≥126 mg/dl) or Hb A1c (≥6.5%) during subsequent 3 years (2016-2018). Results: Hs-CRP concentration during 2013-2015 was classified into 3 levels: low (< 1.0 mg/L), moderate (1.0-3.0 mg/ L), and high (≥3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectories as following: "low-stable" (low in 2013 and maintained at low concentration in 2014 and 2015), "moderate-fluctuated" (moderate in 2013, then increased to high concentration in 2014, and decreased to low concentration in 2015), "highdecreased" (high in 2013 but decreased to moderate concentration in 2014 and 2015), and "moderate-increased (moderate in 2013 and increased to high concentration in 2014 and 2015)". We identified 235 incident diabetes during subsequent 3 years. The adjusted HR for incident diabetes was 1.71 (95% CI: 1.02, 2.87) comparing the moderateincreased and the low-stable group, after adjusting for potential confounders. In the secondary analyses, two singlemeasured hs-CRP concentration (in 2013 or in 2015) and the average of hs-CRP were associated with high risk of diabetes (P-trend< 0.01 for all). Conclusions: The hs-CRP trajectory pattern was associated with altered incident diabetes in Chinese adults.

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The role of dietary factors in inflammatory bowel diseases: New perspectives

Cited by 11 publications

References 99 publications

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study

The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

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