The Role of Diet in Inflammatory Bowel Disease

Shivashankar, Raina

doi:10.1007/s11894-017-0563-z

Cited by 43 publications

(34 citation statements)

References 42 publications

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“…Over the last 2 years there has been a significant number of studies referring to adoption of the Med-diet pattern and its associated beneficial outcomes in a plethora of several chronic diseases that are either directly or indirectly related to inflammation. These studies refer to heart failure, CVD [ 25 ], cancer [ 26 , 27 ], obesity [ 28 ], metabolic syndrome [ 29 , 30 , 31 ], diabetes [ 31 , 32 , 33 , 34 ], and other subsequent manifestations such as diabetic retinopathy [ 35 ], asthma [ 36 ], autoimmune diseases such as rheumatoid arthritis [ 37 ], incident frailty risk [ 38 ], non-alcoholic fatty liver disease [ 39 , 40 ], inflammatory bowel disease [ 41 ], cognitive health, the risk of Alzheimer’s disease and dementia [ 42 , 43 , 44 ], and age-related macular degeneration [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammation, not Cholesterol, Is a Cause of Chronic Disease

2018

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Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in relation to the development of chronic diseases have been somewhat demonised. However, the principles of the Mediterranean diet and relevant data linked to the examples of people living in the five blue zones demonstrate that the key to longevity and the prevention of chronic disease development is not the reduction of dietary or serum cholesterol but the control of systemic inflammation. In this review, we present all the relevant data that supports the view that it is inflammation induced by several factors, such as platelet-activating factor (PAF), that leads to the onset of cardiovascular diseases (CVD) rather than serum cholesterol. The key to reducing the incidence of CVD is to control the activities of PAF and other inflammatory mediators via diet, exercise, and healthy lifestyle choices. The relevant studies and data supporting these views are discussed in this review.

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Section: Introductionmentioning

confidence: 99%

Inflammation, not Cholesterol, Is a Cause of Chronic Disease

2018

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“…Several studies have been done to find an appropriate strategy to control the disease symptoms and inflammation in patients with UC [8]. Patients with UC might take benefit from the consumption of fish oils, polyunsaturated fatty acids, and probiotics [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effects of soy milk consumption on gut microbiota, inflammatory markers, and disease severity in patients with ulcerative colitis: a study protocol for a randomized clinical trial

Sadeghi

Milajerdi

Siadat

et al. 2020

Trials

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Background: Several strategies are recommended to alleviate clinical symptoms of ulcerative colitis (UC). Soy milk may affect UC through its anti-inflammatory properties. However, no study has examined the effects of soy milk consumption on gut microbiota and inflammatory biomarkers in patients with UC. The current study will be done to examine the effects of soy milk consumption on UC symptoms, inflammation, and gut microbiota in patients with UC. Methods: This study is a randomized clinical trial, in which thirty patients with mild to moderate severity of UC will be randomly allocated to receive either 250 mL/day soy milk plus routine treatments (n = 15) or only routine treatments (n = 15) for 4 weeks. Assessment of anthropometric measures and biochemical indicators including serum concentrations of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interferon gamma (IFN-γ) will be done at the study baseline and end of trial. In addition, the quantity of butyrate-producing bacteria including Clostridium cluster IV, Faecalibacterium prausnitzii, and Roseburia spp.; prebiotic bacteria including Lactobacillus spp. and Bifidobacteria spp.; and mucus-degrading bacteria including Akkermansia muciniphila, Bacteroides fragilis, and Ruminococcus spp., as well as calprotectin and lactoferrin levels, will be explored in fecal samples. Also, the Firmicutes to Bacteroidetes ratio which is of significant relevance in human gut microbiota composition will be assessed. Discussion: Altered gut microbiota has been reported as an important contributing factor to inflammation in patients with inflammatory bowel disease (IBD). Soy milk contains several components such as phytoestrogens with potential antiinflammatory properties. This product might affect gut microbiota through its protein and fiber content. Therefore, soy milk might beneficially affect systemic inflammation, gut microbiota, and then clinical symptoms in patients with UC.

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“…In patients with UC, a prospective cohort study of 191 patients revealed that high intake of processed and red meat, protein, alcohol, and high sulfur or sulfate increased the likelihood of relapse [ 123 ]. Thus, avoidance of specific food items should be based on individual experience, and no generalized recommendation can be made [ 124 ]. Milk should not be routinely restricted in all patients with inflammatory bowel disease unless patient has severe hypolactasia.…”

Section: The Asian Working Group Guidelines Regarding Diet In Inflammmentioning

confidence: 99%

Diet and inflammatory bowel disease: The Asian Working Group guidelines

Sood

Ahuja

Kedia

et al. 2019

Indian J Gastroenterol

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Introduction These Asian Working Group guidelines on diet in inflammatory bowel disease (IBD) present a multidisciplinary focus on clinical nutrition in IBD in Asian countries. Methodology The guidelines are based on evidence from existing published literature; however, if objective data were lacking or inconclusive, expert opinion was considered. The conclusions and 38 recommendations have been subject to full peer review and a Delphi process in which uniformly positive responses (agree or strongly agree) were required. Results Diet has an important role in IBD pathogenesis, and an increase in the incidence of IBD in Asian countries has paralleled changes in the dietary patterns. The present consensus endeavors to address the following topics in relation to IBD: (i) role of diet in the pathogenesis; (ii) diet as a therapy; (iii) malnutrition and nutritional assessment of the patients; (iv) dietary recommendations; (v) nutritional rehabilitation; and (vi) nutrition in special situations like surgery, pregnancy, and lactation. Conclusions Available objective data to guide nutritional support and primary nutritional therapy in IBD are presented as 38 recommendations.

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The Role of Diet in Inflammatory Bowel Disease

Abstract: G&H What is the current understanding of the pathogenesis of inflammatory bowel disease? Does diet play a role?

Cited by 43 publications

References 42 publications

Inflammation, not Cholesterol, Is a Cause of Chronic Disease

Inflammation, not Cholesterol, Is a Cause of Chronic Disease

Effects of soy milk consumption on gut microbiota, inflammatory markers, and disease severity in patients with ulcerative colitis: a study protocol for a randomized clinical trial

Diet and inflammatory bowel disease: The Asian Working Group guidelines

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