The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

Abstract

Neurological diseases are recognized as major causes of disability and mortality worldwide. Due to the dynamic progress of diseases such as Alzheimer’s disease (AD), Parkinson’s Disease (PD), Schizophrenia, Depression, and Multiple Sclerosis (MD), scientists are mobilized to look for new and more effective methods of interventions. A growing body of evidence suggests that inflammatory processes and an imbalance in the composition and function of the gut microbiome, which play a critical role in the pathogenesis of various neurological diseases and dietary interventions, such as the Mediterranean diet the DASH diet, or the ketogenic diet can have beneficial effects on their course. The aim of this review was to take a closer look at the role of diet and its ingredients in modulating inflammation associated with the development and/or progression of central nervous system diseases. Presented data shows that consuming a diet abundant in fruits, vegetables, nuts, herbs, spices, and legumes that are sources of anti-inflammatory elements such as omega-3 fatty acids, polyphenols, vitamins, essential minerals, and probiotics while avoiding foods that promote inflammation, create a positive brain environment and is associated with a reduced risk of neurological diseases. Personalized nutritional interventions may constitute a non-invasive and effective strategy in combating neurological disorders.

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

“…Healthy dietary patterns that are rich in fiber and beneficial nutrients may reduce the risk of disease, while unhealthy dietary patterns may increase the risk of disease and worsen clinical outcomes. 309 Here, we summarize preclinical and human studies revealing the implications and mechanisms of various dietary patterns on other diseases in addition to cancer, including neurodegenerative diseases, autoimmune diseases, CVD, and metabolic disorders.…”

Educommunication in nutrition and neurodegenerative diseases: a scoping review protocol

“…Deficiency of energy, nutrients and bioactive compounds accentuates pathophysiological processes such as inflammation, oxidative stress, gut dysbiosis and immune dysfunction, while proper nutrition can prevent, mitigate or slow down the progression of NDs. 5 6 This fact highlights the importance of diet and nutrition for patients with NDs.…”

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

“…Given a growing focus on the potential importance of diet-related inflammation, the dietary inflammatory index (DII) was designed as a tool capable of capturing and representing the impact of different dietary factors on the production of inflammatory biomarkers including C-reactive protein (CRP), interleukin (IL)-1β, IL-4, IL-6, IL-10, and tumor necrosis factor (TNF)-a ( 13 ). The DII provides a comprehensive estimate of the inflammatory potential of a given diet based on the consumption of foods with anti- or pro-inflammatory effects, with higher values being indicative of a diet that is potentially more inflammatory ( 14 , 15 ). The composite dietary antioxidant index (CDAI) is another index that captures information regarding the antioxidant properties of a given diet ( 16 ), with diets rich in selenium, zinc, and other antioxidants being better suited to mitigating oxidative stress, potentially leading to a reduction in gallstone incidence ( 17 , 18 ).…”