The Role of Diet and Lifestyle in Colorectal Cancer Incidence and Survival

Vallis, Jillian

doi:10.36255/exon-publications-gastrointestinal-cancers-diet-colorectal-cancer

Cited by 5 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inverse association between physical activity and CRC incidence was suggested by several observational studies with RR reduction of 0.30 to 0.50 and similar findings in men and women [69][70][71]. The association between sedentary lifestyle and CRC risk may be partly explained by higher rates of obesity, higher plasma glucose levels, insulin resistance, and abnormal intestinal peristalsis in individuals with sedentary lifestyle [72]. Further investigations, especially clinical trials, are needed to clarify this association.…”

Section: Sedentary Lifestylesupporting

confidence: 52%

“…In addition, the processing of meat (e.g., curing or smoking) may cause the formation of different carcinogens, including N-nitroso compounds and polycyclic aromatic hydrocarbons [74]. High intake of red and processed meat will expose the colorectal mucosa to these carcinogens, resulting in an increase in the risk of CRC [72]. High intake of dietary fat, especially from animal sources, was also suggested as another dietary risk factor for CRC [79,80], although another meta-analysis reported no association between dietary fat intake and the risk of CRC [81].…”

Section: Unhealthy Diet (High Intake Of Red and Processed Meat And Fat)mentioning

confidence: 99%

“…Dietary factors: Different studies suggested protective effects of diets high in fruits and vegetables in CRC [153][154][155][156][157], with about a 50% decrease in the risk of CRC in individuals with the highest intake [158,159]. The risk of CRC was significantly lower in individuals with vegetarian diets compared with non-vegetarians [72,160,161]. Dairy products are another dietary factor for which CRC protective effects were consistently reported [72,73,162].…”

Section: Increasing Protective Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention

Roshandel,

Ghasemi-Kebria,

Malekzadeh

2024

Cancers

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer mortality worldwide. There are disparities in the epidemiology of CRC across different populations, most probably due to differences in exposure to lifestyle and environmental factors related to CRC. Prevention is the most effective method for controlling CRC. Primary prevention includes determining and avoiding modifiable risk factors (e.g., alcohol consumption, smoking, and dietary factors) as well as increasing protective factors (e.g., physical activity, aspirin). Further studies, especially randomized, controlled trials, are needed to clarify the association between CRC incidence and exposure to different risk factors or protective factors. Detection and removal of precancerous colorectal lesions is also an effective strategy for controlling CRC. Multiple factors, both at the individual and community levels (e.g., patient preferences, availability of screening modalities, costs, benefits, and adverse events), should be taken into account in designing and implementing CRC screening programs. Health policymakers should consider the best decision in identifying the starting age and selection of the most effective screening strategies for the target population. This review aims to present updated evidence on the epidemiology, risk factors, and prevention of CRC.

show abstract

Section: Sedentary Lifestylesupporting

confidence: 52%

Section: Unhealthy Diet (High Intake Of Red and Processed Meat And Fat)mentioning

confidence: 99%

Section: Increasing Protective Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention

Roshandel,

Ghasemi-Kebria,

Malekzadeh

2024

Cancers

View full text Add to dashboard Cite

show abstract

“…Many studies have concentrated on the impacts of specific exposure factors on CRC occurrences. [24][25][26] This study explored modifiable risk factors for high-risk groups of CRC using IPTW with strong casual validity to bridge this knowledge gap. This study has several noteworthy research outcomes, based on the traditional logistic regression and IPTW method.…”

Section: Discussionmentioning

confidence: 99%

Modifiable Risk Factors in High-Risk Groups of Colorectal Cancer Screening: A Cross-Sectional Study with Propensity Score Method

Zhong,

Feng,

Ouyang

et al. 2023

RMHP

View full text Add to dashboard Cite

Aim The rising incidence and death rate of colorectal cancer (CRC) have posed a severe danger to the lives and health of residents. Individuals at high risk of CRC are drawing growing attention as the majority of the population impacted by CRC. Hence, it is imperative to examine the detection rates and modifiable factors affecting the populations at high risk for CRC in Shenzhen. Methods The multi-stage stratified cluster sampling method was used to select residents aged 45–74 years old from September 2020 to December 2021. The community-based CRC screening was attended by a total of 30,921 residents from urban and suburb regions. The association between modifiable risk factors and the detection rate of high-risk groups was analyzed using multinomial logistic regression with the inverse probability treatment weighting (IPTW) based on the propensity score. Results The cross-sectional analysis included 24,613 people after excluding 6308 people who had missing or invalid fecal occult blood test (FOBT) results. The detection rate for high-risk groups during CRC screening was 28.50%. Higher rate of high-risk groups was detected among those who were male, aged 60 or above, college or above, other marital status, and living in urban ( P < 0.05). Demographic characteristics after IPTW showed a weak correlation coefficient with the detection rate of CRC high-risk both in high-risk and general-risk groups (SMD < 0.1), suggesting a balanced group of participants. The results of logistic regression with IPTW indicated that smoking, drinking, obesity, lack of exercise, vegetable or fruit eating infrequently, red meat, processed meat, cereal food and their clustering status were more inclined to be risk indicators of CRC ( P < 0.05). Conclusion The detection rate for high-risk CRC groups was comparatively high in Shenzhen. The distribution characteristics of lifestyle and dietary risk factors of high-risk groups should be given consideration when adopting individualized intervention measures and comprehensive prevention and control strategies.

show abstract

“…Physical exercise, when properly performed in moderation and in conjunction with an anti-inflammatory diet such as the traditional Mediterranean diet, also has an essential role in preventing and fighting cancer, as has been shown by various epidemiological, observational, and meta-analysis studies [ 28 , 29 ]. Consistent exercise alters several biochemical markers associated with cancer cell metabolism [ 30 ].…”

Section: Physical Activity and Cancermentioning

confidence: 99%

The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer

Divella¹,

Marino

Infusino

et al. 2023

Nutrients

View full text Add to dashboard Cite

A healthy diet and an active lifestyle are both effective ways to prevent, manage, and treat many diseases, including cancer. A healthy, well-balanced diet not only ensures that the body gets the right amount of nutrients to meet its needs, but it also lets the body get substances that protect against and/or prevent certain diseases. It is now clear that obesity is linked to long-term diseases such as heart disease, diabetes, and cancer. The main reasons for people being overweight or obese are having bad eating habits and not moving around enough. Maintaining weight in the normal range may be one of the best things to avoid cancer. It has been scientifically proven that those who perform regular physical activity are less likely to develop cancer than those who lead a sedentary lifestyle. Moving regularly not only helps to maintain a normal body weight, avoiding the effects that favor tumor growth in overweight subjects, but also makes the immune system more resistant by counteracting the growth of tumor cells. Physical activity also helps prevent cardiovascular and metabolic diseases. In this review, it is highlighted that the association between the Mediterranean diet and physical activity triggers biological mechanisms capable of counteracting the low-grade chronic inflammation found in patients with cancer. This assumes that healthy lifestyles associated with cancer therapies can improve the expectations and quality of life of cancer patients.

show abstract

The Role of Diet and Lifestyle in Colorectal Cancer Incidence and Survival

Cited by 5 publications

References 43 publications

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention

Modifiable Risk Factors in High-Risk Groups of Colorectal Cancer Screening: A Cross-Sectional Study with Propensity Score Method

The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer

Contact Info

Product

Resources

About