The Role of Diabetogenic Hyperinsulinism in Nocturnal Angina Pectoris, With Special Reference to the Etiology of Ischemic Heart Disease*

Roberts, H. J.

doi:10.1111/j.1532-5415.1967.tb01194.x

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…By my most conservative estimate, it afllicts no less than one-third of the general population, and no less than half of those over 50 years. 4,10-12 5. I believe that the greatest and most pressing current need in a national study seeking to ascertain the contributory or permissive role of diet in the pathogenesis of ischemic heart disease is a clarification of the influence of sugar consumption.…”

Section: Dietary Fatmentioning

confidence: 95%

“…It is therefore probable the lower blood cholesterol levels found in Dutch Trappist monks, as compared with Benedictine monks,39 represent not only their lowered consumption of saturated fat, but also their high bread and legume (beans) intake and low sugar consumption. 5. Kuo4° found evidence for increased endogenous lipogenesis from carbohydrate in more than 90 per cent of 286 patients with hyperglyceridemia.…”

Section: Dietary Fatmentioning

confidence: 98%

“…Accordingly, cholesterol concentrations may be maintained even without its ingestion. (5) Elevated cholesterol levels cannot be casually equated with increased cholesterol intake. For example, an equal amount of cholesterol in meat or penguin's eggs does not raise the serum cholesterol to the same degree as chicken eggs.…”

Section: Dietary Fatmentioning

confidence: 99%

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Are the Massive Diet Fat-Heart and Coronary Drug Studies Justified?

Roberts

1968

Angiology

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&dquo;When a thing ceases to be a subject of controversy, it ceases to be a < subject of interest.&dquo; &dquo;I will be harsh as truth and as uncompromising as justice. I am in earnest, ' I will not equivocate. ' I will not excuse. ' I will not retreat a single inch, and I will be heard.&dquo; -William Lloyd Garrison As a clinician, researcher, and citizen, I voice my dismay and objections concerning two massive projects that promise to rank among the most flagrant examples of Parkinson's law in medical research. One relates to a 5-year nationwide study aimed at conclusively establishing a relationship between (1) dietary cholesterol and saturated-unsaturated fat intake, (2) the serum cholesterol-lipid concentrations and (3) the incidence of cardiovascular complications in hypercholesterolemic and other high risk individuals. It will involve upwards of 100,000 men ranging in age from 40 to 59 years, selected largely on their having serum cholesterol concentrations exceeding 250 mg/ 100 ml.l This vast effort has been supportea buth by the medical profession and a Congress on the basis of perspectives that have not been totally objective and critical. Such support is understandable, however, when one considers that the study has been championed by a coalition of well known investigators involved in an earlier pilot diet-heart &dquo;feasibility&dquo; study,2 various governmental agencies, and several national health organizations-for all of whom it represents a pet project with many emotional and economic survival overtones. The estimated 50 million dollar cost of this study' obviously can be regarded as only a minimal reference point concerning the actual ultimate expenditures.Concomitantly, at least 50 institutions and medical centers have committed themselves to a national &dquo;coronary drug project&dquo; wherein four types of lipid-lowering agents are being administered to 8500 patients with previous myocardial infarction. The drugs include chlorophenoxyisobutyrate, nicotinic acid, conjugated equine estrogens and dextrothyroxine. This 9-year computerized study has been financed by 35 million dollars appropriated by Congress.3 3 On the basis of many studies and much data, including my own, I con-

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Section: Dietary Fatmentioning

confidence: 95%

Section: Dietary Fatmentioning

confidence: 98%