The role of depression in the insomnia of people with subjective memory impairment, mild cognitive impairment, and dementia in a community sample of elderly individuals in South Korea

Kim, Won-Hyoung; Kim, Jihyun; Kim, Byung Soo; Chang, Sung-Man; Lee, Dong Hoon; Cho, Maeng-Je; Bae, Jae Nam

doi:10.1017/s1041610216002076

Cited by 13 publications

(24 citation statements)

References 49 publications

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“…Chronic insomnia induced by anxiety and depression is associated with memory impairment, dementia and inattention, including impaired alerting behaviour, orienting and executive control. [38][39][40] Similarly, OSA-related chronic intermittent hypoxia and hypercapnia can also hinder attention, memory and cognition. 41,42 Specifically, how SPD generates cognitive and behavioural dysfunction is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sleep Disorder on Delirium in Post-Cardiac Surgery Patients

Wang

Zhang

Luo

et al. 2020

Can. J. Neurol. Sci.

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Background: Post-cardiac surgery patients exhibit a higher incidence of postoperative delirium (PD) compared to non-cardiac surgery patients. Patients with various cardiac diseases suffer from preoperative sleep disorder (SPD) induced by anxiety, depression, breathing disorder, or other factors. Objective: To examine the effect of sleep disorder on delirium in post-cardiac surgery patients. Methods: We prospectively selected 186 patients undergoing selective cardiac valve surgery. Preoperative sleep quality and cognitive function of all eligible participants were assessed through the Pittsburgh Sleep Quality Index (PSQI) and the Montreal Cognitive Assessment, respectively. The Confusion Assessment Method for Intensive Care Unit was used to assess PD from the first to seventh day postoperatively. Patients were divided into two groups according to the PD diagnosis: (1) No PD group and (2) the PD group. Results: Of 186 eligible patients, 29 (15.6%) were diagnosed with PD. A univariate analysis showed that gender (p = 0.040), age (p = 0.009), SPD (p = 0.008), intraoperative infusion volume (p = 0.034), postoperative intubation time (p = 0.001), and intensive care unit stay time (p = 0.009) were associated with PD. A multivariate logistic regression analysis demonstrated that age (odds ratio (OR): 1.106; p = 0.001) and SPD (OR: 3.223; p = 0.047) were independently associated with PD. A receiver operating characteristic curve demonstrated that preoperative PSQI was predictive of PD (area under curve: 0.706; 95% confidence interval: 0.595–0.816). A binomial logistic regression analysis showed that there was a significant association between preoperative 6 and 21 PSQI scores and PD incidence (p = 0.009). Conclusions: Preoperative SPD was significantly associated with PD and a main predictor of PD.

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Section: Discussionmentioning

confidence: 99%

Effect of Sleep Disorder on Delirium in Post-Cardiac Surgery Patients

Wang

Zhang

Luo

et al. 2020

Can. J. Neurol. Sci.

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“…Third, the SMC was assessed only based on the 10th question of the SGDS‐K. Kim et al 25 . defined SMC in the same way.…”

Section: Discussionmentioning

confidence: 99%

“…Second, the effects of depression should be considered 23 . It has been reported that SMC is mainly a product of depressive symptoms and is weakly related to objective dysfunction 1, 24–26 . Third, the confounding effect of demographic variables that may affect SMC should be noted.…”

Section: Introductionmentioning

confidence: 99%

“…23 It has been reported that SMC is mainly a product of depressive symptoms and is weakly related to objective dysfunction. 1,[24][25][26] Third, the confounding effect of demographic variables that may affect SMC should be noted. Demographic variables such as age, 27 gender, 27 education, 27 marital status 28 , alcohol, 28 and smoking 28 can simultaneously affect both objective cognitive decline and SMC.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between subjective memory complaint and executive function in a community sample of South Korean elderly

Kim

Chang

et al. 2020

Psychogeriatrics

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The aim of this study was to investigate the association between subjective memory complaint (SMC) and executive function in a community sample of South Korean elderly. Method: Data for 1442 non-cognitive impaired elderly individuals aged 65 and over were selected from a nationwide dementia epidemiological study conducted in South Korea. Global cognitive function was assessed by the Korean version of the Mini-Mental State Examination (MMSE-KC). The registration and recall subscales of the MMSE were used for evaluating memory function. Executive function was measured by using the Initiation/ Perseveration (IP) subscale of the Korean dementia rating scale (K-DRS). Results: Of the 1442 participants, 1088 were in the normal control group and 354 were in the SMC group. In the SMC group, compared to the normal control group, the proportion of depression was significantly higher, total MMSE scores, delayed recall score and total IP scores were significantly lower, and the mean scores of complex/simple verbal IP, alternating movements, and graphomotor design were lower. In the unadjusted linear regression model, the SMC significantly associated with a lower score of total MMSE-KC, MMSE delayed recall, K-DRS IP, complex/simple verbal IP, alternating movements and graphomotor design. After adjusting for age, gender, education, marital status, alcohol consumption, smoking behaviour, and depression, the SMC were significantly associated with lower total MMSE score, MMSE delayed recall, K-DRS IP, and K-DRS complex/simple verbal IP. Conclusion: In this population-based sample, individuals with SMC had evidence of lower performance on global cognition, memory function, and executive function, especially verbal fluency, after adjusting for demographic variables and depression.

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“…The prevalence of elderly insomnia in China is 47.2% (5) and 57% in America (6). Insomnia severely affects the physical health and life quality of the elderly (7)(8)(9)(10)(11) and increases social and economic burden (6).…”

Section: Introductionmentioning

confidence: 99%

Establishment of a rat model with ageing insomnia induced by D‑galactosef and para‑chlorophenylalanine

et al. 2020

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The current study aimed to establish a rat model of ageing insomnia induced by D-galactose and/or para-chlorophenylalanine. Following establishment of the model, body weights were measured, and Morris water maze and pentobarbital-induced sleep tests were performed. The serum levels of inflammatory mediators and the neural levels of neurotransmitters were detected. The results demonstrated that the body weights of PCPA+D-gal-induced ageing insomnia rats decreased significantly. Ageing insomnia rats exhibited longer latencies to the platform in the Morris water maze tests and fewer target crossings. The sleep latency of the model rats was longer and sleep time was shorter by contrast. The relative expression of hippocampal IL-6, TNF-α, NF-κB and mGluR2 mRNA of the PCPA+D-gal-induced ageing insomnia group was higher, while the relative expression of 5-HT 1A R and GABA A R a1 mRNA were lower. The serum levels of IL-1β, IL-6, TNF-α and brain level of glutamate increased in the PCPA+D-gal-induced ageing insomnia group, while the levels of 5-HT and GABA decreased. In conclusion, memory function, sleep time, expression of inflammatory factors and neurotransmitters are altered in ageing insomnia rats induced by D-galactose and para-chlorophenylalanine, indicating the successful establishment of a murine model of ageing insomnia.

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The role of depression in the insomnia of people with subjective memory impairment, mild cognitive impairment, and dementia in a community sample of elderly individuals in South Korea

Abstract: Insomnia is a very common complaint in the elderly with SMI, MCI, and dementia. Depression might play an important factor in the relationship between insomnia and cognitive dysfunctional status in the elderly.

Cited by 13 publications

References 49 publications

Effect of Sleep Disorder on Delirium in Post-Cardiac Surgery Patients

Effect of Sleep Disorder on Delirium in Post-Cardiac Surgery Patients

Relationship between subjective memory complaint and executive function in a community sample of South Korean elderly

Establishment of a rat model with ageing insomnia induced by D‑galactosef and para‑chlorophenylalanine

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