The role of dendritic cell subsets in 2,4,6-trinitrobenzene sulfonic acid-induced ileitis

Hoshino, Shoichi; Inaba, Muneo; Iwai, Hiroshi; Ito, Tomoki; Li, Ming; Gershwin, M. Eric; Okazaki, Kazuichi; Ikehara, Susumu

doi:10.1016/j.jaut.2009.10.002

Cited by 8 publications

(12 citation statements)

References 49 publications

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“…1a and in our previous paper [1], three subsets of DCs (PIR-A/B high , PIR-A/B med , and PIR-A/B -) were clearly observed in the CD11c ? /B220 -conventional DCs (cDCs) on day 3 (3 days after the induction of ileitis by TNBS), and the PIR-A/B med cDC subset significantly increased at the final stage of inflammation (on day 7).…”

Section: Resultssupporting

confidence: 51%

“…Small intestine (SI)-derived DC-enriched cells were isolated as previously described [1,8]. The cells were stained with fluorescein isothiocyanate (FITC)-conjugated mAb against CD11c (BD Biosciences, San Jose, CA), phycoerythrin (PE)-conjugated anti-CD11c, -CD103, PIR-A/B (BD Biosciences), PIR-B (clone 326414: R&D Systems, Inc., Minneapolis, USA), and allophycocyanin (APC)-conjugated anti-CD45R (B220) (BD Biosciences), -CD11b, -CD83 mAbs (eBioscience Inc., San Diego, CA), -CD40, -CD86, and -CD197 mAbs (CCR7), Alexa Fluor 647-conjugated anti-CD54 mAbs, PE/Cy7-conjugated anti-CD86 mAbs (BioLegend, San Diego, CA, USA), -CD45R (B220) (BD Biosciences), PIR-A/B (BD Biosciences), and anti-CX3CR1 Abs (ProSci inc., Flint Place Poway, CA, USA).…”

Section: Surface Marker Analysesmentioning

confidence: 99%

“…Ileitis was induced by the injection of TNBS (Wako Pure Chemical Industries, Ltd., Osaka, Japan) as described previously [1,9]. Briefly, the mice underwent a laparotomy under anesthesia.…”

Section: Induction Of Ileitismentioning

confidence: 99%

“…Previously, we examined the kinetic movement of DCs in the lamina propria from the viewpoint of their expression of dual-functioning paired immunoglobulin-like receptors (PIR) in the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced ileitis model (an animal model of Crohn's disease) [1]. We observed three subsets of DCs (PIR-A/ B high , PIR-A/B med , and PIR-A/B -) in the CD11c ?…”

Section: Introductionmentioning

confidence: 99%

“…In our previous paper, we examined the role of the immunoregulatory PIR-A/B med DC subset on the expression of some surface markers [1]. Recently, a new classification of DCs has been emerging-one based mainly on the origin of the DC subsets.…”

Section: Introductionmentioning

confidence: 99%

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Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells

et al. 2011

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Section: Resultssupporting

confidence: 51%

Section: Surface Marker Analysesmentioning

confidence: 99%

“…Ileitis was induced by the injection of TNBS (Wako Pure Chemical Industries, Ltd., Osaka, Japan) as described previously [1,9]. Briefly, the mice underwent a laparotomy under anesthesia.…”

Section: Induction Of Ileitismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells

et al. 2011

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Liver Immunology

Bogdanos

Gao

Gershwin

2013

Comprehensive Physiology

175

130

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The liver is the largest organ in the body and is generally regarded by non-immunologists as not having lymphoid function. However, such is far from accurate. This review highlights the importance of the liver as a lymphoid organ. Firstly, we discuss experimental data surrounding the role of liver as a lymphoid organ. The liver facilitates a tolerance rather than immunoreactivity, which protects the host from antigenic overload of dietary components and drugs derived from the gut and is also instrumental to fetal immune tolerance. Loss of liver tolerance leads to autoaggressive phenomena which if are not controlled by regulatory lymphoid populations may lead to the induction of autoimmune liver diseases. Liver-related lymphoid subpopulations also act as critical antigen-presenting cells. The study of the immunological properties of liver and delineation of the microenvironment of the intrahepatic milieu in normal and diseased livers provides a platform to understand the hierarchy of a series of detrimental events which lead to immune-mediated destruction of the liver and the rejection of liver allografts. The majority of emphasis within this review will be on the normal mononuclear cell composition of the liver. However, within this context, we will discus select, but not all, immune mediated liver disease and attempt to place these data in the context of human autoimmunity.

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Immunoregulatory function of PIR-A/B+ DCs in the inflammatory responses of dextran sodium sulfate-induced colitis

et al. 2013

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The role of dendritic cell subsets in 2,4,6-trinitrobenzene sulfonic acid-induced ileitis

Cited by 8 publications

References 49 publications

Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells

Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells

Liver Immunology

Immunoregulatory function of PIR-A/B+ DCs in the inflammatory responses of dextran sodium sulfate-induced colitis

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