The role of default network deactivation in cognition and disease

Antičević, Alan; Cole, Michael W.; Murray, John D.; Corlett, Philip R.; Wang, Xiao Jing; Krystal, John H.

doi:10.1016/j.tics.2012.10.008

Cited by 839 publications

(766 citation statements)

References 105 publications

(155 reference statements)

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“…We observed a clear link with cortical regions that are already recognized as important integrative regions for brain network function. Moreover, they are well known to be relevant for cognitive function, but to be especially vulnerable to atrophy and connectivity loss in MS (Anticevic et al., 2012; He et al., 2009; Steenwijk et al., 2016). In a small subset of patients, we detected as well an association between OCT outcomes and cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS

et al. 2016

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BackgroundNeurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated.ObjectiveTo investigate the association between focal cortical volume and thickness of retinal layers.MethodsFifty‐four patients (relapsing–remitting MS, mean age 40.5 years, mean disease duration 7.6 years, median EDSS 2) underwent OCT and MRI. The association between focal cortical volume and OCT measurements was investigated with voxel‐based morphometry (VBM). Patterns of association were determined with Yeo's functional network atlas and the Harvard‐Oxford cortical atlas. We used GEE models with cortical volumes from the FreeSurfer parcellation to confirm VBM results. Post hoc, we analyzed the association between OCT, focal cortical volumes, and an extended neuropsychological assessment in a subgroup of 14 patients.ResultsMacular retinal nerve fiber layer (mRNFL) and ganglion cell /inner plexiform layer (GCIPL) showed a robust association with mainly the insular cortex and the cingulate cortex. VBM findings were confirmed with FreeSurfer volumes. The post hoc analysis detected significant correlations between both OCT outcomes and cognition.ConclusionBesides the primary visual system, OCT outcomes show a correlation pattern with cortical regions that are known to be important for cognitive performance, predominantly the insula in both hemispheres. Thus, OCT should be further investigated as a marker for neurodegeneration in MS.

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Section: Discussionmentioning

confidence: 99%

Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS

et al. 2016

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“…When a task requires our attention, however, the activation of such network is suppressed (as in our post-target epochs). Deficits in DMN suppression are reported in several mental illnesses, notably anxiety disorders (Anticevic et al, 2012). This observation suggests that difficulties in switching from rest to task are linked to specific symptomatology, e.g.…”

Section: Introductionmentioning

confidence: 99%

Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder

Ottaviani

Watson

Meeten

et al. 2016

Biological Psychology

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Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder.Biological Psychology http://dx.doi.org/10. 1016/j.biopsycho.2016.06.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  Trait worry was inversely related with prefrontal deactivation to target detection. HRV predicted neural activation changes produced by attentional focus switching. A worry induction increased pre-to post-target deactivation of default mode areas. The induction reduced behavioural and neurobiological differences between groups. AbstractGeneralized anxiety disorder (GAD) is characterized by difficulties in inhibiting both perseverative thoughts (worry and rumination) and autonomic arousal. We investigated the neurobiological substrates of such abnormal inhibitory processes, hypothesizing aberrant functional coupling within 'default mode' (DMN) and autonomic brain networks. Functional imaging and heart rate variability (HRV) data were acquired from GAD patients and controls during performance of three tracking tasks interspersed with a perseverative cognition (PC) induction. After detection of infrequent target stimuli, activity within putative DMN hubs was suppressed, consistent with a redirection of attentional resources from internal to external focus. This magnitude of activity change was attenuated in patients and individuals with higher trait PC, but was predicted by individual differences in HRV. Following the induction of PC in controls, this pattern of neural reactivity became closer to that of GAD patients. Results support, at a neural level, the association between cognitive inflexibility and autonomic rigidity.

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“…The DMN was initially considered to represent neural baseline activity until further investigations showed that activity within the DMN is functionally related to internally driven mental states, such as self-referential processing, long-term memory, and mentalizing, and that its deactivation plays a functional role during externally directed tasks (Anticevic et al, 2012;Buckner et al, 2008;Burianova, McIntosh, & Grady, 2010;Kelly et al, 2008;Mennes et al, 2010;Sambataro et al, 2010). In addition, an emerging view suggests that cognitive performance in general might rely on the dynamic interaction between the DMN and two other large-scale neural networks: the fronto-parietal task-positive network (FPN), which is associated with attention and cognitive control, and the salience network (SN) in anterior cingulate and fronto-insular cortex, which is involved in the selection of emotionally and motivationally relevant stimuli (Andrews-Hanna et al, 2014;Chen et al, 2013;Fox et al, 2005;Seeley et al, 2007;Sridharan et al, 2008;Spreng et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Aging and large-scale functional networks: White matter integrity, gray matter volume, and functional connectivity in the resting state

et al. 2015

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Healthy ageing is accompanied by neurobiological changes that affect the brain's functional organization and the individual's cognitive abilities. The aim of this study was to investigate the effect of global age-related differences in the cortical white and gray matter on neural activity in three key large-scale networks. We used functionalstructural covariance network analysis to assess resting state activity in the default mode network (DMN), the fronto-parietal network (FPN), and the salience network show that, in the direct comparison of resting state activity, young but not older adults reliably engage the SN and FPN in addition to the DMN, suggesting that older adults recruit these networks less consistently. Second, our results demonstrate that agerelated decline in white matter integrity and gray matter volume is associated with activity in prefrontal nodes of the SN and FPN, possibly reflecting compensatory mechanisms. We suggest that age-related differences in gray and white matter properties differentially affect the ability of the brain to engage and coordinate largescale functional networks that are central to efficient cognitive functioning.

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The role of default network deactivation in cognition and disease

Cited by 839 publications

References 105 publications

Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS

Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS

Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder

Aging and large-scale functional networks: White matter integrity, gray matter volume, and functional connectivity in the resting state

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