2006
DOI: 10.1177/107327480601300109
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The Role of Cytoreductive Hepatic Surgery as an Adjunct to the Management of Metastatic Neuroendocrine Carcinomas

Abstract: Surgical intervention as part of an aggressive multimodality treatment plan results in improved outcomes for patients with advanced hepatic metastases of neuroendocrine origin. Future directions may include earlier surgical intervention with adjuvant therapies reserved for aggressive recurrent disease.

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Cited by 33 publications
(26 citation statements)
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“…Acute intravenous administration of octreotide has been reported to provide rapid reversal of carcinoid crisis, and current focus of carcinoid crisis therapy is to prevent mediator release with octreotide prophylaxis [1, 2, 6, 7, 14,18,19,20]. This has largely replaced use of other drugs for acute treatment.…”
Section: Small Intestinal Net: Pre- and Perioperative Therapymentioning
confidence: 99%
“…Acute intravenous administration of octreotide has been reported to provide rapid reversal of carcinoid crisis, and current focus of carcinoid crisis therapy is to prevent mediator release with octreotide prophylaxis [1, 2, 6, 7, 14,18,19,20]. This has largely replaced use of other drugs for acute treatment.…”
Section: Small Intestinal Net: Pre- and Perioperative Therapymentioning
confidence: 99%
“…In managing NET with liver metastasis, surgery helps in reducing tumor burden and hormonal secretion in functioning tumor (38,39). If liver metastasis is left untreated, 5-year survival was only 30-40% (40,41). Improved survival has been reported if liver metastasis was resected, especially if complete resection was achieved.…”
Section: Management With Liver Metastasismentioning
confidence: 99%
“…A minority of patients may present with solitary liver metastases or limited liver involvement and in this sub-group of patients surgical resection should be considered. 27 For the majority of patients with diffuse, unresectable disease other modalities of treatment such as embolisation/chemoembolisation, systemic chemotherapy and biological or hormonal agents need to be considered to palliate symptomatic hepatomegaly and hormonal symptoms.…”
Section: Systemic Therapy For Hepatocellular Carcinomamentioning
confidence: 99%