The role of cytoreduction for metastatic and recurrent colorectal cancer in the era of multidisciplinary treatments.

Rationale for Integrated Procedures: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Combined

“…Equally important, cytoreduction stimulates the remaining cells to enter into a proliferative phase that is potentially more responsive to chemotherapy. Hence, the rationale underlying cytoreduction is that the fewer tumor cells left after cytoreduction, the better they respond to chemotherapy [8][9][10]. For various reasons, CRS and IP-CHT must be done at the same time.…”