The role of cytokines and their inhibitors in arthritis

Dayer, Jean‐Michel; Fenner, Helmut

doi:10.1016/s0950-3579(05)80186-4

Cited by 76 publications

(41 citation statements)

References 82 publications

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“…IL-1␤-induced MMP-1 and MMP-3 values were ϳ3-fold and 5-fold greater than A-SAA-induced values, respectively. In previous studies, IL-1␤ was shown to be a potent mediator of MMP production (39,40).…”

Section: Discussionmentioning

confidence: 96%

Local expression of the serum amyloid A and formyl peptide receptor–like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis

O'Hara

Murphy

Whitehead

et al. 2004

Arthritis & Rheumatism

131

118

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Section: Discussionmentioning

confidence: 96%

Local expression of the serum amyloid A and formyl peptide receptor–like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis

O'Hara

Murphy

Whitehead

et al. 2004

Arthritis & Rheumatism

131

118

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“…FLS in the rheumatoid lesion have a broad range of functions, including the production of proinflammatory cytokines such as IL-1 and TNF␣ (3,22,23). Secretion of tissue-damaging MMPs has also been considered to be one of the most important features of FLS (4), and this is thought to contribute to local tissue destruction (3).…”

Section: Discussionmentioning

confidence: 99%

Lymphotoxin β–mediated stimulation of synoviocytes in rheumatoid arthritis

Braun¹,

Takemura²,

Vallejo³

et al. 2004

Arthritis & Rheumatism

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Objective. Lymphotoxin ␤ (LT␤), a cytokine produced by T cells and B cells, plays a central role in the normal development of lymph nodes and is critical in the formation of ectopic germinal center reactions in rheumatoid synovitis. Because resident fibroblast-like synoviocytes (FLS) express receptors for LT␤, we examined the consequences of FLS activation by LT␤.Methods. FLS from patients with rheumatoid arthritis were isolated and examined for the expression of LT␤ receptor. FLS were incubated with LT␣1␤2 and assayed for the production of cytokines and chemokines and the up-regulation of adhesion molecules.Results. Exposure of FLS to recombinant LT␣1␤2 resulted in the production of multiple inflammatory cytokines and metalloproteinases, implicating FLS as amplifiers of the inflammatory process in the inflamed joint. Additionally, LT␣1␤2 was found to up-regulate the expression of cell adhesion molecules, rendering FLS to efficient adhesion substrates for T cells. LT␣1␤2 also induced production of the chemokines CCL2 and CCL5, which elicited transmigration activity of T cells. Upon stimulation with LT␣1␤2, FLS did not acquire characteristics of follicular dendritic cells.Conclusion. These data document that FLS are involved in multiple stages of the inflammatory process, including the recruitment and retention of lymphocytes in the synovial microenvironment. We propose that the heterotypic interaction between LT␤-producing lymphocytes and responding FLS contributes to the establishment of complex lymphoid microstructures, and that this may be one element that defines susceptibility of the synovial membrane to lymphoid organogenesis.

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“…Both soluble receptors are present in blood and urine of normal individuals (Aderka et al, 1992). Elevated circulating levels of these molecules have already been reported in patients with inflammatory diseases such as rheumatoid arthritis (Dayer and Fenner, 1992;Lopez et al, 1995) and in chronic renal failure patients (Descamps-Latscha et al, 1995;Pereira et al, 1994). The biologic functions of these soluble forms of TNF receptors present in plasma are still speculative.…”

Section: Witko-sarsat Et Almentioning

confidence: 99%