The role of cystatin C as a proteasome inhibitor in multiple myeloma

Jiang, Yijing; Zhang, Jie; Zhang, Chenlu; Hong, Lemin; Jiang, Yuchen; Lu, Ling; Huang, Hongming; Guo, Dan

doi:10.1080/16078454.2020.1850973

Cited by 15 publications

(10 citation statements)

References 59 publications

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“…Cystatin C (Cys-C) is a cysteine protease inhibitor that is distributed in various body fluids such as blood and cerebrospinal fluid, and its production is not affected by other physical characteristics or external conditions [ 5 ]. One study [ 6 ] noted that a significant increase in Cys-C levels could be observed in the serum of patients with AKI and correlated with the severity of kidney damage.…”

Section: Introductionmentioning

confidence: 99%

Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury

Liu

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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There is a lack of targeted biomarkers that can diagnose Acute Kidney Injury (AKI) early and accurately, which leads to deterioration of renal function and even death in patients who do not receive timely and effective treatment. In recent years, an increasing number of studies have shown that AKI-related markers such as cystatin C (Cys-C) and retinol-binding protein (RBP) can be used for early diagnosis of AKI to a certain extent. A total of 262 subjects were included in this study, of which 132 patients with traumatic AKI were enrolled in one group and named as the AKI group; 130 healthy subjects were enrolled in another group and named as the healthy group. AKI patients with different conditions were classified into AKI phase I, II, and III according to the KDIGO AKI diagnostic criteria, with 45, 59, and 28 in each group. In this study, we examined and compared serum Cys-C, RBP4, and neutrophil gelatinase-associated lipid transport protein (NGAL) levels between the AKI and healthy groups and between patients with AKI of different conditions, and the correlation and diagnostic value of three serum markers with the condition of traumatic AKI patients were also analyzed. The results showed that serum Cys-C, RBP4, and NGAL were significantly higher in the AKI group compared with the healthy group ( P < 0.05 ), and the mean concentrations of the three serum markers increased as the severity of the disease increased, while correlation analysis showed that all three serum markers were positively correlated with serum Scr levels ( P < 0.001 ). Further ROC curve analysis was performed, and the diagnostic values of serum Cys C, RBP4, and NGAL alone and in combination for traumatic AKI were 0.769, 0.741, 0.771, and 0.905, respectively. In short, serum Cys C, RBP4, NGAL have important value for the assessment and diagnosis of traumatic AKI patients.

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Section: Introductionmentioning

confidence: 99%

Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury

Liu

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…At this stage, the main treatment methods for the MM include symptomatic support therapy, high-dose chemotherapy, bone marrow hematopoietic stem cell transplantation, and cellular immunotherapy [ 5 , 6 ]. In the past decade or so, the selective protease inhibitors (such as bortezomib and carfilzomib) and immunomodulatory drugs (such as lenalidomide) have been widely used, although the median survival period of patients can be extended to six years, but at the same time, the high cost has also increased the financial burden of patients and even caused some patients to refuse treatment [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells

Pan

Luo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The multiple myeloma is a malignant clonal tumor of bone marrow plasma cells that is incurable and inevitably recurrent. The mechanisms of progression include tumor cell metastasis, immune escape, resistance to apoptosis, and malignant proliferation. The cysteine-rich secreted acidic protein is closely related to the growth, development, remodeling, and repair of cells and tissues. In our study, we divided myeloma patients and patients with other blood diseases into groups and measured the cysteine-rich secreted acidic protein (SPARC) content in the serum of different groups of patients as well as the prognostic differences. The U266 cells were transfected with interfering vectors and overexpressed SPARC vectors to determine the physiological functions of MM cells. Our results showed that SPARC was highly expressed in MM and the survival rate of the high SPARC expression group was lower than that of the low expression group. Interfering SPARC vectors inhibited cancer cell proliferation, migration, and invasion and promoted apoptosis. Overexpression of SPARC vectors promoted cancer cell development. SPARC affected the patient’s disease development by regulating the biological behavior of the MM cells.

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“…Likewise, it has been associated with poor prognosis of patients with MM [ 20 ]. Furthermore, there is also increasing evidence that CysC may be associated with bone disease in MM, and it has been proposed as a biomarker and, further, as a potential therapeutic target in this type of cancer [ 13 , 21 ]. CysC has also been shown to identify a subset of ISS-3 score patients with worse outcome [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma

Piorno

González-García

Mendez-Gallego

et al. 2022

Advances in Hematology

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Objectives. The aim of this study was to compare the creatinine equations with cystatin C (CysC) equations to define renal impairment (RI) in newly diagnosed multiple myeloma (MM) patients and to analyse the equation that allows for identifying patients with more and worse prognostic factors. Methods. Renal function was evaluated prospectively in 61 patients with newly diagnosed untreated MM employing CKD-EPI and CAPA equations. The comparison was conducted using Bland–Altman graphics and Cohen’s Kappa statistic. Mann–Whitney T and Chi-square tests were used, and univariate and multivariate analyses were carried out. Results. According to the IMWG criteria, 26% of patients showed RI (3 women/13 men) whilst the use of CysC equations allowed us to identify up to 39% of patients (7 women/17 men). The CAPA equation was less biased and dispersed and more sensitive than CKD-EPI-creatinine. Furthermore, univariate analysis unveiled an association between decreased CKD-EPI-CysC and poor prognosis based on R-ISS-3. Conclusions. The IMWG criteria may underestimate kidney disease, mostly in women, which could affect the dose received as well as its toxicity. Altogether, our data suggest that equations that include CysC are more accurate to detect hidden kidney disease, as well as patients with more and worse prognostic factors, in newly diagnosed MM.

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The role of cystatin C as a proteasome inhibitor in multiple myeloma

Cited by 15 publications

References 59 publications

Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury

Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury

Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells

Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma

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