The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia

Taşkömür, Aysun Tekeli; Erten, Özlem

doi:10.1016/j.tjog.2021.05.007

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…In PE, glomerular endotheliosis gives rise to renal dysfunction due to the disruption of the endothelium and injury to the podocytes [ 11 , 36 ]. Renal damage manifests as HTN, decreased GFR, proteinuria, and SCr elevation.…”

Section: Discussionmentioning

confidence: 99%

Prediction Model for Pre-Eclampsia Using Gestational-Age-Specific Serum Creatinine Distribution

Kang

Hwang

Lee

et al. 2023

Biology

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Pre-eclampsia (PE) is a pregnancy-related disease, causing significant threats to both mothers and babies. Numerous studies have identified the association between PE and renal dysfunction. However, in clinical practice, kidney problems in pregnant women are often overlooked due to physiologic adaptations during pregnancy, including renal hyperfiltration. Recent studies have reported serum creatinine (SCr) level distribution based on gestational age (GA) and demonstrated that deviations from the expected patterns can predict adverse pregnancy outcomes, including PE. This study aimed to establish a PE prediction model using expert knowledge and by considering renal physiologic adaptation during pregnancy. This retrospective study included pregnant women who delivered at the Wonju Severance Christian Hospital. Input variables, such as age, gestational weeks, chronic diseases, and SCr levels, were used to establish the PE prediction model. By integrating SCr, GA, GA-specific SCr distribution, and quartile groups of GA-specific SCr (GAQ) were made. To provide generalized performance, a random sampling method was used. As a result, GAQ improved the predictive performance for any cases of PE and triple cases, including PE, preterm birth, and fetal growth restriction. We propose a prediction model for PE consolidating readily available clinical blood test information and pregnancy-related renal physiologic adaptations.

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Section: Discussionmentioning

confidence: 99%

Prediction Model for Pre-Eclampsia Using Gestational-Age-Specific Serum Creatinine Distribution

Kang

Hwang

Lee

et al. 2023

Biology

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“…25 Besides the aforementioned additive or synergistic risk factor contributing to maternal mobility or mortality in pregnant women with COVID-19, pregnant women often face several unique pregnancy-related complications, such as pregnancy induced hypertension (PIH), preeclampsia, eclampsia, and gestational diabetes mellitus (GDM). [28][29][30][31][32][33][34] Moreover, overweight (obesity) and advanced age (for example, ≥35 years of age) are also frequently noted in modern obstetrics, resulting in worse outcomes of pregnancy. [35][36][37][38][39] All of them have been known as well correlation with adverse pregnancy outcomes, regardless of concomitance with SARS-CoV-2 infection or not.…”

Section: Anatomic Physiologic and Immunologic Changes During Pregnancymentioning

confidence: 99%

“…35–39 All of them have been known as well correlation with adverse pregnancy outcomes, regardless of concomitance with SARS-CoV-2 infection or not. 6,9,11,12,14,26–66…”

Section: Anatomic Physiologic and Immunologic Changes During Pregnancymentioning

confidence: 99%

The impact of COVID-19 in pregnancy: Part I. Clinical presentations and untoward outcomes of pregnant women with COVID-19

Wang

Lee

Yang

et al. 2021

Journal of the Chinese Medical Association

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019, COVID-19) is a pandemic disease with rapidly and widely disseminating to the world. Based on experiences about the H1N1, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) coronavirus pandemics, pregnant women who are infected are disproportionately more likely to develop severe illness and need more hospitalizations, intensive care, and finally die of diseases compared with those nonpregnant counterparts or those pregnant women without infection. Although more than one half of pregnant women with COVID-19 are asymptomatic, and as well as their symptoms are frequently mild, this observation presents a further challenge regarding service provision, prevention, and management, in which this may result in overlooking the risk of COVID-19 during pregnancy. As predictable, despite much advance in critical care in recent decades, during the 2020 COVID-19 pandemic, pregnant women with COVID-19 are really at higher risk to progress to severe illness; require hospitalization; need intensive care, such as the use of mechanical ventilation as well as extracorporeal membrane oxygenation (ECMO), and of most important, die than their nonpregnant counterparts and pregnant women without COVID-19. The magnitude of the risk to pregnant women further extend to their newborn from COVID-19 with resultant significantly increasing perinatal and neonatal morbidity and mortality rates. The heightened risk of untoward outcomes in pregnant women emphasizes an urgent need of national or international recommendations and guidelines to optimize prevention and management strategies for COVID-19 in pregnancy. Active and passive prevention of COVID-19 is approved as effective strategies for women who attempt to be pregnant or during pregnancy. Understanding that pregnant women who are a vulnerable population is essential to improve the care in the novel and urgent COVID-19 pandemic. The current review is a part I to summarize the up-to-date information about the impact of laboratory-confirmed SARS-CoV-2 infection on pregnant women and focus on clinical presentations and untoward pregnancy outcomes of these pregnant women infected with SARS-CoV-2.

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“…(5) En este contexto, la cistatina C es una proteína producida por todas las células nucleadas y actúa como un indicador para evaluar la Tasa de Filtración Glomerular (TFG) su filtración en el glomérulo es constante debido a su carácter catiónico. (6) A diferencia de otros indicadores como la creatinina, su nivel en sangre no se ve tan afectado por elementos externos como edad, género o cantidad de masa muscular. (7) Asimismo, pueden tener una posible relación no solo con la función renal, sino también con el riesgo cardiovascular en pacientes con y sin diabetes.…”

Section: Introductionunclassified

Cystatin C as an early marker of cardiovascular risk in patients with diabetes

Tisalema-Panimboza,

Galárraga-Pérez

2024

Salud, Ciencia y Tecnología

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Introducción: La cistatina C, una proteína con concentración plasmática estable y eliminación renal exclusiva, se ha destacado como un prometedor marcador precoz de riesgo cardiovascular en pacientes diabéticos debido a su relación con la función renal y la inflamación.Objetivo: Identificar en la literatura existente la asociación entre la cistatina C y el riesgo cardiovascular en pacientes con diabetes, evaluando su potencial como marcador mediante una revisión sistemática. Métodos: Se realizaron búsquedas exhaustivas en bases de datos científicos y se seleccionaron diez estudios que cumplieron con los criterios de inclusión. Estos estudios se centraron en la evaluación de los perfiles de expresión de cistatina C y su efectividad como marcador en el diagnóstico y pronóstico de enfermedades cardiovasculares. Se utilizo el Método PRISMA.Resultados: Los estudios revelan que la cistatina C se asocia estrechamente con la diabetes tipo 2, predicción de enfermedades cardiovasculares y proporciona una evaluación precisa de la función renal en pacientes diabéticos, destacando su utilidad como marcador temprano de complicaciones. Además, niveles elevados de cistatina C se correlacionan con mayor mortalidad y riesgo cardiovascular, superando en precisión a otros marcadores tradicionales, lo que la posiciona como un indicador clave en la evaluación integral de riesgo y pronóstico en pacientes diabéticos.Conclusiones: La cistatina C muestra prometedores vínculos con la diabetes y riesgo cardiovascular en pacientes diabéticos, sugiriendo su utilidad como marcador temprano. Aunque ofrece potencial para detectar complicaciones renales y cardíacas, se requieren más investigaciones antes de su implementación clínica generalizada.

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The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia

Cited by 10 publications

References 33 publications

Prediction Model for Pre-Eclampsia Using Gestational-Age-Specific Serum Creatinine Distribution

Prediction Model for Pre-Eclampsia Using Gestational-Age-Specific Serum Creatinine Distribution

The impact of COVID-19 in pregnancy: Part I. Clinical presentations and untoward outcomes of pregnant women with COVID-19

Cystatin C as an early marker of cardiovascular risk in patients with diabetes

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