The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells

Charoenpanich, Adisri; Bodle, Josephine C.; Loboa, Elizabeth G.

doi:10.1002/9781118907474.ch17

The Biology and Therapeutic Application of Mesenchymal Cells 2016

DOI: 10.1002/9781118907474.ch17

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The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells

Adisri Charoenpanich

Josephine C. Bodle

Elizabeth G. Loboa

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2023

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Cited by 1 publication

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Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

Saberi,

Kouhjani,

Mohammadi

et al. 2023

J Nanobiotechnol

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Despite the recent advances in the development of bone graft substitutes, treatment of critical size bone defects continues to be a significant challenge, especially in the elderly population. A current approach to overcome this challenge involves the creation of bone-mimicking scaffolds that can simultaneously promote osteogenesis and angiogenesis. In this context, incorporating multiple bioactive agents like growth factors, genes, and small molecules into these scaffolds has emerged as a promising strategy. To incorporate such agents, researchers have developed scaffolds incorporating nanoparticles, including nanoparticulate carriers, inorganic nanoparticles, and exosomes. Current paper provides a summary of the latest advancements in using various bioactive agents, drugs, and cells to synergistically promote osteogenesis and angiogenesis in bone-mimetic scaffolds. It also discusses scaffold design properties aimed at maximizing the synergistic effects of osteogenesis and angiogenesis, various innovative fabrication strategies, and ongoing clinical studies. Graphical Abstract

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Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

Saberi,

Kouhjani,

Mohammadi

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

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The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells

Cited by 1 publication

References 126 publications

Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

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