The role of curcumin as an inhibitor of oxidative stress caused by ischaemia re-perfusion injury in tetralogy of Fallot patients undergoing corrective surgery

Sukardi, Rubiana; Sastroasmoro, Sudigdo; Siregar, Nurjati C.; Djer, Mulyadi M.; Suyatna, Fransiscus D.; Sadikin, Mohammad; Ibrahim, Niema; Rahayuningsih, Sri Endah; Witarto, Arief Budi

doi:10.1017/s1047951115000360

Cited by 16 publications

(18 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A small study evaluated the effect of allopurinol supplementation in TOF surgery, showing less ROS expression in myocardial tissue, but no difference in MDA concentration in coronary sinus blood was observed [ 161 ]. Also, the use of curcumin, a potent ROS scavenger, in TOF surgery results in decreased c-Jun N-terminal kinase activity in cardiomyocyte nuclei and less caspase-3 expression, which relates to better right and left ventricle systolic function [ 162 ].…”

Section: Antioxidant-based Strategies In Congenital Heart Disease mentioning

confidence: 99%

Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

et al. 2017

View full text Add to dashboard Cite

Oxidative stress (OS) refers to the imbalance between the generation of reactive oxygen species (ROS) and the ability to scavenge these ROS by endogenous antioxidant systems, where ROS overwhelms the antioxidant capacity. Excessive presence of ROS results in irreversible damage to cell membranes, DNA, and other cellular structures by oxidizing lipids, proteins, and nucleic acids. Oxidative stress plays a crucial role in the pathogenesis of cardiovascular diseases related to hypoxia, cardiotoxicity and ischemia–reperfusion. Here, we describe the participation of OS in the pathophysiology of cardiovascular conditions such as myocardial infarction, anthracycline cardiotoxicity and congenital heart disease. This review focuses on the different clinical events where redox factors and OS are related to cardiovascular pathophysiology, giving to support for novel pharmacological therapies such as omega 3 fatty acids, non-selective betablockers and microRNAs.

show abstract

Section: Antioxidant-based Strategies In Congenital Heart Disease mentioning

confidence: 99%

Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

et al. 2017

View full text Add to dashboard Cite

show abstract

“…1,2 A previous study demonstrated that CME-induced local myocardial inflammation is the central link leading to myocardial injury and progressive cardiac dysfunction subsequently. 10 The recent studies on cardiovascular diseases have shown that curcumin exerts multiple cardiovascular protective effects, such as antioxidative stress, 11 anti-inflammation, 12 antiapoptosis, 13 antiheart failure, 14 anticardiac hypertrophy, 15 and antiatherosclerosis. Some endogenous ligands led to the release of inflammatory factors, such as tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β), by activating the toll-like receptor 4 (TLR4) receptor and NF-κB.…”

Section: Introductionmentioning

confidence: 99%

Protective effects and mechanism of curcumin on myocardial injury induced by coronary microembolization

Liu

Huang

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Objective Coronary microembolization (CME) is a common complication during the percutaneous coronary intervention (PCI). CME‐induced local myocardial inflammation and myocardial apoptosis are the primary causes of progressive cardiac dysfunction. Curcumin exerts a protective role in various cardiovascular diseases; however, its effects in CME are yet to be clarified. Therefore, the current study investigated the effects of curcumin on myocardial inflammatory responses, myocardial apoptosis, and cardiac dysfunctions induced by CME in rats. Methods A total of 40 Sprague–Dawley rats were randomly divided into the following groups: Sham operation (sham group), CME group, curcumin, and control with 10 rats in each group. The ascending aortas were clamped, and the CME‐model group was established by injecting microspheres into the apex of the left ventricle. An equivalent amount of normal saline was injected to establish the sham group. The cardiac functions, serum c‐troponin I level, and apoptotic index was examined. Also, the levels of Toll‐like receptor 4 (TLR4), myeloid differentiation primary response 88 (MYD88), nuclear factor κB (NF‐κB) p65, BCL2‐associated X protein (Bax), B‐cell lymphoma 2 (Bcl‐2), cleaved caspase‐3, tumor necrosis factor α (TNF‐α), and interleukin‐1β (IL‐1β) were detected. Results Myocardial dysfunction enhanced serum c‐troponin I, and apoptotic index were induced following CME. Moreover, CME elevated the expression of TLR4, MyD88, NF‐κB p65, cleaved caspase‐3, TNF‐α, and IL‐1β, while the Bcl‐2/Bax ratio decreased. Curcumin reversed these effects by CME, while the gastric lavage control did not exert any effect. Conclusion Curcumin was responsible for the anti‐CME‐induced myocardial injury. The effector mechanism might be related to the reduction of cardiomyocyte apoptosis and inhibition of myocardial inflammatory responses mediated by TLR4/MyD88/NF‐κB signaling pathway.

show abstract

“…Morover, Cu also has been reported to attenuate ischemia reperfusion injury by reducing ischemia reperfusion‐induced mitochondrial oxidative damage through the activation of SIRT1 signaling . Furthermore, Sukardi et al found that Cu could process the cardioprotective effects via the inhibition of the c‐Jun N‐terminal kinase pathway and caspase‐3 in cardiomyocytes, particularly in the ischemia phase . However, there is still no study on whether Cu is beneficial to diabetic cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

“…22 Furthermore, Sukardi et al found that Cu could process the cardioprotective effects via the inhibition of the c-Jun Nterminal kinase pathway and caspase-3 in cardiomyocytes, particularly in the ischemia phase. 23 However, there is still no study on whether Cu is beneficial to diabetic cardiomyopathy. Therefore, our research aims to evaluate the effects of Cu on diabetic cardiomyopathy and explore its possible mechanism.…”

mentioning

confidence: 99%

Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

Yan

Zhou

et al. 2020

IUBMB Life

View full text Add to dashboard Cite

The aim of this study was to investigate the protective effect of curcumin (Cu) on myocardial injury in diabetic cardiomyopathy in vivo and in vitro. Serum and myocardial glucose, inflammatory cytokines, and cardiac function indexes of type 2 diabetes db/db mice were measured. The mechanism of action was confirmed by immunohistochemistry, immunofluorescence, and western blot experiments. H9C2 cells stimulated by glucose (Glu) were used as cell models in vitro. Cu treatment improved glucose tolerance and lipid profile and reduced the production of inflammatory cytokines. In addition, Cu decreased the serum biochemical indexes. Cu inhibits high mobility group box 1 (HMGB1) signaling pathway in db/db mice. Cu treatment also significantly inhibited pa‐induced inflammatory signaling pathway in H9C2 cells. HMGB1 inhibitor or HMGB1 knockdown counteracted the effects of Cu on diabetic cardiomyopathy. The present study showed the protective effects of Cu on myocardial injury via HMGB1 pathway in diabetic cardiomyopathy in vivo and in vitro.

show abstract

The role of curcumin as an inhibitor of oxidative stress caused by ischaemia re-perfusion injury in tetralogy of Fallot patients undergoing corrective surgery

Abstract: Cardioprotective effects of curcumin may include inhibition of the c-Jun N-terminal kinase pathway and caspase-3 in cardiomyocytes, particularly in the ischaemia phase.

Cited by 16 publications

References 31 publications

Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

Protective effects and mechanism of curcumin on myocardial injury induced by coronary microembolization

Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

Contact Info

Product

Resources

About