The role of crosslinking on the physical properties of gelatin based films

Chaibi, Samira; Benachour, Djafer; Merbah, M.; Cagiao, M. E.; Calleja, F. J. Baltá

doi:10.1007/s00396-015-3660-2

Cited by 15 publications

(19 citation statements)

References 31 publications

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“…The addition of glutaraldehyde creates bonds between the gelatin chains, which prevent their conformation into helical structures. This causes a reduction in peak intensity upon addition of the crosslinking agent [50]. It is also noted that the addition of more glutaraldehyde further reduces the peak intensity, indicating that a higher cross-linking degree results in a reduction in the films crystallinity.…”

Section: X-ray Diffractionmentioning

confidence: 95%

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

et al. 2020

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Gelatin extracted from chromium-tanned leather wastes (CTLW) has a lower molar mass because of the more aggressive extraction process needed to disrupt chromium-collagen bonds when compared to gelatin extracted from the bones, skin, and connective tissues of animals. As a consequence, CTLW gelatin is more hydrophilic, thus it is harder to apply in the production of polymers. To overcome this issue, in this study, films produced with starch, CTLW gelatin, commercial gelatin (as a comparative), and their blends were cross-linked with glutaraldehyde. The cross-linking reduced the crystallinity of the films, impairing the reorganization of gelatin chains into a triple helix structure, which balanced the effect of the higher molecular chain, while not altering the films' tensile strength. It increased the elongation at break and reduced the solubility and the swelling degree by up to 53% and 69%, respectively. These results stand as a great advance for the practical use of starch-CTLW gelatin films.

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Section: X-ray Diffractionmentioning

confidence: 95%

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

et al. 2020

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“…Gelatin‐based matrices have been frequently crosslinked with glutaraldehyde (GLU), predominantly by the formation of a strong Schiff's base through a reaction between ε‐amino groups present in lysine and hydroxylysine gelatin residues and formyl groups of the aldehyde . Despite its efficiency in stabilizing collagenous materials, GLU has been considered cytotoxic due to its potential to leave un‐reacted toxic molecules that will release upon in vivo biodegradation .…”

Section: Introductionmentioning

confidence: 99%

“…hydroxylysine gelatin residues and formyl groups of the aldehyde. 11,12 Despite its efficiency in stabilizing collagenous materials, GLU has been considered cytotoxic due to its potential to leave un-reacted toxic molecules that will release upon in vivo biodegradation. 13,14 Consequently, the use of natural agents that are effective in crosslinking gelatin and present non-toxic characteristic is an important factor when considering the application in food packaging materials.…”

mentioning

confidence: 99%

Gelatin capsule residue‐based films crosslinked with the natural agent genipin

et al. 2019

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This study focused on the development and characterization of biodegradable films based on gelatin capsule residue crosslinked with the natural agent genipin extracted from genipap (Genipa americana L.). Their potential on maintaining the quality attributes (level of peroxides, conjugated dienes and trienes and color) of extra‐virgin olive oil under accelerated storage conditions was investigated. Results showed that the genipin‐crosslinked films had a dark blue appearance. Their total soluble matter, water vapor permeability, tensile strength, ultraviolet and visible light barriers and thermal properties were improved in relation to the uncrosslinked film, whereas their moisture content and microstructure were not affected. In general, films presented comparable properties to those of glutaraldehyde‐crosslinked films. The developed films successfully protected the packed oil from primary and secondary oxidation and maintained the color over the storage period. Therefore, this study demonstrated the effectiveness of genipin on improving the properties of gelatin‐based films and the promising application of films as food packaging.

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“…As proof-of-concept, we used purified green fluorescent protein (GFP) to create HC@GFP capsules. The protein was bioconjugated on the capsules as previously described [ 43 ], and was crosslinked using a 0.25% glutaraldehyde solution, a method commonly used in pharmaceutical technology ( Figure 3 ) [ 44 , 45 ]. Similar capsules were produced using bovine serum (FBS) as a sample of alternative protein.…”

Section: Resultsmentioning

confidence: 99%

Design of Polymeric and Biocompatible Delivery Systems by Dissolving Mesoporous Silica Templates

Rodríguez-Ramos

Marín-Caba

Iturrioz-Rodríguez

et al. 2020

IJMS

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There are many nanoencapsulation systems available today. Among all these, mesoporous silica particles (MSPs) have received great attention in the last few years. Their large surface-to-volume ratio, biocompatibility, and versatility allow the encapsulation of a wide variety of drugs inside their pores. However, their chemical instability in biological fluids is a handicap to program the precise release of the therapeutic compounds. Taking advantage of the dissolving capacity of silica, in this study, we generate hollow capsules using MSPs as transitory sacrificial templates. We show how, upon MSP coating with different polyelectrolytes or proteins, fully customized hollow shells can be produced. These capsules are biocompatible, flexible, and biodegradable, and can be decorated with nanoparticles or carbon nanotubes to endow the systems with supplementary intrinsic properties. We also fill the capsules with a fluorescent dye to demonstrate intracellular compound release. Finally, we document how fluorescent polymeric capsules are engulfed by cells, releasing their encapsulated agent during the first 96 h. In summary, here, we describe how to assemble a highly versatile encapsulation structure based on silica mesoporous cores that are completely removed from the final polymeric capsule system. These drug encapsulation systems are highly customizable and have great versatility as they can be made using silica cores of different sizes and multiple coatings. This provides capsules with unique programmable attributes that are fully customizable according to the specific needs of each disease or target tissue for the development of nanocarriers in personalized medicine.

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The role of crosslinking on the physical properties of gelatin based films

Cited by 15 publications

References 31 publications

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

Starch-Leather Waste Gelatin Films Cross-Linked with Glutaraldehyde

Gelatin capsule residue‐based films crosslinked with the natural agent genipin

Design of Polymeric and Biocompatible Delivery Systems by Dissolving Mesoporous Silica Templates

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