The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex

Pulimood, Nisha S.; Rodrigues, Wandilson dos Santos; Atkinson, Devon A.; Mooney, Sandra M.; Medina, Alexandre E.

doi:10.1523/jneurosci.0766-17.2017

Cited by 20 publications

(29 citation statements)

References 59 publications

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“…In short, CREB plays critical roles in brain function (e.g., Frank & Greenberg, 1994; Pullmood, dos Santos Rodriges Jr., Atkinson, Mooney, & Medina, 2017; Yin & Tully, 1996) including the regulation of ODP. Following the activation of cell surface receptors and Ca 2+ channels, various intracellular signaling pathways are mobilized leading to the activation of CREB, which is relatively well‐scrutinized among many activity‐regulated transcription factors (see Figure 4).…”

Section: Creb (Camp Responsive Element Binding Protein) In Regulationmentioning

confidence: 99%

Ocular dominance plasticity: Molecular mechanisms revisited

Kasamatsu

Imamura

2020

J of Comparative Neurology

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Ocular dominance plasticity (ODP) is a type of cortical plasticity operating in visual cortex of mammals that are endowed with binocular vision based on the competition-driven disparity. Earlier, a molecular mechanism was proposed that catecholamines play an important role in the maintenance of ODP in kittens. Having survived the initial test, the hypothesis was further advanced to identify noradrenaline (NA) as a key factor that regulates ODP in the immature cortex. Later, the ODPpromoting effect of NA is extended to the adult with age-related limitations. Following the enhanced NA availability, the chain events downstream lead to the β-adrenoreceptor-induced cAMP accumulation, which in turn activates the protein kinase A. Eventually, the protein kinase translocates to the cell nucleus to activate cAMP responsive element binding protein (CREB). CREB is a cellular transcription factor that controls the transcription of various genes, underpinning neuronal plasticity and long-term memory. In the advent of molecular genetics in that various types of new tools have become available with relative ease, ODP research has lightly adopted in the rodent model the original concepts and methodologies. Here, after briefly tracing the strategic maturation of our quest, the review moves to the later development of the field, with the emphasis placed around the following issues: (a) Are we testing ODP per se? (b) What does monocular deprivation deprive of the immature cortex? (c) The critical importance of binocular competition, (d) What is the adult plasticity? (e) Excitation-Inhibition balance in local circuits, and (f) Species differences in the animal models.

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Section: Creb (Camp Responsive Element Binding Protein) In Regulationmentioning

confidence: 99%

Ocular dominance plasticity: Molecular mechanisms revisited

Kasamatsu

Imamura

2020

J of Comparative Neurology

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“…The development and function of the mammalian brain requires precise control of gene expression (Cholewa-Waclaw et al, 2016; de la Torre-Ubieta and Bonni, 2011; Ziats et al, 2015). Combinatorial interactions of DNA-binding transcription factors (TFs) regulate diverse gene programs that specify neuronal sub-types, develop and refine circuits, and link sensory experience to adaptive responses of the brain (Mazzoni et al, 2013; Molyneaux et al, 2007; Kawashima et al, 2013; Pulimood et al, 2017; Sharma et al, 2019). Additionally, deregulation of TFs contributes to the pathogenesis of neurological diseases (Porter et al, 2018; Ebert and Greenberg, 2013; Li et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors

et al. 2019

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“…In this perspective, CREB, AKT, and cAMP had their signaling increased in the hippocampus after PE protocols at different frequencies (12 days, 4 and 6 weeks). Studies demonstrating the expression of these cellular components play a crucial role in central nervous system development and maturation (Pulimood et al [ 54 ]). In this sense, Jung and Kim [ 55 ] evaluated the effect of forced training on a treadmill without inclination, for thirty minutes in five weeks in animals with sensorimotor restriction.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies

et al. 2020

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Background. Physical exercise (PE) has been associated with increase neuroplasticity, neurotrophic factors, and improvements in brain function. Objective. To evaluate the effects of different PE protocols on neuroplasticity components and brain function in a human and animal model. Methods. We conducted a systematic review process from November 2019 to January 2020 of the following databases: PubMed, ScienceDirect, SciELO, LILACS, and Scopus. A keyword combination referring to PE and neuroplasticity was included as part of a more thorough search process. From an initial number of 20,782 original articles, after reading the titles and abstracts, twenty-one original articles were included. Two investigators evaluated the abstract, the data of the study, the design, the sample size, the participant characteristics, and the PE protocol. Results. PE increases neuroplasticity via neurotrophic factors (BDNF, GDNF, and NGF) and receptor (TrkB and P75NTR) production providing improvements in neuroplasticity, and cognitive function (learning and memory) in human and animal models. Conclusion. PE was effective for increasing the production of neurotrophic factors, cell growth, and proliferation, as well as for improving brain functionality.

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The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex

Cited by 20 publications

References 59 publications

Ocular dominance plasticity: Molecular mechanisms revisited

Ocular dominance plasticity: Molecular mechanisms revisited

Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors

Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies

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