The Role of Contrast-Enhanced Ultrasound in Guiding Radiofrequency Ablation of Hepatocellular Carcinoma

Chan, Adrienne S.; Hegarty, Chris; Klass, Darren; Yoshida, Eric M.; Chung, Stephen W.; Liu, David M.; Ho, Stephen; Harris, Alison

doi:10.1016/j.carj.2014.11.005

Cited by 29 publications

(23 citation statements)

References 26 publications

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“…Venous ultrasound contrast agents are able to enter the microcirculation at the blood capillary level and show high sensitivity, specificity and spatial resolution of the perfusion level in target organs. 15 According to previous studies, CEUS allows immediate assessment of the result of ablation and achieves similar results to those achieved by enhanced CT and enhanced MRI. [15][16][17][18] In our study, RFA achieved a non-enhanced region of over 70% of the initial lesion size when assessed by CEUS.…”

Section: Conservative Treatment Of Adenomyosis Is a Clinical Challengementioning

confidence: 71%

Ultrasound-guided transcervical radiofrequency ablation for symptomatic uterine adenomyosis

Nie

Hou

Ding

et al. 2017

BJR

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Section: Conservative Treatment Of Adenomyosis Is a Clinical Challengementioning

confidence: 71%

Ultrasound-guided transcervical radiofrequency ablation for symptomatic uterine adenomyosis

Nie

Hou

Ding

et al. 2017

BJR

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“…Clinical application of a new perflubutane microbubble contrast agent (Sonazoid®; Daiichi-Sankyo, Japan) has improved the utility of contrast-enhanced sonography-guided RFA as a treatment strategy for HCC [8,9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

Radiofrequency Ablation Guided by Contrast-Enhanced Sonography versus B-Mode Sonography for Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization

Kawasaki¹,

Hata²,

Kinoshita³

et al. 2016

Dig Dis

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Purpose: Contrast-enhanced sonography increases negative enhancement in the Kupffer phase after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We compared contrast-enhanced sonography with B-mode sonography for guidance of radiofrequency ablation (RFA) of HCC after TACE. Methods: After TACE was performed, 18 nodules in 12 patients were treated by B-mode sonography guided RFA, while 22 nodules in 18 patients were treated by contrast-enhanced sonography-guided RFA. Results: The success rate of initial RFA was 83.3% (15/18 nodules) in the B-mode sonography group. On the other hand, the success rate was 100% (22/22 nodules) in the contrast-enhanced sonography group and the difference was significant (p = 0.046). Conclusion: These findings suggest that RFA guided by Kupffer phase contrast-enhanced sonography after TACE is a promising therapeutic option for curing HCC.

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“…14 In particular, CEUS has more advantages in diagnosing lesions of HCC with diameter <1 cm and the diagnostic rate was increased from 53% to 94%. 15 The CEUS can clearly determine the number, nature, range, feeding vessel, size, infiltration range, and other information of the lesions of HCC and provide fairly detailed imaging basis for determination of treatment plan to precisely ensure if the lesions are removed thoroughly.…”

Section: Discussionmentioning

confidence: 99%

The Application Comparison of Contrast-Enhanced Ultrasound and Contrast-Enhanced Computed Tomography in Radiofrequency Ablation Treatment for Hepatocellular Carcinoma

Liu

Wang

Xing

et al. 2019

Cancer Biotherapy and Radiopharmaceuticals

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Objective: To compare the application value of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) in radiofrequency ablation (RFA) for treatment of hepatocellular carcinoma (HCC). Methods: A total of 112 patients with primary HCC were enrolled for the treatment of RFA and they were randomly equally divided into the CEUS group and CECT group. The gender, age, and number and maximum diameter of tumors between the two groups were compared. The median duration of follow-up was 27.0 months and the clinical outcomes were compared. Results: The average examination time period before ablation, of guiding needle insertion and of ablation in the CEUS group were significantly shorter than those in the CECT group ( p < 0.05). The complete ablation rate of the CEUS group was significantly higher than that of the CECT group (86.36% vs. 73.17%, v 2 = 4.618, p = 0.032). There was no comparative difference in the incidence of complications (including fever, infection, pain, and liver injury) between the two groups ( p > 0.05). The relapse rate of the CEUS group was lower and the survival rate was higher than that in the CECT group ( p < 0.05). Conclusions: Compared with the CECT, the RFA for treatment of HCC guided by the CEUS shorten the time of examination and treatment. The immediate postoperative assessment can improve the overall complete ablation rate, reduce the relapse rate, and increase the survival rate, which provides insights for the clinical application.

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The Role of Contrast-Enhanced Ultrasound in Guiding Radiofrequency Ablation of Hepatocellular Carcinoma

Abstract: CEUS increases the conspicuity and provides better characterization of hypervascular HCC that are either not seen or poorly seen on B-mode US, and CEUS provides real-time guidance of RFA with good short-term treatment responses.

Cited by 29 publications

References 26 publications

Ultrasound-guided transcervical radiofrequency ablation for symptomatic uterine adenomyosis

Ultrasound-guided transcervical radiofrequency ablation for symptomatic uterine adenomyosis

Radiofrequency Ablation Guided by Contrast-Enhanced Sonography versus B-Mode Sonography for Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization

The Application Comparison of Contrast-Enhanced Ultrasound and Contrast-Enhanced Computed Tomography in Radiofrequency Ablation Treatment for Hepatocellular Carcinoma

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