The Role of Contrast-Enhanced Ultrasound in Managing Vascular Pathologies

Thakrar, Dixa B.; Sultan, Muhammad Junaid

doi:10.1016/j.jmir.2019.08.010

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…Recently, there has been rapid development in the ultrasound technology, and contrast-enhanced ultrasound technology has been widely used clinically. Common contrast-enhanced ultrasound technologies include hysterography, breast ultrasound contrast, and liver ultrasound contrast [ 6 – 8 ]. However, traditional contrast agents can only diagnose diseases at a macrolevel through enhanced organ imaging and still lack the ability to reflect the characteristics of the disease at the microlevel.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Atherosclerotic Plaques Using Vascular Endothelial Growth Factor Receptor-2 Targeting Antibody Nano-microbubble as Ultrasound Contrast Agent

Wang

Feng

Yang

et al. 2022

Computational and Mathematical Methods in Medicine

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The atherosclerotic plaque is characterized by narrowing of blood vessels and reduced blood flow leading to the insufficient blood supply to the brain. The hemodynamic changes caused by arterial stenosis increase the shearing force of the fibrous cap on the surface of the plaque, thereby reducing the stability of the plaque. Unstable plaques are more likely to promote angiogenesis and increase the risk of patients with cerebrovascular diseases. A timely understanding of the formation and stability of the arterial plaque can guide in taking targeted measures for reducing the risk of acute stroke in patients. It has been confirmed that nano-microbubbles can enter these plaques through the gaps in the patient’s vascular endothelial cells, thereby enhancing the acquisition of ultrasound information for plaque visualization. Therefore, we aim to investigate the diagnostic value of targeted nano-microbubbles for atherosclerotic plaques. This study constructed vascular endothelial growth factor receptor-2 (VEGFR-2) targeting antibody nano-microbubbles and compared its diagnostic value with that of blank nano-microbubbles for atherosclerotic plaques. Studies have found that VEGFR-2 targeting antibody nano-microbubbles can accurately detect the position of plaques. Its detection rate, sensitivity, and specificity for plaques are higher than those of blank nano-microbubbles. Similarly, the peak intensity and average transit time of VEGFR-2 targeting antibody nano-microbubbles were greater than those of blank nano-microbubbles. Therefore, we believe that the combination of VEGFR-2 antibody and nano-microbubbles can enhance the acquisition of ultrasound information on atherosclerotic plaque neovascularization, thereby improving the early diagnosis of unstable plaque.

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Section: Introductionmentioning

confidence: 99%

Diagnosis of Atherosclerotic Plaques Using Vascular Endothelial Growth Factor Receptor-2 Targeting Antibody Nano-microbubble as Ultrasound Contrast Agent

Wang

Feng

Yang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…CEUS is a blood flow imaging modality, and thus can truly reflect vessel distribution inside tissues [12]. It uses microbubbles, which are contrast agents with thin and relatively permeable shells containing high-molecularweight gases that do not readily diffuse or dissolve within the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Ultrasound in the Detection and Evaluation of Maxillofacial Arteriovenous Malformation: A Case Report

Chang,

Weiwei,

Peng

et al. 2023

Advanced Ultrasound in Diagnosis and Therapy

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Arteriovenous malformation (AVM) is a kind of congenital endothelial malformation that results from errors in vascular morphogenesis. Here we present a case of maxillofacial AVM in a 19-year-old male for its imaging characteristics on contrast-enhanced ultrasound (CEUS). On conventional ultrasound, the lesion was a large subcutaneous mass with abnormal vasculature. On CEUS, it manifested as a "quick wash-in and slow wash-out" enhancement. Moreover, CEUS showed a much larger range of the lesion than gray-scale imaging, with left ophthalmic artery involved. CEUS enabled real-time observation of the microcirculatory perfusion of the lesion and played a very important role in the detection and evaluation of maxillofacial AVM.

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“…The use of contrast medium in ultrasonography has already been used for diagnosis and monitoring of some vascular pathologies such as extracranial carotid atheromatous pathology, aortic pathologies, and peripheral arteriopathies. 17,18 Different studies have demonstrated diagnostic superiority of CEUS compared to conventional ultrasound in the identification of parietal vascular irregularities with associated measurement of their neo-vascularization to assess the vulnerability of atheromatous plaques. 19…”

Section: Discussionmentioning

confidence: 99%

CEUS-guided PTA on stenotic AVF: Morphological and functional point of view

2022

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Background: Stenosis represents the main cause of hemodialysis fistula malfunction. The ultrasound-guided angioplasty with ecographic contrast (CEUS) could provide further advantages to the classical ultrasound guided method improving the morphological characterization of the stenosis and providing quantitative data with the creation of time intensity curves (TIC) collecting functional data comparable between pre and post procedure. Methods: A total of 10 CEUS-guided angioplasties were performed on malfunctioning fistulas. The sonographic contrast medium was injected into the vascular tree trough the introducer. Morphological and functional data nature were collected. Were generated TIC curves, obtained by positioning a ROI in correspondence with the post-stenotic tract of the efferent vein. The data collected, regarding the peak intensity reached by the signal (PI) and the time to reach the peak signal intensity (TTP), were compared in the pre and post-procedural phase with flow of vascular access (Qa) and resistance indices (RI). Results: Statistically significant correlation ( p < 0.05) was observed between Qa and TTP ( r = 0.77; p = 0.009), RI and TTP ( r = 0.71; p = 0.02), Qa and PI ( r = 0.86; p = 0.0012), and between RI and PI ( r = 0.88; p < 0.001). Conclusion: In addition to the advantages associated with the use of ultrasound contrast medium in improving the visualization and characterization of the stenosis by facilitating the PTA procedure, the functional data deriving from the quantitative analysis provide new parameters for evaluating the success of the procedure which could also be used as predictive markers of stenosis recurrence together with the classical ones.

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The Role of Contrast-Enhanced Ultrasound in Managing Vascular Pathologies

Cited by 3 publications

References 44 publications

Diagnosis of Atherosclerotic Plaques Using Vascular Endothelial Growth Factor Receptor-2 Targeting Antibody Nano-microbubble as Ultrasound Contrast Agent

Diagnosis of Atherosclerotic Plaques Using Vascular Endothelial Growth Factor Receptor-2 Targeting Antibody Nano-microbubble as Ultrasound Contrast Agent

Contrast-Enhanced Ultrasound in the Detection and Evaluation of Maxillofacial Arteriovenous Malformation: A Case Report

CEUS-guided PTA on stenotic AVF: Morphological and functional point of view

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