Private sector engagement is crucial for the success of health programs, as it brings in additional resources, expertise, and innovation. The main objective of this review is to understand private sector engagement in healthcare delivery. A descriptive case study design using an analytical framework was used. Literature from well-researched articles were examined. Findings demonstrated an in-depth understanding of the challenges faced by healthcare delivery in developing countries, types, contextual factors, challenges, and solutions of private sector engagement were the key elements that influenced the delivery of healthcare services, especially during the COVID-19 pandemic. The main contribution of this work is to provide information on private sector engagement and identify gaps that require further inquiry to enhance health systems through strengthened public-private engagements. This information from the study is important to policymakers, private sector actors, researchers, and decision makers to enhance private sector engagement for the sustainability of health programs.