The role of context conditioning in the reinstatement of responding to an alcohol-predictive conditioned stimulus

LeCocq, Mandy Rita; Sun, Sophie; Chaudhri, Nadia

doi:10.1016/j.bbr.2021.113686

Cited by 5 publications

(1 citation statement)

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“…This results in reward-and extinction-related memories that can be variably recalled (N. Sun et al, 2011). A variety of influences can reinstate extinguished craving leading to relapse, including addiction-associated cues, contexts, and companions (de Wit & Stewart, 1981;LeCocq et al, 2022;Meng et al, 2021) ("people, places, and things").…”

Section: Possible Roles For Rgs14 In Addictionmentioning

confidence: 99%

RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

2022

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RGS14 is a multifunctional scaffolding protein that is highly expressed within postsynaptic spines of pyramidal neurons in hippocampal area CA2. Known roles of RGS14 in CA2 include regulating G protein, H‐Ras/ERK, and calcium signaling pathways to serve as a natural suppressor of synaptic plasticity and postsynaptic signaling. RGS14 also shows marked postsynaptic expression in major structures of the limbic system and basal ganglia, including the amygdala and both the ventral and dorsal subdivisions of the striatum. In this review, we discuss the signaling functions of RGS14 and its role in postsynaptic strength (long‐term potentiation) and spine structural plasticity in CA2 hippocampal neurons, and how RGS14 suppression of plasticity impacts linked behaviors such as spatial learning, object memory, and fear conditioning. We also review RGS14 expression in the limbic system and basal ganglia and speculate on its possible roles in regulating plasticity in these regions, with a focus on behaviors related to emotion and motivation. Finally, we explore the functional implications of RGS14 in various brain circuits and speculate on its possible roles in certain disease states such as hippocampal seizures, addiction, and anxiety disorders.

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