The Role of Confocal<scp>R</scp>aman Spectroscopy in Food Science

Pudney, Paul D. A.; Hancewicz, Thomas M.

doi:10.1002/0470027320.s8939

Cited by 6 publications

(6 citation statements)

References 82 publications

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“…The whole set‐up has been described previously in detail (Bongaerts and others 2008). The use of Confocal Raman spectroscopy in foods is now well established (Pudney and Hancewicz 2010). It has been used to measure concentrations within a food microstructure on the micron length scale (Pudney and others 2003; Pudney and others 2004).…”

Section: Methodsmentioning

confidence: 99%

High Pressure Homogenization Increases the In Vitro Bioaccessibility of α‐ and β‐Carotene in Carrot Emulsions But Not of Lycopene in Tomato Emulsions

Svelander¹,

López-Sánchez²,

Pudney³

et al. 2011

Journal of Food Science

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Section: Methodsmentioning

confidence: 99%

High Pressure Homogenization Increases the In Vitro Bioaccessibility of α‐ and β‐Carotene in Carrot Emulsions But Not of Lycopene in Tomato Emulsions

Svelander¹,

López-Sánchez²,

Pudney³

et al. 2011

Journal of Food Science

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“…However, there are methods for doing this, which generally come under the title of self-modeling curve resolution (SMCR) or multivariate curve resolution (MCR). 22…”

Section: Introductionmentioning

confidence: 99%

Confocal Raman Spectroscopy of Whole Hairs

et al. 2013

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This paper describes the application of Raman spectroscopy to whole hair fibers. Previously this has proved difficult because the hairs are relatively opaque, and spatial resolution diminishes with depth because of the change in refractive index. A solution is to couple confocal Raman with multivariate curve resolution (MCR) data analysis, which separates spectral differences with depth despite this reduction in resolution. Initially, it is shown that the cuticle can be separated from the cortex, showing the differences in the proteins, which can then be plotted as a function of depth, with the cuticle factor being seen only at the surface as expected. Hairs that had been treated in different ways, e.g., by bleaching, treatment with the active molecule resorcinol followed by rinsing and treatment with a full hair care product, were also examined. In all cases, changes to the hair are identified and are associated with specific parts of the fiber. Since the hair fiber is kept intact, it can be repeatedly treated and measured, hence multistep treatment processes can be followed. This method expands the potential use of Raman spectroscopy in hair research.

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“…The algorithms have now become more sophisticated after their original application to Raman mapping data by Andrew and Hancewicz [32] , and the one used here, called modified alternating least squares, is described by Wang et al [19] . This general area of data analysis applied to Raman applications has recently been reviewed [33] .…”

Section: Discussionmentioning

confidence: 99%

Measuring the Penetration of a Skin Sensitizer and Its Delivery Vehicles Simultaneously with Confocal Raman Spectroscopy

Bonnist

Gorce

MacKay

et al. 2011

Skin Pharmacol Physiol

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Among the factors determining the propensity of a chemical to induce skin allergy are the penetration into skin and the kinetics of ingress. Confocal Raman spectroscopy can provide such information as it enables direct, spatially resolved measurement of the skin and of any chemical uptake. Several chemicals can be monitored at once, and the method is non-destructive (light in, light out) so that the skin can be kept intact for repeated and continuous measurement. Raman spectroscopy was used to follow the penetration of 2.5 weight percent trans-cinnamaldehyde and its delivery vehicle into skin in vitro, up to 24 h after topical application. A custom-made Bronaugh-type diffusion cell that was suitable for the Raman experiment was used. Four different vehicles were tested: absolute ethanol, 50% aqueous ethanol, propylene glycol and acetone:olive oil (4:1); these gave different time scales for cinnamaldehyde penetration. The acetone:olive oil vehicle phase-separated on the skin surface and the cinnamaldehyde penetrated at different rates in the different phases, which may be of significance since this is the preferred solvent for the local lymph node assay (an in vivo animal test used to generate hazard information on skin sensitization). In conclusion, the Raman method gives valuable detailed information on chemical ingress, clearly differentiates between different delivery rates and allows solvent monitoring alongside the chemical of interest.

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The Role of ConfocalRaman Spectroscopy in Food Science

Cited by 6 publications

References 82 publications

High Pressure Homogenization Increases the In Vitro Bioaccessibility of α‐ and β‐Carotene in Carrot Emulsions But Not of Lycopene in Tomato Emulsions

High Pressure Homogenization Increases the In Vitro Bioaccessibility of α‐ and β‐Carotene in Carrot Emulsions But Not of Lycopene in Tomato Emulsions

Confocal Raman Spectroscopy of Whole Hairs

Measuring the Penetration of a Skin Sensitizer and Its Delivery Vehicles Simultaneously with Confocal Raman Spectroscopy

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