The role of competitive binding to human serum albumin on efavirenz–warfarin interaction: a nuclear magnetic resonance study

Three-dimensional (3D) structure prediction of the American and African oil-palms β-ketoacyl-[ACP] synthase-II protein by comparative modelling

“…We strongly believe that the 3D structures predicted for KASII proteins should be closer to real structures of these respective proteins. However, we suggest the further wet lab experimental work to validate these predicted structures using X-ray crystallography or NMR technique [9, 10]. Similarly, the active-site residues of KASII proteins has been determined successfully but have not been tested experimentally.…”

“…This warrants the study on oil palms KASII protein structures. Protein structures can be studied using X-ray crystallography and or NMR techniques [9, 10]. However, protein structures can be predicted using computational tools to quickly understand the protein structure [11].…”

Interactions Between Sirolimus and Anti-Inflammatory Drugs: Competitive Binding for Human Serum Albumin

“…However competition ability of drugs depends on their binding affinities, relative concentration, and specificity of binding. [8][9][10] Sirolimus (SRL, formerly Rapamycin: C 51 H 79 NO 13 , CAS: 53123-88-9) is a lactone-lactam macrolide antibiotic that joined the immunosuppressant depot when it was approved by the Food and Drug Administration (FDA) for the prevention of kidney transplant rejection ( Figure 1). 8,11 Sirolimus is metabolized by CYP3A4 in human liver.…”

“…[8][9][10] Sirolimus (SRL, formerly Rapamycin: C 51 H 79 NO 13 , CAS: 53123-88-9) is a lactone-lactam macrolide antibiotic that joined the immunosuppressant depot when it was approved by the Food and Drug Administration (FDA) for the prevention of kidney transplant rejection ( Figure 1). 8,11 Sirolimus is metabolized by CYP3A4 in human liver. 12,13 The structure of this drug is related to tacrolimus but the mechanism of action of these drugs is different.…”

Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltration technique for the determination of plasma protein binding of three coumarins using acetone as protein binding releasing agent

“…The reasons lending to this phenomenon are complex while one of which may be the effect of protein binding rate. It is well known that when two or more drugs are administrated in combination, the competition for the protein among them may occur [35,36]. While, the change of protein binding can alter the unbound drug concentrations which is responsible for drug efficacy and potential drug toxicity.…”