The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease

Abstract

BackgroundThe cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.MethodsThe DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP.ResultsThere is no significant difference in CETP allele frequency or genotype distribution among LMCAD and MPCAD patients although there is statistical difference between LMCAD and Controls (p = 0.001). Specifically, patients with LMCAD and B1B1 genotype of TaqIB polymorphism were more frequent present compared to Controls (33.8% vs 22.9%, respectively). The frequency of B2B2 genotype was 3 times lower in the LMCAD group compared to Controls (10.5% vs 30.2%, respectively). In the LMCAD group the frequency of B1 allele compared to Controls was higher (62% vs 46%, respectively, p = 0.001). The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A.ConclusionsThese findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. However, this polymorphism cannot distinguish between LMCAD and MPCAD. Further prospective investigations in larger populations are required to confirm these findings.

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

“…It is currently believed that CHD is caused by multiple genetic factors combined with environmental factors (Tsujita et al, 2007;Kimura, 2009), and that lipid metabolism disorder can lead to the occurrence of CHD (Kolovou et al, 2011). The present study demonstrated that the plasma levels of TC, LDL-C, and lipoprotein(a) were significantly higher in the ACS and stable CHD groups compared to the control group.…”

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

“…The study selection process is detailed in Figure 1 . Through a comprehensive retrieval and evaluation, 45 studies from 44 papers with 20,866 cases and 21,298 controls met the inclusion criteria to assess the association between the CETP TaqIB polymorphism and the composite ischemic CVD [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The selected study characteristics and data are listed in Table 1 .…”

Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

“…In consideration of the study design, 6 studies were prospective [ 20 , 40 , 43 , 45 , 49 ] and the remaining 41 studies were retrospective [ 11 , 17 , 21 , 22 , 36 - 38 , 41 , 42 , 44 , 46 - 48 , 50 - 67 ]. In addition,11 of the 47 studies were P-B [ 20 - 22 , 36 , 37 , 40 , 43 , 46 , 49 , 54 ] and the remaining studies were H-B [ 11 , 17 , 38 , 39 , 41 , 42 , 44 , 45 , 47 , 48 , 50 - 53 , 55 - 66 ]. CAD was regarded as the main outcome in most of the studies [ 11 , 17 , 21 , 22 , 36 - 40 , 42 , 44 , 45 , 47 , 49 - 51 , 53 , 55 - 61 , 64 - 66 ], except 8 studies analyzed MI [ 20 , 43 , 46 , 48 , 52 , 54 , 62 , 63 ] and 2 studies analyzed ACS [ …”

“…In addition,11 of the 47 studies were P-B [ 20 - 22 , 36 , 37 , 40 , 43 , 46 , 49 , 54 ] and the remaining studies were H-B [ 11 , 17 , 38 , 39 , 41 , 42 , 44 , 45 , 47 , 48 , 50 - 53 , 55 - 66 ]. CAD was regarded as the main outcome in most of the studies [ 11 , 17 , 21 , 22 , 36 - 40 , 42 , 44 , 45 , 47 , 49 - 51 , 53 , 55 - 61 , 64 - 66 ], except 8 studies analyzed MI [ 20 , 43 , 46 , 48 , 52 , 54 , 62 , 63 ] and 2 studies analyzed ACS [ 41 ] as the endpoint. A significant departure from HWE was found in 7 studies [ 21 , 39 , 48 , 52 , 63 ].…”