The role of combined use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis in pediatric intensive care unit

Altıntop, Yasemin Ay; Ergül, Ayşe Betül; Koç, Ayşe; Atalay, Mustafa

doi:10.5455/medscience.2021.04.134

Cited by 3 publications

(2 citation statements)

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“…Due to the common use of fluconazole in empiric antifungal prophylaxis in high-risk premature infants, an increased colonization of the gastrointestinal tract with Candida non-albicans was observed. The main pathogens were Candida parapsilosis (increase in all the studied years except 2017) and Candida glabrata in 2019 and 2020, which is in accordance with data published in the literature [8][9][10][11][12][13].…”

Section: Discussionsupporting

confidence: 89%

Fungal Infection Testing in Pediatric Intensive Care Units—A Single Center Experience

Klepacka

Zakrzewska

Czogała

et al. 2022

IJERPH

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Mycoses are diseases caused by fungi that involve different parts of the body and can generate dangerous treatment complications. This study aims to analyze fungal infection epidemiology in intensive care units (Pediatric and Cardiac Surgery Intensive Care Units—PCICU) and the Neonatal Intensive Care Unit (NICU) in one large pediatric center in the period 2015–2020 compared with 2005. The year 2005 was randomly selected as a historical time reference to notice possible changes. In 2005 and 2015–2020, 23,334 mycological tests were performed in intensive care units. A total of 4628 tests (19.8%) were performed in the intensive care units. Microbiological diagnostics involved mycological and serological testing. Of the 458 children hospitalized in the NICU, positive results in the mycological tests in the studied years were found in 21–27% of the children and out of 1056 PCICU patients, positive results were noticed in 18–29%. In both departments, the main detected pathogen was Candida albicans which is comparable with data published in other centers. Our experience indicates that blood cultures as well as the detection of antifungal antibodies do not add important information to mycological diagnostics. For the years of observation, only a few positive results were detected, even in patients with invasive fungal diseases. To our knowledge, this is one of a few similar studies over recent years and it provides contemporary reports of mycoses in pediatric ICU patients.

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Section: Discussionsupporting

confidence: 89%

Fungal Infection Testing in Pediatric Intensive Care Units—A Single Center Experience

Klepacka

Zakrzewska

Czogała

et al. 2022

IJERPH

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“…Similar findings were made by Mokaddas, et al, who discovered that when the Ag threshold was set at 500, there was no discernible rise in the diagnosis of individuals with mucosal Candida colonisation in their Ag levels [35]. Children in the ICU who potentially develop IC were studied in a study by Rao et al, and it was discovered that Ag was 100% sensitive [36].…”

Section: Discussionsupporting

confidence: 59%

Candidemia: A Hospital Based Study in Haematological Patients in Adult Population of Northern India

banerjee¹

2023

JCIM

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Background: Candidemia has become a common cause of fungal infection in bloodstream infection throughout the world. In hematological malignancies, patients have high rate of morbidity and mortality due to Candidemia. Objective: Early diagnosis and specific identification of Candida species in hematological patients is main purpose of the proposed study. Methods: In present study we enrolled patients with hematological malignancies (duration November 2018- April 2022). For early diagnosis of Candidemia we did conventional method, antigen detection and PCR. We compared the conventional, automated, antigen detection test and PCR method for diagnosis of Candidemia and then we performed antifungal susceptibility testing for treatment in hematological patients. Results: Total 229 patients were enrolled on the basis of febrile neutropenia. Total 152/229 male (66.37%) and 77/229 (33.62%) were participated in present study followed by age range from 10- 77 years (Mean=33.65, Standard deviation=16.40). Prevalence of the Candidemia was 2.1 in the present study. Five patients (2.6%) were positive from blood culture and nine patients (4.8%) were positive by PCR. Among 4 patients of AML, there were 3 Candida troicalis (3; 1.60%) and 1 Candida auris (1; 0.5%) were present followed by 1 patient of pancytopenia Candida tropicalis (1; 0.5%) present. Conclusion: This present observational study recognizes main association of Candidemia in hematological malignancies. Automated methods are more sensitive and specific for species identification. We try to apply Non culture method like PCR and mannan antigen in routine laboratories to diagnose early stage Candidemia infection for better treatment to cure the disease.

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Actualización en el diagnóstico de la endocarditis fúngica pediátrica y sus limitaciones en Latinoamérica

Solé Morales,

Hernández Quiroa,

Sajmolo Ruiz

2024

Revista Latinoamericana De Infectología Pediátrica

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The role of combined use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis in pediatric intensive care unit

Cited by 3 publications

References 0 publications

Fungal Infection Testing in Pediatric Intensive Care Units—A Single Center Experience

Fungal Infection Testing in Pediatric Intensive Care Units—A Single Center Experience

Candidemia: A Hospital Based Study in Haematological Patients in Adult Population of Northern India

Actualización en el diagnóstico de la endocarditis fúngica pediátrica y sus limitaciones en Latinoamérica

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