The Role of Combination of 20% Azelaic Acid with 0.05% Tretinoin Cream in the Treatment of Melasma

Hazra, SC; Siddique,; Khondker, Lubna; Khan, Msi; Mahmud, MM

doi:10.3329/bmj.v40i2.18501

Cited by 1 publication

(1 citation statement)

References 12 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total 64% patients were married. This finding is consistent with study conducted by Hazra et al 16 . Melasma most commonly seen in married women may be due to use of oral contraceptives and in few patients it started during pregnancy that may persist thereafter.…”

Section: Discussionsupporting

confidence: 94%

Study of Efficacy and Safety of Triple Combination Agent (4% Hydroquinone, 0.05% Tretinoin and 0.05% Clobetasone Butyrate) in the Treatment of Melasma

Khan¹,

Ahamed

2013

Faridpur Med Coll J

View full text Add to dashboard Cite

Melasma is a very common disorder of hypermelanosis affecting face. The pigmented patches usually affect darker complexioned individual especially Asian. An interventional study was carried out to detect the efficacy and safety of triple combination agent (4% Hydroquinone, 0.05% Tretinoin and 0.05% Clobetasone butyrate) in the treatment of melasma. Total 50 clinically diagnosed cases of melasma attending in outpatient department of Dermatology and Venereology, Diabetic Association Medical College Hospital (DAMCH), Faridpur were evaluated. Maximum patients (40%) were between 31-35 years of age and 80% were female. Sun exposure (60%) and contraceptive pill (36%) were common precipitating factors. Of them 54% patients have skin type IV, 24% patients have skin type III. Centrofacial melasma (64%) was the commonest pattern of melasma. MASI score at base line was 9.45, and after 12th week were 4.62. After completion of therapy there was remarkable reduction (51.11%) of severity of melasma. The triple combination agent were well tolerated and commonly observed side effects were erythema (34%) and burning (22%). This study demonstrates that every night application of triple combination agents has significant lightening effect in the treatment of melasma.a DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16893 Faridpur Med. Coll. J. 2013;8(1): 22-25

show abstract

Section: Discussionsupporting

confidence: 94%