The role of circulating tumor DNA in diagnosis and optimization of treatment of localized and local pancreatic cancer
A. V. Shabunin,
V. V. Ptushkin,
M. M. Tavobilov
et al.
Abstract:Pancreatic cancer (PC) is a malignant highly aggressive tumor that arises and grows under conditions of inflammation and tissue hypoxia. In PC, one of the key processes in progression is epithelial-mesenchymal transition, which leads to early dissemination and rapid realization of metastatic disease, which accounts for low overall survival rates. The tumor, by releasing a wide range of different molecules (circulating DNA, exosomes, proteins and lipids), allows to identify and use them as potential, diagnostic… Show more
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