The role of circulating tumor cells as a prognostic marker in the adjuvant setting of patients with breast cancer

Elmorshidy, S.M.; Fattah, Ola N. Abdel; Eissa, Hoda H; Sayed, Douaa; Mohamed, Samir S.

doi:10.4103/jcmrp.jcmrp_144_18

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…We found that although CTCs ≥ 5 were associated with the advanced stages of the disease, some patients with early stages showed the presence of CTCs ≥ 5 suggesting the early spread of the disease which was in accordance with Elmorshidy et al [ 26 ] who stated that the presence of CTCs in early stage disease implies that an advanced stage is not necessary for cancer cells to enter the circulation and spread.…”

Section: Discussionsupporting

confidence: 90%

“…These results are supported also by Karhade et al [ 29 ] who reported that CTCs predict shorter progression-free and overall survival in TNBC cases, and Gwark et al [ 30 ] who found that patients with TNBC who failed to achieve PCR with ≥5 CTCs showed worse RFS and OS. Furthermore, CTCs could be used as an independent predictive and prognostic biomarker for MBC patients' outcomes [ 21 ] and can predict early disease recurrence and reduce the OS in patient's nonmetastatic breast cancer [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Implications of MALAT1 and BACH1 Expression and Their Correlation with CTCs and Mo-MDSCs in Triple Negative Breast Cancer and Surgical Management Options

Elbasateeny

Yassin

Mokhtar

et al. 2022

International Journal of Breast Cancer

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Background. Triple negative breast cancer (TNBC) is a biologically separate entity of breast cancer that cannot get benefits from targeted or endocrine therapy. Objective. To assess the expression of MALAT1 and BACH1, as well as monocyte-myeloid-derived suppressor cell (Mo-MDSC) levels and circulating tumor cell (CTC) count in TNBC to correlate these markers with the clinic-pathological criteria of TNCB patients and to evaluate their roles as predictive markers for selection of the patients that can be operated by oncoplastic conserving breast surgery. Methods. Eighty-eight TNBC were managed by modified doughnut breast oncoplastic surgery in early stages and by modified radical mastectomy for patients with late stages unsuitable for breast-conserving. All were examined for MALAT1 and BACH1 expression by immunohistochemistry and RT-PCR as well as Mo-MDSC levels and CTCs. Results. MALAT1 and BACH1 expressions are correlated with the larger size, lymph node, distance metastasis, and TNM staging ( p < 0.05 ). CTCs ≥ 5 and high MO-MDSCs were significantly more in TNBC with MALAT1 and BACH1 overexpression. The survival study proved that DFS for patients with both positive expression of MALAT1 and BACH1 was shorter than that of one positive expression, and both negative expression p ≤ 0.001 , CTCs ≥ 5 , and high Mo-MDSCs are associated with poor outcomes. No significant difference between modified round block and modified radical mastectomy techniques as regards recurrence. However, all postoperative management outcomes were significantly better in patients operated by oncoplastic conserving breast surgery. Conclusion. BACH1 and MALAT1 expressions are significantly upregulated in TNBC. They are correlated with CTCs and Mo-MDCs, and all are associated with poor outcomes. Not all TNBC patients have a bad prognosis, patients negative for one of MALAT1 and BACH1 or both, have a slightly good prognosis, and so can be managed by breast oncoplastic conserving surgery.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Prognostic Implications of MALAT1 and BACH1 Expression and Their Correlation with CTCs and Mo-MDSCs in Triple Negative Breast Cancer and Surgical Management Options

Elbasateeny

Yassin

Mokhtar

et al. 2022

International Journal of Breast Cancer

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“…Elmorshidy et al . [ 14 ] evaluated the role of CTCs as a biomarker in patients with non-metastatic breast cancer by using flow cytometry. The authors concluded that the presence of more than or equal to 5 CTCs/7.5 mL at baseline would predict early disease recurrence and reduce overall survival in patients with non-metastatic breast cancer receiving adjunct chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Detection of Circulating Tumor Cells by Cell Block Technique in Malignant Tumors

Vijay,

Kumar,

Murthy

2023

Journal of Cytology

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Introduction: Cancer is a leading cause of death worldwide and is a major cause of morbidity. To deal with this magnitude of cancers and their diagnostic and prognostics, a multitude of prognostic biomarkers for various cancers have been explored over the decades, with detection of circulating tumor cells (CTCs) in the peripheral blood being one of them. This study was undertaken to explore the routine procedure of cell block in the cytopathology lab to isolate and detect CTCs. Materials and Methods: In this cross-sectional study, 112 peripheral blood samples sent for routine blood investigations of various cancer patients were utilized for the preparation of cell block. The sections from the cell block were stained routinely and evaluated for the presence of CTCs. The statistical analysis was done using Mac Statplus software version 8.0. Results: The malignancies were tabulated as per the International Classification of Diseases for Oncology, third edition (ICD-O-3). The maximum number of cases were from C 50 (breast) - 41/112 (36.6%), followed by C15–C26 (Digestive organs) - 19/112 (16.9%), and C00–C14 (lip, oral cavity, and pharynx) - 18/112 (16.07%) cases. CTC was detected in six (5.35%) out of 112 cases, out of which three were from the breast and one each from category C6.9 (mouth), C32.0 (glottis), and C53.8 (cervix uteri). Conclusion: Among various advanced and molecular techniques available for the detection of CTCs, the cell block technique proves to be one of the effective methods, especially in resource-limited settings as these can further be utilized for additional diagnostic techniques similar to the ones employed for routine paraffin blocks.

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The role of circulating tumor cells as a prognostic marker in the adjuvant setting of patients with breast cancer

Cited by 2 publications

References 2 publications

Prognostic Implications of MALAT1 and BACH1 Expression and Their Correlation with CTCs and Mo-MDSCs in Triple Negative Breast Cancer and Surgical Management Options

Prognostic Implications of MALAT1 and BACH1 Expression and Their Correlation with CTCs and Mo-MDSCs in Triple Negative Breast Cancer and Surgical Management Options

Detection of Circulating Tumor Cells by Cell Block Technique in Malignant Tumors

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