The role of CircRNA/miRNA/mRNA axis in breast cancer drug resistance

Ghazimoradi, Mohammad Hossein; Babashah, Sadegh

doi:10.3389/fonc.2022.966083

Cited by 19 publications

(12 citation statements)

References 72 publications

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“…In addition to the pathogenic changes brought on by alterations in the ceRNA networks, the effects on response and resistance to anticancer drugs have also been observed. CircRNA/miRNA/mRNA interactions have been implicated in resistance to paclitaxel (PAX), such as CircGFRA1/miR-361-5p/TLR4, Circ-0006528/miR-1299/CDK8, and Circ-ABCB10/let7a-5p/DUSP7, and 5-fluorouracil, such as CDR1as/miR-7/CCNE1 and CircFBXL5/miR-216b/HMGA2, as well as doxorubicin and tamoxifen, such as CircBMPR2/miR-553/USP4, hsa_circ_0025202/mir-182-5p/FOXO3, and miR-197-3p/HIPK3, and in various cancers, including breast cancer and TNBC [ 92 ]. Moreover, the lncRNA FTH1P3 promotes paclitaxel resistance in TNBC cells through a miR-206/ABCB1 axis [ 2 , 93 ].…”

Section: Significance Of Cernets Alterations In Tnbcmentioning

confidence: 99%

Genomic Alterations Affecting Competitive Endogenous RNAs (ceRNAs) and Regulatory Networks (ceRNETs) with Clinical Implications in Triple-Negative Breast Cancer (TNBC)

Qattan

2024

IJMS

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The concept of competitive endogenous RNA regulation has brought on a change in the way we think about transcriptional regulation by miRNA–mRNA interactions. Rather than the relatively simple idea of miRNAs negatively regulating mRNA transcripts, mRNAs and other non-coding RNAs can regulate miRNAs and, therefore, broad networks of gene products through competitive interactions. While this concept is not new, its significant roles in and implications on cancer have just recently come to light. The field is now ripe for the extrapolation of technologies with a substantial clinical impact on cancer. With the majority of the genome consisting of non-coding regions encoding regulatory RNAs, genomic alterations in cancer have considerable effects on these networks that have been previously unappreciated. Triple-negative breast cancer (TNBC) is characterized by high mutational burden, genomic instability and heterogeneity, making this aggressive breast cancer subtype particularly relevant to these changes. In the past few years, much has been learned about the roles of competitive endogenous RNA network regulation in tumorigenesis, disease progression and drug response in triple-negative breast cancer. In this review, we present a comprehensive view of the new knowledge and future perspectives on competitive endogenous RNA networks affected by genomic alterations in triple-negative breast cancer. An overview of the competitive endogenous RNA (ceRNA) hypothesis and its bearing on cellular function and disease is provided, followed by a thorough review of the literature surrounding key competitive endogenous RNAs in triple-negative breast cancer, the genomic alterations affecting them, key disease-relevant molecular and functional pathways regulated by them and the clinical implications and significance of their dysregulation. New knowledge of the roles of these regulatory mechanisms and the current acceleration of research in the field promises to generate insights into the diagnosis, classification and treatment of triple-negative breast cancer through the elucidation of new molecular mechanisms, therapeutic targets and biomarkers.

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Section: Significance Of Cernets Alterations In Tnbcmentioning

confidence: 99%

Genomic Alterations Affecting Competitive Endogenous RNAs (ceRNAs) and Regulatory Networks (ceRNETs) with Clinical Implications in Triple-Negative Breast Cancer (TNBC)

Qattan

2024

IJMS

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“…CircRNAs, which have a highly stable thermodynamic structure, act on and modulate pro-or anti-apoptotic proteins has been stated. They regulate the apoptosis of drug-resistant cancer cells via these pathways emphasized [36]. For example, circAMOTL1 was seen to regulate the expression of AKT-related pro-apoptotic BAX and BAK and anti-apoptotic BCL-2 proteins in BC.…”

Section: Inhibition Of Cell Apoptosismentioning

confidence: 99%

circRNAs in drug resistance of breast cancer

Mısır¹,

YAMAN²,

PETROVIĆ³

et al. 2022

Oncology Research

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Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards for BC treatment. One of the significant challenges during the treatment of BC represents resistance to chemotherapeutics, resistance that severely limits the use and effectiveness of the drugs used for BC treatment.Therefore, it is essential to develop new strategies to improve therapeutic efficacy. Circular RNAs (circRNAs) are a large group of non-coding RNAs that covalently form closed circular loops by joining their 5′, and 3′; ends.Accumulating evidence suggests that circRNAs have a vital role in cancer development, progression, and BC resistance to chemotherapy. The purpose of this review is to discuss the biological properties of circRNAs, and how circRNAs induce resistance to conventional therapeutic anti-cancer drugs used in BC treatment, by emphasizing and summarizing the potential roles of circRNAs in mechanisms of drug resistance, such as drug efflux, apoptosis dysfunction, autophagy, and DNA damage repair. CircRNAs are associated with drug resistance via ATP-binding cassette (ABC) efflux transporters, while some others by inhibition of cell apoptosis, thus leading to resistance to tamoxifen in BC cells. In contrast, others are involved in the promotion of BC cells chemoresistance by doxorubicininduced autophagy. CircRNAs may have clinical significance in regulating or overcoming BC drug resistance and may give directions towards a novel approach to personalized BC treatment. CircRNAs may significantly contribute to the identification of new therapeutic targets for the prevention of BC chemoresistance.

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“…molecules have recently been found to attach to miRNAs as sponges, suppressing miRNA function. 19,20 miRNAs are a family of endogenously generated ncRNAs, approximately 22 nucleotides in length. They play regulatory roles in gene expression by binding to partially complementary target sequences in specific mRNAs, leading to their degradation and/or translational repression.…”

Section: Introductionmentioning

confidence: 99%

“…Despite being discovered in RNA viroids in the 1970s, circRNAs were overlooked in the past because they were considered byproducts of splicing events. These RNA molecules have recently been found to attach to miRNAs as sponges, suppressing miRNA function 19,20 …”

Section: Introductionmentioning

confidence: 99%

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Competitive endogenous RNA networks: Decoding the role of long non‐coding RNAs and circular RNAs in colorectal cancer chemoresistance

Khalafizadeh,

Hashemizadegan,

Shokri

et al. 2024

J Cellular Molecular Medi

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Colorectal cancer (CRC) is recognized as one of the most common gastrointestinal malignancies across the globe. Despite significant progress in designing novel treatments for CRC, there is a pressing need for more effective therapeutic approaches. Unfortunately, many patients undergoing chemotherapy develop drug resistance, posing a significant challenge for cancer treatment. Non‐coding RNAs (ncRNAs) have been found to play crucial roles in CRC development and its response to chemotherapy. However, there are still gaps in our understanding of interactions among various ncRNAs, such as long non‐coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs). These ncRNAs can act as either oncogenes or tumour suppressors, affecting numerous biological functions in different cancers including CRC. A class of ncRNA molecules known as competitive endogenous RNAs (ceRNAs) has emerged as a key player in various cellular processes. These molecules form networks through lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions. In CRC, dysregulation of ceRNA networks has been observed across various cellular processes, including proliferation, apoptosis and angiogenesis. These dysregulations are believed to play a significant role in the progression of CRC and, in certain instances, may contribute to the development of chemoresistance. Enriching our knowledge of these dysregulations holds promise for advancing the field of diagnostic and therapeutic modalities for CRC. In this review, we discuss lncRNA‐ and circRNA‐associated ceRNA networks implicated in the emergence and advancement of drug resistance in colorectal carcinogenesis.

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The role of CircRNA/miRNA/mRNA axis in breast cancer drug resistance

Cited by 19 publications

References 72 publications

Genomic Alterations Affecting Competitive Endogenous RNAs (ceRNAs) and Regulatory Networks (ceRNETs) with Clinical Implications in Triple-Negative Breast Cancer (TNBC)

Genomic Alterations Affecting Competitive Endogenous RNAs (ceRNAs) and Regulatory Networks (ceRNETs) with Clinical Implications in Triple-Negative Breast Cancer (TNBC)

circRNAs in drug resistance of breast cancer

Competitive endogenous RNA networks: Decoding the role of long non‐coding RNAs and circular RNAs in colorectal cancer chemoresistance

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