The role of cholesterol metabolism in leukemia

Zhao, Liang; Zhan, Huien; Xinya, Jiang; Li, Yangqiu; Zeng, Hui

doi:10.1097/bs9.0000000000000016

Cited by 15 publications

(16 citation statements)

References 79 publications

(91 reference statements)

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“…U-937 cell proliferation following the treatment with PS was also monitored ( Supplementary Figure S13 ). This cell line was also very sensitive at lower dosages, and indeed, it is targeted by many different treatments, as many metabolic-related genes are involved in leukaemia [ 41 ]. MePR2B normal cells were used as the control cell line to prove anticancer specificity.…”

Section: Resultsmentioning

confidence: 99%

“…For successive assays on the selected cell lines, 24-MChol was used at increasing concentrations (0.3, 3 and 30 μM) and compared to β-SIT as the reference compound, which was previously tested on MCF7 cells [ 31 , 34 , 41 ]. The proliferation rates by the trypan blue exclusion method showed a strong decrease of cell proliferation in both the A549 and MCF7 cell lines in a dose-dependent manner following 24–48 h of treatment with no impact on MePR2B cells after 24 h, suggesting the presence of a therapeutic window for the cancer-specific activity of PS ( Figure 4 and Supplementary Figure S15 ).…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxic Potential of the Marine Diatom Thalassiosira rotula: Insights into Bioactivity of 24-Methylene Cholesterol

et al. 2022

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Marine microalgae are receiving great interest as sustainable sources of bioactive metabolites for health, nutrition and personal care. In the present study, a bioassay-guided screening allowed identifying an enriched fraction from SPE separation of the methanolic extract of the marine diatom Thalassiosira rotula with a chemically heterogeneous composition of cytotoxic molecules, including PUFAs, the terpene phytol, the carotenoid fucoxanthin and the phytosterol 24-methylene cholesterol (24-MChol). In particular, this latter was the object of deep investigation aimed to gain insight into the mechanisms of action activated in two tumour cell models recognised as resistant to chemical treatments, the breast MCF7 and the lung A549 cell lines. The results of our studies revealed that 24-MChol, in line with the most studied β-sitosterol (β-SIT), showed cytotoxic activity in a 3–30 µM range of concentration involving the induction of apoptosis and cell cycle arrest, although differences emerged between the two sterols and the two cancer systems when specific targets where investigated (caspase-3, caspase-9, FAS and TRAIL).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Cytotoxic Potential of the Marine Diatom Thalassiosira rotula: Insights into Bioactivity of 24-Methylene Cholesterol

et al. 2022

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“…Currently, the mechanisms underlying the association between hypocholesterolaemia and CLL development are not well understood. Dysregulation of cholesterol homeostasis has been suggested to participate in certain forms of carcinogenesis, especially in leukaemia cells, which display increased synthesis and uptake of cholesterol to satisfy their high turnover rate [ 34 ]. HDL-C is known to have a protective role against cancer through anti-inflammatory and anti-oxidative properties.…”

Section: Discussionmentioning

confidence: 99%

Low Serum Cholesterol Level Is a Significant Prognostic Factor That Improves CLL-IPI in Chronic Lymphocytic Leukaemia

Gao

Liang

et al. 2023

IJMS

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Hypocholesterolaemia is associated with elevated cancer risk and mortality, yet the relation between chronic lymphocytic leukaemia (CLL) and serum lipid profile remains unclear. Our study aims to evaluate the prognostic value of cholesterol levels in CLL and develop a prognostic nomogram that incorporates lipid metabolism. We enrolled 761 newly diagnosed CLL patients and separated them into either derivation (n = 507) or validation (n = 254) cohorts. The prognostic nomogram was constructed through multivariate Cox regression analyses, with performance evaluated using C-index, the area under the curve, calibration, and decision curve analyses. Decreased total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) at diagnosis were significantly associated with worse time to first treatment (TTFT) and cancer-specific survival (CSS), and simultaneously, low HDL-C with low LDL-C was identified as an independent prognostic indicator for both TTFT and CSS. CLL patients achieving complete or partial remission post-chemotherapy had significantly increased TC, HDL-C, and LDL-C levels compared with the baseline, and post-therapeutic HDL-C and LDL-C elevation correlated with favourable survival. The prognostic nomogram augmenting the CLL international prognostic index with low cholesterol levels yielded higher predictive accuracy and discrimination capacity for both 3-year and 5-year CSS. In conclusion, cholesterol profiles can be used as a cheap and readily accessible tool for predicting prognosis in CLL practice.

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“…Through search in articles, we found similar results were matched with our results 18,19 . Many surveys have been performed considering the serum lipids abnormalities 20 ; in table 2, no statistically significant variations in plasma total cholesterol, triglycerides, or high-density lipoprotein were detected between men and females, neither for AML patients nor controls. There was a considerable decrease(p˂0.05) in cholesterol and HDL, whereas triglycerides value a significantly elevated(P˂0.05) when compared with males between( patients and controls) and females between (patients and power).…”

Section: Discussionmentioning

confidence: 99%

Role of Vitamin D in the diagnosis of acute Myeloid Leukemia

Tahir

Thamer²,

Mahmood³

2023

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A range of hematological and biochemical markers have been investigated in Acute Myeloid Leukemia (AML) patients to determine the relationship between cancer growth and metabolic problems. This study aimed to determine the effects of vitamin D deficiency in Iraqi patients with acute myeloid leukemia who had recently been diagnosed. There was a significant inverse correlation between the total serum cholesterol (TC) level of acute myeloid leukemia (AML) patients group [(148.77±12.2) for males, (165.29±9.64) for females] and the control group [(164.50±7.26) for males, (180.05±7.31) for females], also an inverse correlation between high-density lipoprotein (HDL) level of acute myeloid leukemia (AML) patients group [(46.00±2.04) for males, (46.18±1.08) for females] and control group [(54.25±1.86) for males,(51.94±1.37) for females]. A significant difference was between the serum triglyceride (TG) level of acute myeloid leukemia (AML) patients group [(128.71±13.07) for males, (152.48±10.6) for females] and control group [85.12±11.30) for male, (90.50±10.90) for females], also between vitamin D level of acute myeloid leukemia (AML) patients group [(17.23±1.18) for males, (12.96±0.74) for females] and control group [(42.62±1.43) for males, (40.76±0.82) for females]. A statistically significant difference was between the serum calcium levels of individuals with acute myeloid leukemia [(8.99±0.32) for males, (8.91±0.23) for females] and the control group [(13.13±1.16) for males, (10.73±0.28) for females]. AML patients can benefit from vitamin D treatment, according to a pairwise analysis of receiver operating characteristic (ROC) curves. The above results are related to concluding that Vitamin D can be utilized as a diagnostic test for AML patients. Keywords; acute myeloid leukemia (AML), Hypereosinophilia, ROC curve, hypocholesterolemia, vitamin D.

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The role of cholesterol metabolism in leukemia

Cited by 15 publications

References 79 publications

Cytotoxic Potential of the Marine Diatom Thalassiosira rotula: Insights into Bioactivity of 24-Methylene Cholesterol

Cytotoxic Potential of the Marine Diatom Thalassiosira rotula: Insights into Bioactivity of 24-Methylene Cholesterol

Low Serum Cholesterol Level Is a Significant Prognostic Factor That Improves CLL-IPI in Chronic Lymphocytic Leukaemia

Role of Vitamin D in the diagnosis of acute Myeloid Leukemia

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