The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection

Souza, Patricia R.; Souza, Adriano Lopes de; Negrão-Corrêa, Déborah; Teixeira, Antônio Lúcio; Teixeira, Mauro Martins

doi:10.1016/j.actatropica.2008.04.016

Cited by 24 publications

(33 citation statements)

References 30 publications

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“…In this work, we observed high levels of MIP-1α, mainly in the CSF of patients with SMR as opposed to in patients with HAM. As stated above, some authors have noted that MIP-1α is an important factor in inducing the production of Th2 cytokines [41,42] which, along, with the recruitment of inflammatory cells such as eosinophils, suggests an important role of this chemokine in the pathogenesis of SMR [26]. As observed for MIP-1α, this study found higher levels of RANTES/CCL-5 in the CSF of patients with SMR than in the control groups.…”

Section: Discussionsupporting

confidence: 67%

“…Indeed, Souza et al [41,42] observed higher levels of MIP-1α in patients with severe forms of schistosomiasis, and it has been demonstrated that MIP-1α induces the production of Th2 cytokines, including IL-13 [43,44]. …”

Section: Discussionmentioning

confidence: 99%

“…In addition to the different patterns of cytokines, chemokines, small proteins involved in the normal traffic of leukocytes and their recruitment to sites of injury, have been recognized for contributing to the inflammatory response observed in the development of periportal fibrosis in schistosomiasis [41]. Indeed, Souza et al [41,42] observed higher levels of MIP-1α in patients with severe forms of schistosomiasis, and it has been demonstrated that MIP-1α induces the production of Th2 cytokines, including IL-13 [43,44].…”

Section: Discussionmentioning

confidence: 99%

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Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Kruschewsky

Cardoso²,

Fernandes³

et al. 2016

Neuroimmunomodulation

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Background: Schistosomal myeloradiculopathy (SMR) is the most serious ectopic presentation of Schistosoma mansoni infection. The pathogenesis occurs mainly via the host inflammatory response to the eggs of the parasite that are stuck in the central nervous system, and the diagnosis is generally made by the exclusion of other neurological diseases. Objective: We aimed to evaluate the immune status of SMR patients and to identify a marker for SMR diagnosis. Methods: We enrolled 15 patients with a presumptive diagnosis of SMR, and the control groups included 17 patients with myelopathy associated with human T cell lymphotropic virus type 1 (HTLV-1) and 11 with other neurological disorders. The determination of soluble egg antigen-specific IgE and the levels of cytokines from Th1, Th2, Th17 and T-regulatory cell profiles and the chemokines MIP-1a and RANTES were measured in the cerebrospinal fluid (CSF) and serum using an ELISA technique. Results: We observed that SMR leads to an increase in IgE levels in the CSF compared to serum, and the levels of IL-13 and MIP-1α were significantly higher in the CSF and serum of the SMR patients than in the patients with HTLV-1-associated myelopathy. The levels of MIP-1α and RANTES were higher in the CSF than in the serum of the SMR group. The ratio between levels of IL-13, MIP-1α and RANTES over IL-10 was positive in the CSF of the SMR patients. Conclusions: These results indicate that S. mansoni-specific IgE in the CSF is a promising marker for the diagnosis of SMR and that the cytokines and chemokines associated with the Th2 profile may be important factors in the immunopathogenesis of SMR.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Kruschewsky

Cardoso²,

Fernandes³

et al. 2016

Neuroimmunomodulation

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“…CCR5 is one of the receptors for CCL3, a chemokine previously shown to play an important role in the pathogenesis of human and murine schistosomiasis (16,41,42,43). Here, we demonstrate that in the absence of CCR5, S. mansoni infection is severely deleterious to the host, as shown by an increase in mortality rates and egg-associated liver pathology.…”

Section: Discussionmentioning

confidence: 70%

“…The activity of the N-acetylglucosaminidase (NAG) enzyme was used as an indirect measurement of macrophage infiltration in tissue samples, as previously shown (20), and the assay was performed after being adapted to small samples, as described elsewhere previously (3). Similarly, we used eosinophil peroxidase (EPO) activity to indirectly estimate the eosinophilic infiltration into the liver, as previously described (41,45).…”

Section: Animals and Infectionmentioning

confidence: 99%

Experimental Infection withSchistosoma mansoniin CCR5-Deficient Mice Is Associated with Increased Disease Severity, as CCR5 Plays a Role in Controlling Granulomatous Inflammation

Souza

Pereira

et al. 2011

Infect Immun

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The plasma level of the chemokine CCL3 is elevated in patients with chronic severe schistosomiasis mansoni. We have previously shown that CCL3؊/؊ mice with experimental infection showed diminished pathology and worm burden compared to those of wild-type (WT) mice. To elucidate further the role of CC chemokines during schistosomiasis mansoni infection, we evaluated the course of infection in C57BL/6J mice deficient in CCR5, one of the receptors for CCL3. The CCR5 deficiency proved to be remarkably deleterious to the host, since mortality rates reached 70% at 14 weeks postinfection in CCR5 ؊/؊ mice and 19% in WT mice. The increased lethality was not associated with an increased parasite burden, since similar numbers of eggs and adult worms were found in mice from both groups. Liver granulomas of chronically infected CCR5 ؊/؊ mice were larger and showed greater numbers of cells and collagen deposition than liver granulomas from WT mice. This was associated with higher levels of production of intereleukin-5 (IL-5), IL-13, CCL3, and CCL5 in infected CCR5 ؊/؊ mice than in infected WT mice. Moreover, at 8 weeks after infection, just before changes in pathology and mortality, the numbers of FoxP3-positive cells were lower in liver granulomas of CCR5 ؊/؊ mice than in WT mice. In conclusion, the CCR5 deletion is deleterious to mice infected with Schistosoma mansoni, and this is associated with enhanced fibrosis and granulomatous inflammation.

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Schistosomiasis-Associated Pulmonary Arterial Hypertension

Ferreira

Bandeira

Domingues

2015

Diagnosis and Management of Pulmonary Hypertension

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Schistosomiasis is the third most common endemic disease and has been considered the most common cause of pulmonary arterial hypertension (PAH) in the world. Around 6 % of people with chronic schistosomiasis in endemic areas are affected. Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) is classifi ed by the World Health Organization as group 1 pulmonary arterial hypertension because it has clinical, pathological, and hemodynamic characteristic that are similar to idiopathic pulmonary arterial hypertension. Sch-PAH is a severe disease that affects mainly middle-aged women. Symptoms and signs of right-heart insuffi ciency may be present, such as dyspnea, syncope, and peripheral edema. It has been demonstrated that Sch-PAH has a more benign clinical course and a better survival than idiopathic pulmonary hypertension. There are few reports of any benefi cial effect from specifi c therapy directed toward group 1 PAH in this population of patients. The mechanisms responsible for the development of pulmonary hypertension in patients with schistosomiasis are unknown. There is growing evidence that vessel obstruction and granulomatous reaction to pulmonary embolization of eggs is not the sole mechanism that causes the disease. Further studies are needed to better elucidate the pathogenesis of Sch-PAH and to develop targeted therapies for this devastating disease.

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The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection

Cited by 24 publications

References 30 publications

Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Experimental Infection withSchistosoma mansoniin CCR5-Deficient Mice Is Associated with Increased Disease Severity, as CCR5 Plays a Role in Controlling Granulomatous Inflammation

Schistosomiasis-Associated Pulmonary Arterial Hypertension

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