The Role of Chemokine IL-7 in Tumor and Its Potential Antitumor Immunity

Zhang, Leilei; Kewen, Zhou; Huang, Biao; Huang, Fang; Wang, Yigang

doi:10.1089/jir.2021.0236

Cited by 3 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oncolytic viruses (OVs) are specifically designed to target and destroy tumour cells, leaving healthy cells unharmed [ 104 ]. Not only can oncolytic viruses lyse cells directly, but the lysed tumour cells can also release tumour-associated antigens [ 4 ], as well as induce tumour immunity by releasing cytokines and exhibiting damage-associated molecular patterns to enhance antigen presentation and immune activation [ 105 ].…”

Section: Il-7 In Tumour Therapymentioning

confidence: 99%

“…IL-7 is mainly secreted by the bone marrow, thymus, and lymph nodes. Additionally, it is detected in sublymphatic organs such as the spleen, lymph nodes, and tonsils, as well as in non-lymphatic sites including the intestines, kidneys, lungs, skin, liver, brain, ovaries, and prostate [ 4 , 5 ]. This wide distribution indicates the significance of IL-7 in various physiological processes.…”

Section: Introductionmentioning

confidence: 99%

“…The IL-7 receptor (IL-7R) is a heterodimeric complex located on chromosome 5 [ 4 ]. It is 1380 bp long, containing eight exons and seven introns, and encodes 459 amino acids with a molecular weight of approximately 49.5 kDa [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advances in IL-7 Research on Tumour Therapy

Fu,

Zhang,

Zhang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Interleukin-7 (IL-7) is a versatile cytokine that plays a crucial role in regulating the immune system’s homeostasis. It is involved in the development, proliferation, and differentiation of B and T cells, as well as being essential for the differentiation and survival of naïve T cells and the production and maintenance of memory T cells. Given its potent biological functions, IL-7 is considered to have the potential to be widely used in the field of anti-tumour immunotherapy. Notably, IL-7 can improve the tumour microenvironment by promoting the development of Th17 cells, which can in turn promote the recruitment of effector T cells and NK cells. In addition, IL-7 can also down-regulate the expression of tumour growth factor-β and inhibit immunosuppression to promote anti-tumour efficacy, suggesting potential clinical applications for anti-tumour immunotherapy. This review aims to discuss the origin of IL-7 and its receptor IL-7R, its anti-tumour mechanism, and the recent advances in the application of IL-7 in tumour therapy.

show abstract

Section: Il-7 In Tumour Therapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Advances in IL-7 Research on Tumour Therapy

Fu,

Zhang,

Zhang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation

Robitaille,

Guertin,

Jamshidi

et al. 2024

Commun Med

View full text Add to dashboard Cite

Background High prostate eicosapentaenoic fatty acid (EPA) levels were associated with a significant reduction of upgrading to grade group (GG) ≥ 2 prostate cancer in men under active surveillance. We aimed to evaluate the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation. Methods A phase II double-blind randomized placebo-controlled trial was conducted in 130 men diagnosed with GG ≥ 2 prostate cancer and undergoing radical prostatectomy between 2015–2017 (Clinicaltrials.gov: NCT02333435). Participants were randomized to receive 3 g daily of either MAG-EPA (n = 65) or placebo (n = 65) for 7 weeks (range 4–10) prior to radical prostatectomy. The primary outcome was the cancer proliferation index quantified by automated image analysis of tumor nuclear Ki-67 expression using standardized prostatectomy tissue microarrays. Additional planned outcomes at surgery are reported including plasma levels of 27 inflammatory cytokines and fatty acid profiles in circulating red blood cells membranes and prostate tissue. Results Cancer proliferation index measured by Ki-67 expression was not statistically different between the intervention (3.10%) and placebo (2.85%) groups (p = 0.64). In the per protocol analyses, the adjusted estimated effect of MAG-EPA was greater but remained non-significant. Secondary outcome was the changes in plasma levels of 27 cytokines, of which only IL-7 was higher in MAG-EPA group compared to placebo (p = 0.026). Men randomized to MAG-EPA prior to surgery had four-fold higher EPA levels in prostate tissue compared to those on placebo. Conclusions This MAG-EPA intervention did not affect the primary outcome of prostate cancer proliferation according to nuclear Ki-67 expression. More studies are needed to decipher the effects of long-chain omega-3 fatty acid dietary supplementation in men with prostate cancer.

show abstract

Mendelian randomization investigation of the causal association between circulating cytokines and colorectal cancer

Yang

Zhang

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective To explore the causal relationship between colorectal cancer risk and circulating cytokines and identify potential predictive biomarkers. Methods This study employed a bidirectional Mendelian randomization (MR) analysis based on data from genome-wide association (GWAS) studies of colorectal cancer from people of European ancestry. The genetic variants associated with 41 circulating cytokines exposed were selected as instrumental variables for this experiment. For robustness and consistency of findings, we conducted additional sensitivity analyses and reverse Mendelian randomization assessments. Results The analysis revealed a strong causal relationship between colorectal cancer occurrence and Vascular Endothelial Growth Factor (VEGF), Macrophage Colony Stimulating Factor (MCSF), Interleukin-12p70 (IL-12p70), Interleukin-13(IL-13), Interleukin-10 levels (IL-10) and Interleukin-7 levels (IL-7) and demonstrated partial consistency. Sensitivity analyses indicated that IL-12p70, IL-7 and VEGF are potential colorectal cancer predictive biomarkers. Conclusion This Mendelian randomized study offers valuable insights into the causal relationships between specific circulating cytokines and colorectal cancer risk. The identified cytokines may serve as predictive biomarkers, enabling the development of novel diagnostic, preventive, and therapeutic approaches, but further experimental validation of their potential as diagnostic biomarkers or cancer-related pharmacological targets is necessary.

show abstract

The Role of Chemokine IL-7 in Tumor and Its Potential Antitumor Immunity

Cited by 3 publications

References 54 publications

Advances in IL-7 Research on Tumour Therapy

Advances in IL-7 Research on Tumour Therapy

A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation

Mendelian randomization investigation of the causal association between circulating cytokines and colorectal cancer

Contact Info

Product

Resources

About