The role of chemokine and chemokine receptor gene variants on the susceptibility and clinicopathological characteristics of bladder cancer

Küçükgergin, Canan; İşman, Ferruh Kemal; Daşdemir, Selçuk; Çakmakoğlu, Bedia; Şanlı, Öner; Gökkuşu, Cahide; Seçkin, Şule

doi:10.1016/j.gene.2012.09.011

Cited by 34 publications

(31 citation statements)

References 43 publications

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“…Previous studies have shown that the CXCR4 plays an essential role in cell growth in bladder cancer (Kucukgergin et al, 2012;Yates et al, 2013). We asked whether overexpression or knockdown of SRC-3 may affect CXCR4 expression.…”

Section: Src-3 Regulation Of Cxcr4 In Bladder Cancer Cellsmentioning

confidence: 98%

Steroid Receptor Coactivator-3 Promotes Bladder Cancer Through Upregulation of CXCR4

Wang¹,

Liu²,

Qu³

2013

Asian Pacific Journal of Cancer Prevention

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The three homologous members of the p160 SRC family (SRC-1, SRC-2 and SRC-3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRC-3 gene is subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRC-3 promotes breast and prostate cancer cell proliferation and survival, have been identified. However, the function of SRC-3 in bladder cancer remains poorly understood. In the present study, our results indicate that overexpression of SRC-3 promotes bladder cancer cell proliferation whereas knockdown of SRC-3 results in inhibition. At the molecular level, we further established that CXCR4 is a transcriptional target of SRC-3. Therefore, our study first identified that SRC-3 plays a critical role in the bladder cancer, which may be a target beneficial for its prevention and treatment.

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Section: Src-3 Regulation Of Cxcr4 In Bladder Cancer Cellsmentioning

confidence: 98%

Steroid Receptor Coactivator-3 Promotes Bladder Cancer Through Upregulation of CXCR4

Wang¹,

Liu²,

Qu³

2013

Asian Pacific Journal of Cancer Prevention

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“…The results suggested that the GG homozygote had a 21% decrease risk of cancer compared with those individuals with GA or AA in Asians. In the subgroup analysis by cancer type, only bladder cancer was investigated in four studies (Vazquez-Lavista et al, 2009;Narter et al, 2010;Kucukgergin et al, 2012b;Singh et al, 2012), and the pooled OR was 0.89 (95%CI = 0.32-2.45, p=0.82) for GG vs. GA +AA model , showed no association.…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

“…After HWE test, 3 articles (Saenz-Lopez et al, 2008;Attar et al, 2010;Gu et al, 2011) were deviated from HWE. Thus, a total of 11 case-control studies were extracted (VazquezLavista et al, 2009;Narter et al, 2010;Yang et al, 2010;Yeh et al, 2010;Chen et al, 2011;Kruszyna et al, 2011;Kucukgergin et al, 2012a;Kucukgergin et al, 2012b;Bektas-Kayhan et al, 2012;Singh et al, 2012;Wu et al, 2013). The characteristics of each case-control study are listed in Table 1.…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis

Jia

Shen²,

Guo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Since their initial characterization, CCR5-D32 and CCR2-V64I polymorphisms have become attractive candidates for genetic association studies of various diseases, particularly those examining the circulatory system and neoplasms (Jones et al, 2011;Lin et al, 2012;Kucukgergin et al, 2012;Tanyel et al, 2013;Zambra et al, 2013). However, for complex diseases, the actual clinical relevance of these polymorphisms remains inconclusive and studies have shown conflicting results (Vázquez-Lavista et al, 2009;Kucukgergin et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…However, for complex diseases, the actual clinical relevance of these polymorphisms remains inconclusive and studies have shown conflicting results (Vázquez-Lavista et al, 2009;Kucukgergin et al, 2012). The genetic variability of different populations worldwide may help explain the discrepancies observed in these studies, which reinforces the need for validation of studies in different populations.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

Ferreira-Fernandes

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-D32 and CCR2-V64I are related to human immunodeficiency virus infection resistance, which has led to genetic association studies for several other diseases. Given the heterogeneous distribution of these polymorphisms in different global populations and within Brazilian populations, we analyzed the prevalence of CCR5-D32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil. The study included 223 individuals from the general population of the city of Parnaíba, Piauí, who had a mean age of 73 years. Of these individuals, 37.2% were men 11711 CCR5-D32 and CCR2-V64I polymorphisms in Piauí, Brazil ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 11710-11718 (2015) and 62.8% were women. Polymorphisms were analyzed using DNA extracted from peripheral blood leukocytes by using polymerase chain reaction alone (CCR5-D32) or accompanied by restriction endonuclease digestion (CCR2-V64I). In both cases, the genotypes were determined using 8% polyacrylamide gel electrophoresis and silver nitrate staining. The population conformed to Hardy-Weinberg equilibrium for both the loci studied. No individuals were homozygous for allele-D32, which was present in 1.8% of the population, whereas allele-64I was present in 13.9% of the participants studied; 74.9% were homozygous for the wild-type allele, while 22.4 and 2.7% were heterozygous and homozygous for the mutant allele, respectively. Additional studies are needed to investigate the relationship between these polymorphisms and disease etiopathogenesis in reference populations.

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The role of chemokine and chemokine receptor gene variants on the susceptibility and clinicopathological characteristics of bladder cancer

Cited by 34 publications

References 43 publications

Steroid Receptor Coactivator-3 Promotes Bladder Cancer Through Upregulation of CXCR4

Steroid Receptor Coactivator-3 Promotes Bladder Cancer Through Upregulation of CXCR4

The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

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