The Role of CEUS in the Evaluation of Thyroid Cancer: From Diagnosis to Local Staging

Sorrenti, Salvatore; Dolcetti, Vincenzo; Fresilli, Daniele; Gaudio, Giovanni Del; Pacini, P.; Huang, Pintong; Camponovo, Chiara; Leoncini, Andrea; D’Andrea, Vito; Pironi, Daniele; Frattaroli, Fabrizio Maria; Trimboli, Pierpaolo; Radziņa, Maija; Cantisani, Vito

doi:10.3390/jcm10194559

Cited by 45 publications

(44 citation statements)

References 82 publications

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“…High-resolution US is a strongly recommended tool for the preoperative diagnosis of PTC and the evaluation of cervical LNs according to ATA guidelines. Some studies have reported that the CEUS features of PTCs could preoperatively predict the cervical LNs metastasis (14). Zhan et al found that iso-or hyperenhancement at peak time could predict cervical LNs metastasis in PTC patients (15).…”

Section: Discussionmentioning

confidence: 99%

Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

et al. 2022

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The aim of the study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). Two hundred and one cervical LNs (157 metastatic from PTC and 44 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Histopathology was used as the gold standard. We evaluated the size, long axis/short axis ratio (L/S), fatty hilum, hyper-echogenicity, calcification, cystic change, peripheral vascularity and CEUS parameters for each lymph nodule. The CEUS parameters included enhancement type, homogeneity, perfusion type, ring enhancement, peak intensity (PI) index and area under the curve (AUC) index. Univariate analysis demonstrated that compared with benign LNs, malignant LNs more frequently had L/S < 2, absence of a fatty hilum, presence of hyper-echogenicity, presence of calcification, peripheral vascularity, hyper-enhancement, heterogeneous enhancement, centripetal perfusion, ring enhancement, PI index > 1 and AUC index > 1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that hyper-enhancement, centripetal perfusion, and ring enhancement are independent CEUS characteristics related to malignant LNs for their differentiation from benign LNs (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to identify malignant cervical LNs from benign cervical LNs.

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Section: Discussionmentioning

confidence: 99%

Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

et al. 2022

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“…We hypothesize the high cytological adequacy of CEUS-FNA relates to the viable tissue targeted puncture. For one hand, CEUS accurately distinguishes viable tissues from inactive, and locates the viable tissues within nodules [ 21 , 22 ]. Viable tissues, including follicular tissue, granulation tissue, and tumor tissue are shown certain degrees of contrast enhancements under CEUS.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound improves the potency of fine-needle aspiration in thyroid nodules with high inadequate risk

et al. 2022

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Background This study aims to determine the clinical value of contrast enhanced ultrasound (CEUS) for fine-needle aspiration (FNA) of high inadequate risky thyroid nodules. Methods During April 2018 and April 2021, consecutive 3748 thyroid nodules underwent FNA were retrospectively analyzed. CEUS guided FNA (CEUS-FNA) was applied in 115 nodules with high inadequate risk in Lingnan Campus. Ten nodules underwent CEUS-FNA presented non-enhancing, and would be further analyzed independently. Other 105 partial or total enhancing nodules were included as CEUS-FNA group, and 210 nodules with high inadequate risk in Tianhe Campus were match as the US-FNA control group. FNA specimens were collected for liquid-based preparation. Cytological results were classified following the Bethesda System for Reporting Thyroid Cytopathology. Results The overall FNA specimen inadequate rate in our center was 6.6%. All of the ten non-enhancing nodules under CEUS have an inadequate result in cytopathological analyzes. The subsequent postoperative pathology and follow-up ultrasonography showed the non-enhancing nodules were benign or stable without further malignant features. Total specimen inadequate rate of high inadequate risk thyroid nodules in CEUS-FNA group was significantly lower than US-FNA group (6.7% vs. 16.7%, P = 0.014). Further stratified analyzed shown that FNA under US guidance, the inadequate rates in cystic, predominantly cystic, predominantly solid and solid sub-groups were 28.1%, 17.1%, 10.0% and 9.2% (P = 0.019). In contrast, the inadequate rates in cystic, predominantly cystic, predominantly solid and solid sub-groups were 7.4%, 6.7%, 5.6% and 6.7% (P = 0.996) in CEUS-FNA group. Conclusions CEUS can improve the specimen adequacy of FNA in high inadequate risk thyroid nodules by avoiding unnecessary FNAs of the non-enhancing nodules, and accurately locating the viable tissue and precise guidance in real-time. CEUS is a recommend modality for FNA guidance of high inadequate risk thyroid nodules.

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“…There are two significant functions of ultrasound which are for diagnostic of internal body and pregnancy. The frequency range commonly employed in medical ultrasound is 2 to 18 megahertz, hundreds of times above the human hearing range [34][35][36]. A transducer is a device that rubs the patient's skin across the area being investigated during an ultrasound.…”

Section: Body Image-based Technologymentioning

confidence: 99%

Existing and Emerging Breast Cancer Detection Technologies and Its Challenges: A Review

et al. 2021

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Breast cancer is the most leading cancer occurring in women and is a significant factor in female mortality. Early diagnosis of breast cancer with Artificial Intelligent (AI) developments for breast cancer detection can lead to a proper treatment to affected patients as early as possible that eventually help reduce the women mortality rate. Reliability issues limit the current clinical detection techniques, such as Ultra-Sound, Mammography, and Magnetic Resonance Imaging (MRI) from screening images for precise elucidation. The capability to detect a tumor in early diagnosis, expensive, relatively long waiting time due to pandemic and painful procedure for a patient to perform. This article aims to review breast cancer screening methods and recent technological advancements systematically. In addition, this paper intends to explore the progression and challenges of AI in breast cancer detection. The next state of the art between image and signal processing will be presented, and their performance is compared. This review will facilitate the researcher to insight the view of breast cancer detection technologies advancement and its challenges.

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The Role of CEUS in the Evaluation of Thyroid Cancer: From Diagnosis to Local Staging

Cited by 45 publications

References 82 publications

Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Contrast-enhanced ultrasound improves the potency of fine-needle aspiration in thyroid nodules with high inadequate risk

Existing and Emerging Breast Cancer Detection Technologies and Its Challenges: A Review

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