The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Yang, Lunyu; Zhang, Bin; Shi, Hui; Li, Rong; You, Benshuai; Wu, Peipei; Han, Xinye; Qian, Hui; Xu, Wenrong

doi:10.1155/2019/2316834

Cited by 23 publications

(25 citation statements)

References 65 publications

(76 reference statements)

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“…CircRNA CDR1as has also been found to be abundant in huMSCs. The increase of huMSC proliferation, secretion, and differentiation induced by 3,3'-diindolylmethane also increased the abundance of CDR1as, whereas the knockdown of CDR1as reduces their proliferation and differentiation capacity, which are essential for their regenerative potential (Yang et al, 2019).…”

Section: Circrnas In Mscsmentioning

confidence: 96%

Circular RNAs in Cardiac Regeneration: Cardiac Cell Proliferation, Differentiation, Survival, and Reprogramming

Mester-Tonczar¹,

Hašimbegović²,

Spannbauer³

et al. 2020

Front. Physiol.

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Circular RNAs (circRNAs) are classified as long non-coding RNAs (lncRNAs) that are characterized by a covalent closed-loop structure. This closed-loop shape is the result of a backsplicing event in which the 3' and 5' splice sites are ligated. Through the lack of 3' poly(A) tails and 5' cap structures, circRNAs are more stable than linear RNAs because these adjustments make the circular loop less susceptible to exonucleases. The majority of identified circRNAs possess cell-and tissue-specific expression patterns. In addition, high-throughput RNA-sequencing combined with novel bioinformatics algorithms revealed that circRNA sequences are often conserved across different species suggesting a positive evolutionary pressure. Implicated as regulators of protein turnover, micro RNA (miRNA) sponges, or broad effectors in cell differentiation, proliferation, and senescence, research of circRNA has increased in recent years. Particularly in cardiovascular research, circRNArelated discoveries have opened the door for the development of potential diagnostic and therapeutic tools. Increasing evidence links deviating circRNA expression patterns to various cardiovascular diseases including ischemic heart failure. In this mini-review, we summarize the current state of knowledge on circRNAs in cardiac regeneration with a focus on cardiac cell proliferation, differentiation, cardiomyocyte survival, and cardiac reprogramming.

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Section: Circrnas In Mscsmentioning

confidence: 96%

Circular RNAs in Cardiac Regeneration: Cardiac Cell Proliferation, Differentiation, Survival, and Reprogramming

Mester-Tonczar¹,

Hašimbegović²,

Spannbauer³

et al. 2020

Front. Physiol.

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“…Of note, the expression level of a large diversity of circRNAs have been changed during chondrogenic differentiation of MSCs [ 125 ]. Among them, CircRNA-CDR1as has been validated to maintain the differentiation and proliferation of human umbilical cord MSCs [ 126 ]. Thus, circRNAs may be utilized as the regulator to determine the differentiation trend and speed during the MSCs therapy, which pave the way for customized treatment.…”

Section: Potential Clinical Utilizations Of Circrnas In Oamentioning

confidence: 99%

Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

Zhang

Chen

et al. 2021

Arthritis Res Ther

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Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in the development and progression of many diseases including osteoarthritis (OA). OA is a prevalent disease that mainly affects those aging, obese and post-traumatic population, posing as a major source of socioeconomic burden. Recently, numerous circRNAs have been found aberrantly expressed in OA tissues compared with counterparts. More importantly, circRNAs have been demonstrated to interplay with components in OA microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. Herein, in this review, we extensively summarize the roles of circRNAs in OA microenvironment, progression, and putative treatment, as well as envision the future directions for circRNAs research in OA, with the aim to provide a novel insight into this field.

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“…As CDR1as can regulate the activity of miR-7 by sponging it, CDR1as exerts a wide range of physiological and pathological effects (Li et al, 2018b). Accordingly, CDR1as plays an important role in cellular proliferation and differentiation as well as cancer invasion and metastasis (Yan et al, 2018;Li L. et al, 2019;Wang et al, 2019;Yang L. et al, 2019;Zhou et al, 2019;Zou et al, 2019;Chen et al, 2020;Hanniford et al, 2020;Yang et al, 2020;Zhao F. et al, 2020).…”

Section: The Biological Functions Of Cdr1asmentioning

confidence: 99%

“…Among these miRNAs, miR-7 functions as a tumor suppressor in many cancer types, such as osteosarcoma, breast cancer, hepatocellular carcinoma, and colorectal cancer (Yu et al, 2016;Tang et al, 2017;Xu et al, 2018). CDR1as was found to promote the proliferation and metastasis of cancer cells by sponging miR-7 (Tang et al, 2017;Xu et al, 2018;Yang L. et al, 2019). Furthermore, since conserved miR-7 target sites on CDR1as are complementary to miR-7, these sites could be a lodging site for transport (Memczak et al, 2013;Piwecka et al, 2017).…”

Section: Cdr1as Functions As a Mirna Spongementioning

confidence: 99%

The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer

Jiang

Zeng

Shan

et al. 2020

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are covalently closed circular structures without 5′ caps and 3′ tails, which are mainly formed from precursor mRNAs (pre-mRNAs) via back-splicing of exons. With the development of RNA sequencing and bioinformatic analysis, circRNAs were recently rediscovered and found to be widely expressed in the tree of life. Cerebellar degeneration-related protein 1 antisense RNA (CDR1as) is recognized as one of the most well-identified circRNAs. It contains over 70 miR-7 binding sites and can regulate gene activity by sponging miR-7. Increasing numbers of studies have recently demonstrated that CDR1as is abnormally expressed in many types of tumors, such as colorectal cancer, cholangiocarcinoma and osteosarcoma, and plays a vital role in the development of cancer. However, there are few reviews focusing on CDR1as and cancer. Hence, it is important to review and discuss the role of CDR1as in cancer. Here, we first review the main biological features of CDR1as. We then focus on the expression and roles of CDR1as in cancer. Finally, we summarize what is known on the role of CDR1as in cancer and discuss future prospects in this area of research.

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The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Cited by 23 publications

References 65 publications

Circular RNAs in Cardiac Regeneration: Cardiac Cell Proliferation, Differentiation, Survival, and Reprogramming

Circular RNAs in Cardiac Regeneration: Cardiac Cell Proliferation, Differentiation, Survival, and Reprogramming

Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer

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