2021
DOI: 10.1016/j.lfs.2021.119150
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The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy

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Cited by 46 publications
(41 citation statements)
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“…In recent years, pre-clinical studies on the concept of tumor microenvironment (TME) have revealed a variety of immune cells interacting with each other and, respectively, regulating tumorigenesis or immune regulation. Research results showed that CD47-SIRPα immune checkpoint pathway played important roles in tumor immune evasion and innate immunotherapy [ 31 ]. The expression of CD47 also has an important impact on the construction of TME [ 32 ], whereas CD47 deficiency led to cancer stem cell depletion.…”
Section: Sirpα-cd47 Signal Pathwaymentioning
confidence: 99%
See 1 more Smart Citation
“…In recent years, pre-clinical studies on the concept of tumor microenvironment (TME) have revealed a variety of immune cells interacting with each other and, respectively, regulating tumorigenesis or immune regulation. Research results showed that CD47-SIRPα immune checkpoint pathway played important roles in tumor immune evasion and innate immunotherapy [ 31 ]. The expression of CD47 also has an important impact on the construction of TME [ 32 ], whereas CD47 deficiency led to cancer stem cell depletion.…”
Section: Sirpα-cd47 Signal Pathwaymentioning
confidence: 99%
“…A potential explanation for the differential binding of CD47 mAbs to different cells could be due to the fact that CD47 associates with different membrane proteins (in cis ) on different cells. Therefore, certain epitopes may be masked by CD47 binding partners in different cells (such as erythrocyte membrane protein 4.2 and/or Rh complex components [ 37 ]), or dependent on CD47 interacting proteins (such as integrin [ 31 ]), or physically associated with other membrane proteins (such as VEGFR2) [ 31 ]. Because CD47 can be heavily glycosylated with five potential NXT/S sequences in its extracellular IgV domain [ 38 ] and/or modified by addition of glycosaminoglycans, differing patterns or extents of carbohydrate additions in different cell types could also explain the differential binding of CD47 antibodies [ 39 ].…”
Section: Sirpα-cd47 Signal Pathwaymentioning
confidence: 99%
“…The CD47-SIRPα signaling system is a cell-cell communication system ( Zhang H. et al, 2015 ; Matlung et al, 2017 ; Weiskopf, 2017 ). CD47-SIRPα interactions have been termed an innate immune checkpoint in macrophages ( Li et al, 2021 ). Blockade of anti-phagocytic CD47-SIRPα interactions using humanized antibodies to CD47 (Hu5F9-G4) has yielded promising results in preclinical studies of a number of human malignancies including pediatric brain tumors: medulloblastoma, atypical teratoid rhabdoid tumors, primitive neuroectodermal tumor, pediatric glioblastoma, and diffuse intrinsic pontine glioma ( Gholamin et al, 2017 ) and accelerates the clearance of hematomas in experimental intraventricular hemorrhage ( Ye et al, 2021 ).…”
Section: The Small Neural Proteoglycansmentioning
confidence: 99%
“…Deficient levels of HA in PNN structures promote epilepsy and spontaneous convulsions in animal models (Perkins et al, 2017). The CS-PGs of PNNs have important functional roles to play in perisynaptic structures that prevent the development Zhang H. et al, 2015;Matlung et al, 2017;Bedoui et al, 2018;Hutter et al, 2019;Li et al, 2021…”
Section: Roles For the Cs-rich Lectican Pg Family In Perineuronal Net Structuresmentioning
confidence: 99%
“…Surface CRT is able to induce an “eat me” signal to phagocytes [ 307 ], increasing their activity along with DC maturation and antigen-presenting function [ 308 ]. The calreticulin effect is antagonized by the interaction of CD47 present on the tumor cell membrane with SIRP-alpha α located on macrophages and DC [ 309 ]), generating a “do not eat me” message in target phagocytes [ 310 ]. Increased expression of HSP90 and HSP70 by ICD inducers [ 247 ].…”
Section: Figurementioning
confidence: 99%