The role of CD45+CD4+CD3– cells in lymphoid organ development

Cupedo, Tom; Kraal, Georg; Mebius, Reina E.

doi:10.1034/j.1600-065x.2002.18905.x

Cited by 77 publications

(67 citation statements)

References 78 publications

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“…RU, relative units. ment of LTi cells, which initiate the formation and organization of lymphoid organs, such as LNs and Peyer patches (21). Thus, the induced expression of CXCL13 may recruit similar types of cells to the lung, which initiate the formation of iBALT.…”

Section: Figurementioning

confidence: 99%

“…The coordinated activities of these chemokines maintain the compartmentalized structure of lymphoid tissues and make encounters between lymphocytes and activated, antigen-bearing APCs more likely (11,12), ultimately leading to more efficient immune responses (16,17). Homeostatic chemokines are also important for the development of lymphoid organs during embryogenesis (18)(19)(20)(21) and are expressed in ectopic lymphoid structures in murine and human diseases characterized by chronic inflammation (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). In each case, the formation of ectopic lymphoid follicles is thought to be triggered by chronic inflammation caused by autoimmunity or infection (reviewed in refs.…”

Section: Introductionmentioning

confidence: 99%

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Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

Rangel-Moreno¹,

Hartson²,

Navarro³

et al. 2006

J. Clin. Invest.

407

359

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Bronchus-associated lymphoid tissue (BALT) was originally described as a mucosal lymphoid organ in the lungs of some species. However, while the lungs of naive mice and humans typically lack BALT, pulmonary infection in mice leads to the development of inducible BALT (iBALT), which is located in peribronchial, perivascular, and interstitial areas throughout the lung. Here we investigated whether iBALT forms in patients with a variety of interstitial lung diseases. We show that while iBALT can be found in the lungs of patients suffering from multiple diseases, well-developed iBALT is most prevalent in patients with pulmonary complications of RA and Sjögren syndrome. In these patients, iBALT consisted of numerous B cell follicles containing germinal centers and follicular dendritic cells. A loosely defined T cell area surrounded the B cell follicles while lymphatics and high endothelial venules were found at the B cell/T cell interface. Increased expression of lymphoid-organizing chemokines, such as CXCL13 and CCL21, as well as molecules involved in the immunopathology of RA, such as B cell-activating factor of the TNF family (BAFF), ICOS ligand, and lymphotoxin, correlated with more well-developed iBALT. Finally, the presence of iBALT correlated with tissue damage in the lungs of RA patients, suggesting that iBALT participates in local RA pathogenesis.

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

Rangel-Moreno¹,

Hartson²,

Navarro³

et al. 2006

J. Clin. Invest.

407

359

View full text Add to dashboard Cite

show abstract

“…The absence of PP and LN in these mice cannot be restored by LT/LT␤R-dependent events later in life (10,11). The cellular source of LT required for the formation of PP and LN is believed to be a bone marrow-derived, CD4 ϩ , CD3 Ϫ , non-T and non-B lymphocyte precursor, which can be a progenitor of NK cells and dendritic cells (12)(13)(14). These requirements for gestational-dependent, LT/LT␤R-dependent events appear to be universal for the formation of secondary lymphoid structures, although the formation of cervical LN and MLN in the absence of these signals has been reported (15).…”

mentioning

confidence: 99%

Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin β Receptor, and TNF Receptor I Function

Lorenz

Chaplin

McDonald

et al. 2003

The Journal of Immunology

255

362

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The gastrointestinal mucosa contains a complex network of lymphoid compartments that have evolved to efficiently protect the host from invading pathogens. Recently, an additional lymphoid structure resembling Peyer’s patches (PP) in composition and architecture has been identified in the murine small intestine, the isolated lymphoid follicle (ILF). In this study we examine the nature and factors required for ILF formation. We observed a spectrum of structures fitting the previous descriptions of ILFs, ranging from clusters of B220+ cells (which we have termed immature ILFs) to well-organized lymphoid nodules (which we have termed mature ILFs). Here we demonstrate that that similar to PP formation, ILF formation requires lymphotoxin (LT)- and LTβ receptor-dependent events. However unlike PP formation, the LT- and LTβ receptor-dependent events required for ILF formation can occur in adulthood and require LT-sufficient B lymphocytes. We demonstrate that mature ILF formation occurs in response to lumenal stimuli, including normal bacterial flora, and requires TNF receptor I function. These findings suggest that ILFs are organized intestinal lymphoid structures whose formation can be induced and whose mass can be expanded in response to mucosal challenges.

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“…6A, 6B), suggesting that LTb functions during NKT1 a subset development in a noncell-autonomous manner. We subsequently generated mice lacking LTb within the B lymphocyte (CD79a-cre;LTb F/F ), lymphoid tissue inducer (LTi, RORgt-cre;LTb F/F ), and dendritic cell (CD11c-cre;LTb F/F ) compartments, as previous studies have identified roles for these cellular lineages in secondary lymphoid organ formation and lymphocyte homeostasis (32)(33)(34). However, analysis of NKT1 a development in CD79a-cre;LTb F/F (Fig.…”

Section: Noncell-autonomous Requirement For Ltb During Nkt1 a Developmentioning

confidence: 99%

The Thymic Microenvironment Differentially Regulates Development and Trafficking of Invariant NKT Cell Sublineages

Drennan

Govindarajan

Wilde

et al. 2014

The Journal of Immunology

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The regulatory role of the thymic microenvironment during trafficking and differentiation of the invariant NKT (iNKT) cell lineage remains poorly understood. In this study, we show that fractalkine receptor expression marks emigrating subpopulations of the NKT1, NKT2, and NKT17 sublineages in the thymus and peripheral organs of naive mice. Moreover, NKT1 sublineage cells can be subdivided into two subsets, namely NKT1a and NKT1b, which exhibit distinct developmental and tissue-specific distribution profiles. More specifically, development and trafficking of the NKT1a subset are selectively dependent upon lymphotoxin (LT)α1β2-LTβ receptor–dependent differentiation of thymic stroma, whereas the NKT1b, NKT2, and NKT17 sublineages are not. Furthermore, we identify a potential cellular source for LTα1β2 during thymic organogenesis, marked by expression of IL-7Rα, which promotes differentiation of the NKT1a subset in a noncell-autonomous manner. Collectively, we propose a mechanism by which thymic differentiation and retention of the NKT1 sublineage are developmentally coupled to LTα1β2-LTβ receptor–dependent thymic organogenesis.

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The role of CD45⁺CD4⁺CD3^– cells in lymphoid organ development

Cited by 77 publications

References 78 publications

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin β Receptor, and TNF Receptor I Function

The Thymic Microenvironment Differentially Regulates Development and Trafficking of Invariant NKT Cell Sublineages

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