The role of catalases in the prevention/promotion of oxidative stress

Gębicka, Lidia; Krych-Madej, Justyna

doi:10.1016/j.jinorgbio.2019.110699

Cited by 111 publications

(48 citation statements)

References 77 publications

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“…Moreover, conversion of H 2 O 2 into harmless forms by GPx occurs with the concomitant oxidation of reduced glutathione (GSH) into the oxidized form (GSSG), and glutathione reductase recycles GSSG to GSH. Thus, it is supposed that the main limiting factor for GPx in scavenging higher amounts of H 2 O 2 is the rate of recycling of GSH/thioredoxin, which is necessary to maintain the catalytic cycle [101,102]. On the other hand, the MSC-treated group of mice with induced oxidative stress accompanying colitis exhibited greater GSH levels than the untreated group and these were similar to that observed in the control group [103].…”

Section: Discussionmentioning

confidence: 52%

Influence of Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Oxidative Stress Intensity in Minimally Conscious State Patients

Jezierska-Woźniak

Sinderewicz

Czelejewska

et al. 2020

JCM

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Neurological disorders, including minimally conscious state (MCS), may be associated with the presence of high concentrations of reactive oxygen species within the central nervous system. Regarding the documented role of mesenchymal stem cells (MSCs) in oxidative stress neutralization, the aim of this study is to evaluate the effect of bone marrow-derived MSC (BM-MSC) transplantation on selected markers of oxidative stress in MCS patients. Antioxidant capacity was measured in cerebrospinal fluid (CSF) and plasma collected from nine patients aged between 19 and 45 years, remaining in MCS for 3 to 14 months. Total antioxidant capacity, ascorbic acid and ascorbate concentrations, superoxide dismutase, catalase, and peroxidase activity were analyzed and the presence of tested antioxidants in the CSF and plasma was confirmed. Higher ascorbic acid (AA) content and catalase (CAT) activity were noted in CSF relative to plasma, whereas superoxide dismutase (SOD) activity and total antioxidant capacity were higher in plasma relative to CSF. Total antioxidant capacity measured in CSF was greater after BM-MSC transplantations. The content of ascorbates was lower and CAT activity was higher both in CSF and plasma after the administration of BM-MSC. The above results suggest that MSCs modulate oxidative stress intensity in MCS patients, mainly via ascorbates and CAT activity.

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Section: Discussionmentioning

confidence: 52%

Influence of Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Oxidative Stress Intensity in Minimally Conscious State Patients

Jezierska-Woźniak

Sinderewicz

Czelejewska

et al. 2020

JCM

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“…GSH is a redox molecule considered as one of the most effective cellular non-enzymatic antioxidants in the body. Its redox status is under the control of a biological mechanism involving both glutathione peroxidase (GPx) which catalyzes the oxidation of GSH and glutathione reductase (GRd) which catalyzes the reduction of oxidized form of GSH, using NADPH as a hydrogen donor [81]. Hence, the hepatic activities of these enzymes (GPx and GRd) together with the level of GSH are used as markers for oxidative stress and cytotoxicity.…”

Section: And Rifampicin Toxicitymentioning

confidence: 99%

Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat

2021

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Background Persea americana (PA) is a popular medicinal plant in folkloric medicines. The present study therefore investigates the ameliorative potentials of its leaves extract on carbon tetrachloride and rifampicin-induced toxicity in the liver, kidney and heart of albino rat. This was aimed at assessing the potentials of the plant in the management of liver, kidney and heart diseases. Methodology Forty (40) rats were randomly divided into eight (8) groups of five animals each. Groups I and II were administered with only distilled water and carbon tetrachloride (CCl4) respectively. Groups III and IV animals received 3.0 ml/kg bw of CCl4 and were treated with the extract at 50 mg/kg bw and 100 mg/kg respectively, while group V received 100 mg/kg bw. of silymarin orally for 14 days. Groups VI animals were administered with rifampicin (250 mg/kg bw.) only, while groups VII and VIII animals received rifampicin and were treated with 50 mg and 100 mg/kg bw of the extract respectively. Activities of creatine kinase, aspartate amino transferase, alanine amino transferase, alkaline phosphatase, superoxide dismutase, catalase as well as levels of urea, uric acid, bilirubin and malonidialdehyde (MDA) were assayed. Lipid profiles and histopathological examination of liver and kidney slices were also performed. Result Treatment with P. americana significantly (p < 0.05) restored all deranged biochemical parameters (creatine kinase, aspartate amino transferase, alanine amino transferase, alkaline phosphatase, urea, uric acid, bilirubin, MDA, lipid profile as well as superoxide dismutase and catalase) in a dose-dependent manner. Normal hepatic and renal histoarchitecture were also restored following treatment with P. americana. Conclusion Amelioration of distorted cardiac, hepatic and renal histoarchitecture as well as restoration of lipid profile, biomarkers of liver and kidney injury and antioxidant enzymes (catalase and superoxide dismutase) affirm the potential usefulness of P. americana in the management of liver, kidney and heart diseases.

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“…When H 2 O 2 concentration is low, catalase can return to the native enzyme oxidizing secondary two-electron donors, e.g., low molecular alcohols (peroxidatic activity). A secondary two-electron donor participates in the second step of Equation (1) [9]. However, under certain conditions, Compound II can be created, but it cannot be effectively reduced to the native enzyme and therefore its accumulation leads to the catalase deactivation.…”

Section: Introductionmentioning

confidence: 99%

“…Compound III structurally 2 of 12 resembles oxy forms of mioglobin and hemoglobin. It can be generated in the reactions of Compound II with hydrogen peroxide, or ferric catalases with superoxide [9].…”

Section: Introductionmentioning

confidence: 99%

New Method of Determining Kinetic Parameters for Decomposition of Hydrogen Peroxide by Catalase

Trawczyńska

2020

Catalysts

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The presented study investigates the kinetic properties of catalase during hydrogen peroxide decomposition reaction. A novel and simple method is hereby proposed for the determination of the enzyme deactivation rate constant (kd) and the decomposition of H2O2 reaction rate constant (kr). Available methods allow the kd constant to be determined only based on previously experimentally determined kr. The presented method differs from the conventional procedure. Known initial and final concentrations of hydrogen peroxide enable determination of both constants at the same time based on data from only one experiment. The correctness of the new method proposed here in determining the reaction rate constant was checked by comparing the obtained constant values with the calculated values according to the commonly used Aebi method. The method was used to analyze in detail the effect of pH (3–10) and temperature (10–45 °C) of the reaction medium on kinetic constants. The value of the constant kd increases together with the value of pH and temperature. In addition, the activation energy for decomposition reaction and deactivation reaction was found to be Er = 14 kJ mol−1 and Ed = 56.8 kJ mol−1 respectively.

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The role of catalases in the prevention/promotion of oxidative stress

Cited by 111 publications

References 77 publications

Influence of Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Oxidative Stress Intensity in Minimally Conscious State Patients

Influence of Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Oxidative Stress Intensity in Minimally Conscious State Patients

Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat

New Method of Determining Kinetic Parameters for Decomposition of Hydrogen Peroxide by Catalase

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