The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers

Abstract

Catalase (CAT), one antioxidant enzyme, may provide resistance against many diseases. Many previous studies reported predictive and prognostic values of CAT C262T polymorphism in cancers, with divergent results. This study aimed to summarize the overall relationships between CAT C262T polymorphism and cancer risk or survival. A total of 27 eligible publications were included in susceptibility analysis, while 8 publications contained survival outcomes. The results revealed significant relationship between CAT C262T polymorphism and cancer risk(TT + CT vs CC: OR = 1.05, 95%CI = 1.00–1.10, P = 0.036), subgroup analyses indicated the CAT C262T polymorphism was significantly correlated with an increased risk for prostate cancer (TT vs CC + CT: OR = 1.43, 95%CI = 1.20–1.70, P < 0.001) and increased risk among Caucasians (TT vs CC + CT: OR = 1.19, 95%CI = 1.09–1.31, P < 0.001), while no associations between the polymorphism and Asian or mixed population were established. In the survival analysis, no interactions were identified between this polymorphism and cancer survival (TT + CT vs CC: HR = 1.37, 95%CI = 0.70–2.70, P = 0.36). In conclusion, the CAT C262T polymorphismmay be a candidate markerfor cancer risk with type-specific and population-specific effects but not a fine prognostic factor for cancer survival.

The Influence of GPX1 Pro198Leu, CAT C262T and MnSOD Ala16Val Gene Polymorphisms on Susceptibility for Non-Hodgkin Lymphoma and Overall Survival Rate at Five Years from Diagnosis

“…In a recent meta-analysis [17] of several studies regarding different cancer types, including hematological ones, it was suggested that the CAT C262T polymorphism may be associated with cancer susceptibility, and even more, may be considered a potential tumor biomarker. Nevertheless, the CAT C262T polymorphism is not considered an accurate prognostic factor for cancer survival rate [17]. According to our results, the CAT C262T is not a risk factor for NHL development, but it was associated with lower overall survival rate in dominant model.…”

“…According to SNPedia [15] and NCBI [16], there is a consistent number of single nucleotide polymorphisms (SNPs) of the human catalase gene. In the last few years, there has been a significant number of case-control and meta-analysis studies [17,18] focusing on the CAT C262T polymorphism (substitution of Cytosine with Thymine in the 262 position of the promotor) involved in the progression of neoplasia, but more studies regarding NHL are still needed [10,19].…”

A study on Catalase Gene Promoter Polymorphism-21 A/T (rs7943316) in Healthy Pakistani population

“…Different studies have showed the role of CAT gene promoter polymorphism in disease susceptibility, especially diseases related to metabolic disorders. 2 , 3 , 4 , 9 CAT -21A/T (rs7943316) gene TT genotype was observed in 80% of T2DM patients along with lower CAT enzyme activity. 10 Cerebral stroke and hypertension patients showed the association of CAT -21A/T (rs7943316) gene polymorphism with increased risk of disease pathogenesis.…”

“… 1 Most of the antioxidant enzyme genes have susceptibility for polymorphism and may contribute in the alteration of gene expressions and decrease the activity of these enzymes. 2 Different metabolic disorders are shown to be associated with the modified antioxidant enzymes functions. 3 Catalase (CAT) is one of the powerful antioxidant enzymes because of its highest turnover rate and exists in almost all aerobically respiring organisms.…”

Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer

“…Genetic variation in CAT have been found to associate with impaired CAT activity and certain diseases [41]. Two common CAT SNPs, rs1001179 and rs794316, were found to be associated with prostate cancer risk and survival [42,43]. So far, there is no riskrelated CAT polymorphisms identified in gastric cancer [44,45].…”