The Role of Carrier in Dry Powder Inhaler

Hamishehkar, Hamed; Rahimpour, Yahya; Javadzadeh, Yousef

doi:10.5772/51209

Cited by 23 publications

(19 citation statements)

References 111 publications

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“…Table 1 contains the w/w % compositions of these samples. The carrier-based formulation (mCIP þ IH70)as a reference [38] was prepared with mixing in 1:10 [39] mass ratio of the drug and carrier by turbula blending (Turbula System Schatz; Willy A. Bachofen AG Maschinenfabrik, Basel, Switzerland) for half an hour at 60 rpm [36]. The carrier-free formulation (CIP_0.5NaSt_spd) was produced from a solution with co-spray-drying of CIP and NaSt.…”

Section: Preparation Of the Samplesmentioning

confidence: 99%

Stability test of novel combined formulated dry powder inhalation system containing antibiotic: physical characterization andin vitro–in silicolung deposition results

Benke

Farkas

Balásházy

et al. 2019

Drug Development and Industrial Pharmacy

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Objective: The aim was to study the stability of dry powder inhaler (DPI) formulations containing antibiotic with different preparation wayscarrier-based, carrier-free, and novel combined formulationand thereby to compare their physicochemical and in vitro-in silico aerodynamical properties before and after storage. Presenting a novel combined technology in the field of DPI formulation including the carrierbased and carrier-free methods, it is the most important reason to introduce this stable formulation for the further development of DPIs. Methods: The structure, the residual solvent content, the interparticle interactions, the particle size distribution and the morphology of the samples were studied. The aerodynamic values were determined based on the cascade impactor in vitro lung model. We tested the in silico behavior of the novel combined formulated samples before and during storage. Results: The physical measurements showed that the novel combined formulated sample was the most favorable. It was found that thanks to the formulation technique and the use of magnesium stearate (MgSt) has a beneficial effect on the stability compared with the carrier-based formulation without MgSt and carrier-free formulations. The results of in vitro and in silico lung models were consistent with the physical results, so the highest deposition was found for the novel combined formulated sample during the storage. Conclusions: It can be established that after the storage a novel combined formulated DPI contained amorphous drug to have around 2.5 lm mass median aerodynamic diameter and nearly 50% fine particle fraction predicted high lung deposition in silico also.

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Section: Preparation Of the Samplesmentioning

confidence: 99%

Stability test of novel combined formulated dry powder inhalation system containing antibiotic: physical characterization andin vitro–in silicolung deposition results

Benke

Farkas

Balásházy

et al. 2019

Drug Development and Industrial Pharmacy

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“…Impingers, in comparison, consists of a liquid collection surface. 1 Using these apparatuses to the standards of the BP, a direct link can be made with the mass of therapeutically active pharmaceutical ingredient (API) and particle aerodynamic size. This can be used as an indication of where deposition occurs in the respiratory tract.…”

Section: Introductionmentioning

confidence: 99%

Comparison between the next generation impactor and the twin glass impinge as model pulmonary drug delivery devices

2019

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“…29 The lungs have an enormous absorptive surface area (∼80-120 m 2 ), 10 extremely thin mucosal membrane, good supply of blood, low intracellular and extracellular enzyme activity and avoidance of first pass hepatic metabolism; so these properties make lungs a good site for systemic delivery of peptide and proteins. 20,30 Delivery of sufficient dose of drug to special target needs an efficient carrier. A good delivery system can prepare a long acting form of insulin that would improve patients' compliance.…”

Section: Pulmonary Administrationmentioning

confidence: 99%

Non-Invasive and Less Degradative Ways of Insulin Administration

Allahyari

Javadzadeh

2019

Pharm Sci

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Protein and peptide delivery systems attract great attention nowadays. They play crucial role in several diseases, but their way of administration has some disadvantages that makes patients dissatisfied. In this study, we choose insulin as a peptide that is used for type I and type II diabetic patients, but injection way of its usage is not suitable in diabetes as a chronic remedy. Although oral way is a needle-free one, but its bioavailability through that would be decreased because of degradation in gastro-intestine and consequently, further dosage should be used to get the desired hypoglycemic effect. Administration of insulin through non-parenteral and less enzymatic pathways, such as intranasal, pulmonary, transdermal, colon and vaginal routes, is new that attracts researchers’ attention considerably. Although the bioavailability of insulin may be lower than the current injection way, but it may be improved by some strategies like the use of permeation enhancers. There are also some limitations in each way, but propagation of them would result in improvement of patients’ quality of life and may cause some economic profits. The objective of this review was to introduce the convenient ways for long term insulin administration with few enzymatic barriers.

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The Role of Carrier in Dry Powder Inhaler

Cited by 23 publications

References 111 publications

Stability test of novel combined formulated dry powder inhalation system containing antibiotic: physical characterization andin vitro–in silicolung deposition results

Stability test of novel combined formulated dry powder inhalation system containing antibiotic: physical characterization andin vitro–in silicolung deposition results

Comparison between the next generation impactor and the twin glass impinge as model pulmonary drug delivery devices

Non-Invasive and Less Degradative Ways of Insulin Administration

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