The Role of Cardiac Rehabilitation in Reducing Major Adverse Cardiac Events in Heart Transplant Patients

Uithoven, Katelyn E.; Smith, Joshua R.; Medina‐Inojosa, José R.; Squires, Ray W.; Olson, Thomas P.

doi:10.1016/j.cardfail.2020.01.011

Cited by 23 publications

(16 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 Importantly, a dose response relationship exists between the number of CR sessions attended and the associated reduction in mortality and major adverse cardiac and cerebrovascular event rates. 16,17,20,21,23,32 Despite the low CR participation rates in females, CR has been shown to elicit similar or greater mortality benefit in females compared with males. 13,14,16,19,22,33 Sex differences in the temporal trends in CR participation are unclear.…”

Section: Sex Differences In Cr Participationmentioning

confidence: 99%

Sex Differences in Cardiac Rehabilitation Outcomes

Smith

Thomas

Bonikowske

et al. 2022

Circulation Research

Self Cite

View full text Add to dashboard Cite

Cardiovascular disease is a leading cause of morbidity and mortality in males and females in the United States and globally. Cardiac rehabilitation (CR) is recommended by the American Heart Association/American College of Cardiology for secondary prevention for patients with cardiovascular disease. CR participation is associated with improved cardiovascular disease risk factor management, quality of life, and exercise capacity as well as reductions in hospital admissions and mortality. Despite these advantageous clinical outcomes, significant sex disparities exist in outpatient phase II CR programming. This article reviews sex differences that are present in the spectrum of care provided by outpatient phase II CR programming (ie, from referral to clinical management). We first review CR participation by detailing the sex disparities in the rates of CR referral, enrollment, and completion. In doing so, we discuss patient, health care provider, and social/environmental level barriers to CR participation with a particular emphasis on those barriers that majorly impact females. We also evaluate sex differences in the core components incorporated into CR programming (eg, patient assessment, exercise training, hypertension management). Next, we review strategies to mitigate these sex differences in CR participation with a focus on automatic CR referral, female-only CR programming, and hybrid CR. Finally, we outline knowledge gaps and areas of future research to minimize and prevent sex differences in CR programming.

show abstract

Section: Sex Differences In Cr Participationmentioning

confidence: 99%

Sex Differences in Cardiac Rehabilitation Outcomes

Smith

Thomas

Bonikowske

et al. 2022

Circulation Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cardiac rehabilitation for patients undergoing HTX has been shown to be safe and was associated with a decrease in the occurrence of stroke, coronary revascularization, heart failure, myocardial infarction, acute rejection, or death from any cause. 30 Early detection of HTX patients with decreased functional capacity could favor the implementation of a therapy based on cardiovascular rehabilitation to prevent hospitalizations, mainly due to rejection and infections.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of cardiopulmonary exercise test after heart transplantation

Iglesias

Masson

Barbagelata

et al. 2021

Clinical Transplantation

View full text Add to dashboard Cite

Background:The clinical utility of cardiopulmonary exercise testing (CPET) has not been extensively studied yet in heart transplantation (HTX) patients. Objective:To analyze the predictive value of the CPET on hospitalizations and mortality in HTX recipients.Methods: A retrospective cohort was performed from a secondary database.Patients > 18 years with HTX who underwent a CPET between 3 and 12 months after transplantation were included. Time to the first primary endpoint (HTX-related hospitalization) was analyzed and adjusted using Cox proportional hazards regression model.Results: A total of 122 patients (mean age 50.1 years, 77.0% men) were included. Fiftyseven patients (46.7%) had the primary endpoint. Peak VO 2 (HR .95; CI 95% .90-.99, P = .03), oxygen pulse (HR .57; CI 95% .34-.96, P = .03) and predicted VO 2 (HR .97; CI 95% .96-.99, P = .002) were associated with the endpoint. We did not find a significant association between the other variables and the outcome. Conclusion:In HTX recipients, peak VO 2 , oxygen pulse, and predicted VO 2 were independently associated with hospitalizations at follow up.

show abstract

“…There is a growing interest in the role of multidisciplinary preoperative exercise training, termed prehabilitation, to prepare elderly and frail patients for major surgical procedures. Early evidence from pilot studies have been encouraging demonstrating improvements in exercise performance among heart transplant candidates and recipients [45][46][47]. Recently, the Prehabilitation in Patients Awaiting Heart Transplantation (PREHAB HTx NCT02957955) trial to evaluate the change in functional capacity after 12 week pretransplant rehabilitation program versus standard of care completed enrollment [48 & ].…”

Section: Prehabilitationmentioning

confidence: 99%

Patient selection for heart transplant: balancing risk

Mantha

Lee

Wolfson

2021

Current Opinion in Organ Transplantation

View full text Add to dashboard Cite

Purpose of reviewHeart failure incidence continues to rise despite a relatively static number of available donor hearts. Selecting an appropriate heart transplant candidate requires evaluation of numerous factors to balance patient benefit while maximizing the utility of scarce donor hearts. Recent research has provided new insights into refining recipient risk assessment, providing additional tools to further define and balance risk when considering heart transplantation. Recent findingsRecent publications have developed models to assist in risk stratifying potential heart transplant recipients based on cardiac and noncardiac factors. These studies provide additional tools to assist clinicians in balancing individual risk and benefit of heart transplantation in the context of a limited donor organ supply.

show abstract

The Role of Cardiac Rehabilitation in Reducing Major Adverse Cardiac Events in Heart Transplant Patients

Cited by 23 publications

References 49 publications

Sex Differences in Cardiac Rehabilitation Outcomes

Sex Differences in Cardiac Rehabilitation Outcomes

Prognostic value of cardiopulmonary exercise test after heart transplantation

Patient selection for heart transplant: balancing risk

Contact Info

Product

Resources

About