The role of cannabinoid CB1 receptors in the antinociceptive and reparative actions of mesenchymal stem cells in rats with peripheral neuropathic pain
Anna‐Maria V. Yerofeyeva,
Sergey V. Pinchuk,
Svetlana N. Rjabceva
et al.
Abstract:Mesenchymal stem cells (MSCs) can produce antinociceptive and reparative effects. Presumably, the MSCs‐induced antinociception may be partly due to the involvement of the endocannabinoid system. The study aimed to evaluate the antinociceptive and reparative effects of adipose‐derived MSCs (ADMSCs) upon pharmacological modulation of cannabinoid CB1 receptor in peripheral tissues or on ADMSCs' membranes in a rat model of peripheral neuropathy. ADMSCs were injected into the area of rat sciatic nerve injury (i) wi… Show more
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