The role of candidate genetic polymorphisms in the etiology of prostate cancer

Abstract

Prostate cancer appears to result from complex interactions among genetic, endocrine and environmental factors. Identi®cation of risk factors for development and progression of prostate cancer is needed. This will allow researchers to design strategies to reduce the morbidity and mortality from this cancer and to identify individuals at increased risk of developing the disease. It is probable that common genetic polymorphisms (variants) in genes directly and indirectly involved in androgen biosynthesis, metabolism and regulation are important. Other important genes are likely to be those directly involved in regulation of prostate cell proliferation and apoptosis. Prostate Cancer and Prostatic Diseases (2000) 3, 236±240.