The Role of Cancer Stem Cell-Derived Exosomes in Cancer Progression

Li, Xueting; Li, Xinjian; Zhang, Bin; He, Baoyu

doi:10.1155/2022/9133658

Cited by 13 publications

(14 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies have investigated cancer cell-derived sEVs, which promote M2 macrophage polarization in various cancers by transferring noncoding RNAs [ 6 – 8 ]. However, whether CSC-sEVs transfer noncoding RNAs, thus inducing M2 macrophage polarization, was largely unknown in most cancers [ 9 ]. In this study, we revealed that OSCC-CSC-sEVs transferring the lncRNA UCA1 promote M2 macrophage polarization via a LAMC2-mediated PI3K/AKT axis, thereby facilitating tumor progression and immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

“…Cancer stem cells (CSCs), a small subpopulation of cancer cells, can be identified and isolated according to their expression of distinctive markers. CSC-derived-sEVs are reported to be responsible for disease progression of various cancers [9][10][11]. Interestingly, CSCs secrete sEVs associated with an immunosuppressive microenvironment and further promote M2 macrophage polarization in glioblastoma [12] and colon cancer [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2

Yao

et al. 2022

Stem Cells International

View full text Add to dashboard Cite

Cancer-derived small extracellular vesicles (sEVs) are emerging as crucial mediators of intercellular communication between cancer cells and M2-tumor-associated macrophages (M2-TAMs) via transferring lncRNAs. We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). This study hypothesize that OSCC-CSC-derived small extracellular vesicles (OSCC-CSC-sEVs) transfer a ceRNA of miR-134 and consequently promote M2 macrophage polarization by targeting LAMC2 via the PI3K/AKT pathway through in vitro and in vivo experiment methods. The results showed that sEVs derived from CD133+CD44+ OSCC cells promoted M2 polarization of macrophages by detecting several M2 macrophage markers (CD163, IL-10, Arg-1, and CD206+CD11b+). Mechanistically, we revealed that the lncRNA UCA1, by binding to miR-134, modulated the PI3K/AKT pathway in macrophages via targeting LAMC2. Importantly, OSCC-CSC-sEV transfer of UCA1, by targeting LAMC2, promoted M2 macrophage polarization and inhibited CD4+ T-cell proliferation and IFN-γ production in vitro and in vivo. Functionally, we demonstrated that M2-TAMs, by transferring exosomal UCA and consequently targeting LAMC2, enhanced cell migration and invasion of OSCC in vitro and the tumorigenicity of OSCC xenograft in nude mice. In conclusion, our results indicated that OSCC-CSC-sEV transfer of UCA1 promotes M2 macrophage polarization via a LAMC2-mediated PI3K/AKT axis, thus facilitating tumor progression and immunosuppression. Our findings provide a new understanding of OSCC-CSC molecular mechanisms and suggest a potential therapeutic strategy for OSCC through targeting CSC-sEVs and M2-TAMs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2

Yao

et al. 2022

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…The mRNA of exosomes can translate corresponding proteins, and miRNA and siRNA regulate target cells by affecting the expression of related genes 63,64 . Phagocytose exosomes can either be re‐released in target cells or degraded by the lysosomal pathway 65,66 …”

Section: Overview Of Exosomesmentioning

confidence: 99%

“…63,64 Phagocytose exosomes can either be re-released in target cells or degraded by the lysosomal pathway. 65,66 The exosomal function is closely related to their cellular origin and the protein and RNA they contain. Exosomes from different sources have different purposes at different physiological and pathological stages.…”

Section: Exosomesfunctionsmentioning

confidence: 99%

Exosomes‐mediated crosstalk between glioma and immune cells in the tumor microenvironment

2023

View full text Add to dashboard Cite

Gliomas are malignant tumors originating from the central nervous system and are characterized clinically by high morbidity, mortality, high infiltrating, and poor prognosis. 1,2 The main treatments for glioma are direct surgical resection, radiotherapy, and temozolomide chemotherapy. [3][4][5][6][7] Gliomas are classified as astrocytic, oligodendroglial, and ventricular canal tumors based on their malignancy and phenotype. [8][9][10] Diffuse gliomas can be further typed as astrocytic, oligodendroglial, or rare mixed oligodendroglial-astrocytic of World Health Organization (WHO) grade II (low grade), III (anaplastic), or IV (glioblastoma).According to the WHO histological classification, gliomas are classified as WHO grade I-IV, with glioblastoma, a WHO grade IV glioma, accounting for approximately 45% of malignant brain tumors. 11,12 The pathogenesis of glioma remains unclear, with tumorigenesis resulting from a combination of environmental and genetic factors.The tumor microenvironment (TME) consists of tumor cells and surrounding components. 13,14 It includes innate and adaptive immune cells (T lymphocytes and B lymphocytes), mesenchymal fibroblasts, and vascular and lymphatic vessel networks. Various chemokines secreted through autocrine or paracrine make up the TME. [15][16][17] Alterations in the microenvironment affect tumorigenesis and progression. The immune cell is fundamental in determining the fate of cancer and its invasiveness and metastatic capacity. 18,19 The clinical outcome of cancer patients is interrelated to the composition of immune cells that infiltrate tumors. 20,21

show abstract

“…TEXs are rich in protein, miRNA, mRNA, DNA, and lipid contents and play an essential role in the early diagnosis, development, and treatment of tumors [138][139][140]. However, because of the differences in experimental materials and research methods, the detection of single exosome contents is prone to false-positive results.…”

Section: Future Prospections and Conclusionmentioning

confidence: 99%

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

2022

View full text Add to dashboard Cite

Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and proteins and are involved in intercellular communication and function, playing an essential role in the growth and metastasis of tumors. SEVs are present in various body fluids and can be isolated and extracted from blood, urine, and cerebrospinal fluid. Under both physiological and pathological conditions, SEVs can be released by some cells, such as immune, stem, and tumor cells, in a cytosolic manner. SEVs secreted by tumor cells are called tumor-derived exosomes (TEXs) because of their origin in the corresponding parent cells. Glioma is the most common intracranial tumor, accounting for approximately half of the primary intracranial tumors, and is characterized by insidious onset, high morbidity, and high mortality rate. Complete removal of tumor tissues by surgery is difficult. Chemotherapy can improve the survival quality of patients to a certain extent; however, gliomas are prone to chemoresistance, which seriously affects the prognosis of patients. In recent years, TEXs have played a vital role in the occurrence, development, associated immune response, chemotherapy resistance, radiation therapy resistance, and metastasis of glioma. This article reviews the role of TEXs in glioma progression, drug resistance, and clinical diagnosis.

show abstract

The Role of Cancer Stem Cell-Derived Exosomes in Cancer Progression

Cited by 13 publications

References 120 publications

Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2

Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2

Exosomes‐mediated crosstalk between glioma and immune cells in the tumor microenvironment

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Contact Info

Product

Resources

About