The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved

Abstract

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Hydroxyapatite-modified micro/nanostructured titania surfaces with different crystalline phases for osteoblast regulation

“…Previous studies have confirmed that HA-modified Ti surfaces can promote cell differentiation and maturation in vitro [ [50] , [51] , [52] , 62 ], and also, HA-deposited implants were able to induce bone ingrowth at the bone-implant interface without isolation by fibrous tissue layer in vivo [ 20 , [63] , [64] , [65] , [66] ]. Although the detailed mechanism is still under exploration, the superior bioactivity and osteoconductivity of HA are related to its physicochemical properties, such as composition, morphology and geometry [ 16 , 20 , 67 ]. Moreover, the release of calcium and phosphate ions from HA into the cell-material microenvironment probably enhanced the ALP activity and extracellular matrix mineralization [ 16 , 67 ].…”

“…Although the detailed mechanism is still under exploration, the superior bioactivity and osteoconductivity of HA are related to its physicochemical properties, such as composition, morphology and geometry [ 16 , 20 , 67 ]. Moreover, the release of calcium and phosphate ions from HA into the cell-material microenvironment probably enhanced the ALP activity and extracellular matrix mineralization [ 16 , 67 ]. Ca 2+ ion plays an important role in modulating cellular functions through specific sites and receptors, including calcium-related proteins (e.g., pancreatic stone protein), extracellular matrix proteins (e.g., fibulin) and gene-associated signaling (e.g., SOX9) [ 68 ].…”

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

“…A rough surface can promote cell adhesion and differentiation; however, increasing roughness can lead to cell death. In this review the authors also reported that surface structure impacts osteogenesis by interacting with protein adsorption, cilia modulation and the immune response[136].It appears clearly that the surface properties of materials strongly influence processes involved in osteogenesis and therefore the osteointegration of orthopedic biomaterials. In a more general context, the biological response depends on a complex interaction between patient-related aspects (age, gender, metabolism, …), material properties (architecture, biodegradation, composition, porosity, …) and induced biological responses (cell adhesion and proliferation, protein adhesion, …)[137].…”

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials

“…Calcium phosphates (especially hydroxyapatite) have a high affinity for BMP (bone morphogenetic proteins), can osseointegrate, osseoconduct, and favor new bone tissue formation; therefore, they have been the main component of numerous studies, along with natural polymers (e.g., collagen, chitosan, gelatin and silk) [13,14]. The major disadvantages of these composite scaffolds are their slow biodegradability, reduced mechanical properties and potential toxicity, which restrict their clinical applications [15][16][17].…”